Results 81 to 90 of about 8,545 (211)

AXL drives regulatory cDC1 maturation to control CD8 T cell contraction during severe influenza recovery 2267518

Introduction Axl-dependent activation of XCR1+ cDC (cDC1) leads to regulatory maturation of cDC1 (mregDC1). After IAV infection, mature cDC1 dampen CD8 T cell function, however it is unknown whether this process is Axl-dependent.
Michael Schultz, Xinran Wang, Aaron Silva Sanchez, Troy Randall   +3 more
core   +1 more source

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration

Signal Transduction and Targeted Therapy
Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer ...
Fenglian He, Zhongen Wu, Chenglong Liu, Yuanyuan Zhu, Yan Zhou, Enming Tian, Rina Rosin-Arbesfeld, Dehua Yang, Ming-Wei Wang, Di Zhu   +9 more
doaj   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Porcine Reproductive and Respiratory Syndrome Virus Type 1.3 Lena Triggers Conventional Dendritic Cells 1 Activation and T Helper 1 Immune Response Without Infecting Dendritic Cells

Frontiers in Immunology, 2018
Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is an arterivirus responsible for highly contagious infection and huge economic losses in pig industry. Two species, PRRSV-1 and PRRSV-2 are distinguished, PRRSV-1 being more prevalent in Europe.
Elise Bordet, Fany Blanc, Mathieu Tiret, Elisa Crisci, Elisa Crisci, Edwige Bouguyon, Patricia Renson, Patricia Renson, Patricia Renson, Pauline Maisonnasse, Mickael Bourge, Jean-Jacques Leplat, Elisabetta Giuffra, Luc Jouneau, Isabelle Schwartz-Cornil, Olivier Bourry, Olivier Bourry, Nicolas Bertho   +17 more
doaj   +1 more source

Effects of proton therapy on the tumor immune system and clinical implications: A review

Precision Radiation Oncology, EarlyView.
Proton therapy is a novel radiotherapy technique. We review four aspects of proton therapy: application in various tumors, effects on the tumor immune system, combination with other therapies, and future challenges. By presenting these aspects in this review, we aim to inspire clinical interventions.
Rundong Liu, Mei Tao, Min Fu, Yingjia Hu, Zhen Tao, Guangyuan Hu   +5 more
wiley   +1 more source

IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connection

OncoImmunology, 2020
IL15 is a key cytokine for the activation and survival of anti-tumor effectors CD8+ T and NK cells. Recently published preclinical studies demonstrate that the therapeutic activity of IL15 requires conventional dendritic cells type 1 (cDC1). Radiotherapy
Karsten A. Pilones, Maud Charpentier, Elena Garcia-Martinez, Sandra Demaria   +3 more
doaj   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death and liver inflammation in metabolic dysfunction-associated steatohepatitis

Nature Communications
Immune dysregulation-induced inflammation serves as a driving force in the progression of metabolic dysfunction-associated steatohepatitis (MASH), while the underlying cellular and molecular mechanisms remain largely uncharted.
Yuxiang Song, Na Li, Shang Jiang, Kexin Wang, Guoyue Lv, Zhongqi Fan, Xiliang Du, Wenwen Gao, Lin Lei, Zhe Wang, Guowen Liu, Xinwei Li   +11 more
doaj   +1 more source

Stability Modelling and Analysis of an Integrated Wind‐PV‐Storage Power System: A Small‐Signal Approach Using Multi‐Coordinate System Consistency Transformation

Energy Internet, EarlyView.
ABSTRACT With growing energy demand and depletion of fossil fuels, renewable energy development is crucial for achieving dual‐carbon goals. This paper focuses on small‐signal modelling and stability analysis of a grid‐connected wind‐PV‐storage system.
Puyu Wang, Pengyu Bo, Xujie Tang, Wu Tong, Yibo Wang, Xiance Zhu, Zhiyu Cao, Xiao‐Ping Zhang   +7 more
wiley   +1 more source

NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control

, 2020
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy.
Neil C Rogers (9071588), Jan P Böttcher (9071576), Stefano Sammicheli (337566), Caetano Reis e Sousa (599615), Santiago Zelenay (9071591), Eduardo Bonavita (9071579), Probir Chakravarty (755948), Erik Sahai (829065), Hanna Blees (9071582), Mar Cabeza Cabrerizo (9071585)   +9 more
core