Results 91 to 100 of about 9,042 (190)

Image_2_Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses.jpeg

, 2023
Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity.
Maarten K. Nijen Twilhaar (11197329), Ilse Jongerius (246324), Admar Verschoor (251200), Katarzyna Olesek (5722949), Cees van Kooten (795358), Alsya J. Affandi (11197326), Joanna Grabowska (5722952), Mieke C. Brouwer (12755072), Gert Storm (21109), Valentine Léopold (17415510), Cornelis van ‘t Veer (694059), Yvette van Kooyk (7462034), Joke M. M. den Haan (7500083)   +12 more
core   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connection

OncoImmunology, 2020
IL15 is a key cytokine for the activation and survival of anti-tumor effectors CD8+ T and NK cells. Recently published preclinical studies demonstrate that the therapeutic activity of IL15 requires conventional dendritic cells type 1 (cDC1). Radiotherapy
Karsten A. Pilones, Maud Charpentier, Elena Garcia-Martinez, Sandra Demaria   +3 more
doaj   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, Volume 65, Issue 11, Page 1383-1397, November 2026.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

High Fat and Sugar Diet Increases Enteric cDC1 and Oral Antigen-Specific Tregs

Journal of Immunology Research
Diet-induced obesity is a growing global health concern linked to various immunological alterations. Dendritic cells (DCs) are major regulators of the balance between pro-inflammatory and tolerogenic immune responses.
K. Fischer, O. Horno, B. Raposo, I. Godinho, H. Ribeiro, H. Veiga-Fernandes, M. Martínez-López   +6 more
doaj   +1 more source

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Qiao Li, Fabian Pfersdorf, Fernando Salgado‐Polo, Martin Gustavsson   +3 more
wiley   +1 more source

AXL drives regulatory cDC1 maturation to control CD8 T cell contraction during severe influenza recovery 2267518

Introduction Axl-dependent activation of XCR1+ cDC (cDC1) leads to regulatory maturation of cDC1 (mregDC1). After IAV infection, mature cDC1 dampen CD8 T cell function, however it is unknown whether this process is Axl-dependent.
Michael Schultz, Xinran Wang, Aaron Silva Sanchez, Troy Randall   +3 more
core   +1 more source

Characterizing the Tumor Microenvironment and Its Correlation with cDC1-Related Gene Expression in Gastric Cancer

Journal of Immunology Research
Background and Aim. Gastric cancer (GC) remains a significant global health challenge. The role of conventional type 1 dendritic cells (cDC1s) in the tumor microenvironment and their association with cancer prognosis is gaining attention. This study aims
Song-Hee Han, Mi Ha Ju
doaj   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, Volume 104, Issue 10, Page 1019-1034, November‐December 2026.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

Type I-conventional dendritic cells support the progression of multiple myeloma in the bone marrow

Frontiers in Immunology
PurposeType I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remains unclear whether cDC1 has a protective or pathogenic role in
Sayaka Suzuki, Sayaka Suzuki, Kazuma Komiya, Shogo Tsuda, Miya Yoshino, Tsuneyasu Kaisho, P. Leif Bergsagel, Koji Kawamura, Tetsuya Fukuda, Tetsuya Fukuda, Koji Tokoyoda   +10 more
doaj   +1 more source