Results 91 to 100 of about 6,757 (189)
cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy
Circulation ResearchBACKGROUND: Atherosclerosis is characterized by immune cell accumulation in the arterial wall and adaptive CD4 + T helper 1 immunity contributes to atherosclerosis development. However, how conventional dendritic cells (DCs) orchestrate this adaptive response remains controversial ...
Miguel Galán +23 more
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F1000Research, 2017 The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses through the process of cross-presentation. The molecular mechanisms of cross-presentation remain incompletely understood because of limited biochemical analysis ...
Derek Theisen, Kenneth Murphy
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Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
Vaccination against neoantigens induced in cross-priming cDC1 in vivo
Cancer Immunology, ImmunotherapyAbstractThe conventional type 1 dendritic cells (cDC1) play a pivotal role in protective immunity against pathogens and cancer. However, their low frequency in the blood and tissues limits their use in immune therapy. We have recently described a method to vaccinate against neoantigens that are induced in tumor cells by targeted delivery of a TAP siRNA
Emily S. Clark +4 more
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Infection control in the brain and the eye
Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester +2 more
wiley +1 more source
Journal for ImmunoTherapy of CancerBackground Melanoma, the most lethal form of skin cancer, has undergone a transformative treatment shift with the advent of checkpoint blockade immunotherapy (CBI).
Saraí G De León-Rodríguez +14 more
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Cancer Science, Volume 117, Issue 8, Page 2098-2114, August 2026.Chemotherapy combined with nivolumab reshapes the gastric cancer tumor microenvironment (TME) and is accompanied by an enrichment of reduced cytotoxicity NK (RC‐NK) cells. Rather than acting as classical cytotoxic effectors, these RC‐NK cells appear to shape the TME by promoting an immunostimulatory circuit that engages adaptive immunity.
Takuya Nakatsuru +24 more
wiley +1 more source
Development and migration of cDC1 in the spleen
Precursor of dendritic cells (preDCs) develop in the bone marrow and continuously seed in tissues where preDCs further differentiate and migrate to and within secondary lymphoid organs to orchestrate adaptive immunity. Where preDCs seed the splenic red pulp, locally develop into type 1 conventional dendritic cells (cDC1s) and migrate to the white pulp ...
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Journal of Pharmaceutical AnalysisThis research investigates the regulatory role of the transcription factor PU.1 in type 1 conventional dendritic cells (cDC1) and its therapeutic potential of modulating the nuclear factor kappaB (NF-κB) cells signaling pathway in non-small cell lung ...
Tingting Wang +5 more
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Antigen presentation requirements for effective cDC1-based cancer immunotherapy
Abstract Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with in vitro
Josué E. Pineda +12 more
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