Results 101 to 110 of about 9,042 (190)

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Siglec Expression Patterns in Food Allergy Reveal Altered Intensity but Not Frequency

Clinical &Experimental Allergy, EarlyView.
J. S. H. Schaapherder, A. M. Ehlers, E. F. Knol, A. C. Knulst, G. J. P. H. Boons, K. C. M. Verhoeckx   +5 more
wiley   +1 more source

Enhancing tumor immunity via in vivo cDC1 reprogramming

Trends in Immunology
A recent study by Ascic et al. demonstrates that in situ reprogramming of tumor cells into conventional dendritic cell (cDC)-like cells using viral-PIB transcription factors creates an immunogenic tumor microenvironment with T cell recruitment and activation.
Yoojung, Kwon, Kyunghee, Choi
openaire   +2 more sources

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

Nature Communications
Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings.
Lucía López, Luciano Gastón Morosi, Federica La Terza, Pierre Bourdely, Giuseppe Rospo, Roberto Amadio, Giulia Maria Piperno, Valentina Russo, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Luigia Pace, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti   +20 more
doaj   +1 more source

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis

Frontiers in Immunology
IntroductionMultiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), in which various immune cells contribute to disease progression, yet the role of dendritic cells (DCs) remains incompletely understood ...
Xingyu Rong, Hai Wang, Shintaro Muraoka, Takuya Uehata, Masanori Yoshinaga, Tsuneyasu Kaisho, Osamu Takeuchi   +6 more
doaj   +1 more source

cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy

Circulation Research
BACKGROUND: Atherosclerosis is characterized by immune cell accumulation in the arterial wall and adaptive CD4 + T helper 1 immunity contributes to atherosclerosis development. However, how conventional dendritic cells (DCs) orchestrate this adaptive response remains controversial ...
Miguel Galán, Laura Fernández-Méndez, Vanessa Núñez, Marcos Femenía-Muiña, Pau Figuera-Belmonte, Elena Moya-Ruiz, Sarai Martínez-Cano, Elena Hernández-García, Manuel Rodrigo-Tapias, Ana Rodríguez-Ronchel, Carlos Relaño-Rupérez, Stefanie K. Wculek, Alberto Benguria, Ana Dopazo, Sandrine Henri, Suin Jo, Tian-Tian Liu, Bernard Malissen, Kenneth M. Murphy, Almudena R. Ramiro, Susana Carregal-Romero, Jesús Ruiz-Cabello, Iñaki Robles-Vera, David Sancho   +23 more
openaire   +4 more sources

Cdc1 and the Vacuole Coordinately Regulate Mn2+ Homeostasis in the Yeast Saccharomyces cerevisiae

Genetics, 1998
Abstract The yeast CDC1 gene encodes an essential protein that has been implicated in the regulation of cytosolic [Mn2+]. To identify factors that impinge upon Cdc1 or the Cdc1-dependent process, we isolated secondsite suppressors of the conditional cdc1-1(Ts) growth defect.
M, Paidhungat, S, Garrett
openaire   +2 more sources

Development and migration of cDC1 in the spleen

Precursor of dendritic cells (preDCs) develop in the bone marrow and continuously seed in tissues where preDCs further differentiate and migrate to and within secondary lymphoid organs to orchestrate adaptive immunity. Where preDCs seed the splenic red pulp, locally develop into type 1 conventional dendritic cells (cDC1s) and migrate to the white pulp ...
openaire   +2 more sources

TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response

Journal for ImmunoTherapy of Cancer
Background Melanoma, the most lethal form of skin cancer, has undergone a transformative treatment shift with the advent of checkpoint blockade immunotherapy (CBI).
Saraí G De León-Rodríguez, Cristina Aguilar-Flores, Julián A Gajón, Ángel Juárez-Flores, Alejandra Mantilla, Raquel Gerson-Cwilich, José Fabián Martínez-Herrera, Diana Alejandra Villegas-Osorno, Claudia T Gutiérrez-Quiroz, Sergio Buenaventura-Cisneros, Mario Alberto Sánchez-Prieto, Edmundo Castelán-Maldonado, Samuel Rivera Rivera, Ezequiel M Fuentes-Pananá, Laura C Bonifaz   +14 more
doaj   +1 more source

Figure S1 from Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8⁺ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

, 2020
Gating strategies of migratory cDC, APC, cDC1 and ...
Sinead M. Lougheed (15007587), Gemma G. Kenter (9857057), Maaike C.G. Bleeker (6563789), A. Marijne Heeren (15022752), Ekaterina S. Jordanova (9857063), Anita G.M. Stam (15022761), Tanja D. de Gruijl (8805821), Awa A. Gassama (15022755), Noëlle Pocorni (15022758), Constantijne H. Mom (15022767), Jossie Rotman (14951019), Henry J.M.A.A Zijlmans (15022764)   +11 more
core   +1 more source