Results 101 to 110 of about 6,757 (189)

IRF8 maintains mononuclear phagocyte and neutrophil function in acute kidney injury

Heliyon
Immune cells are key players in acute tissue injury and inflammation, including acute kidney injury (AKI). Their development, differentiation, activation status, and functions are mediated by a variety of transcription factors, such as interferon ...
Na Li, Stefanie Steiger, Ming Zhong, Meihua Lu, Yan Lei, Chun Tang, Jiasi Chen, Yao Guo, Jinhong Li, Dengyang Zhang, Jingyi Li, Enyi Zhu, Zhihua Zheng, Julia Lichtnekert, Yun Chen, Xiaohua Wang   +15 more
doaj   +1 more source

cDC1 cross-priming [PDF]

Nature Immunology, 2018
openaire   +2 more sources

CD103+ cDC1 Dendritic Cell Vaccine Therapy for Osteosarcoma Lung Metastases

Cancers
Background: We generated a CD103+DC vaccine using K7M3 OS cell lysates (cDCV) and investigated its ability to induce regression of primary tumors, established lung metastases, and a systemic immune response. Methods: A bilateral tumor model was used to assess cDCV therapy efficacy and systemic immunity induction.
Yuanzheng Yang, Yifan Zhou, Jian Wang, You Zhou, Stephanie S. Watowich, Eugenie S. Kleinerman   +5 more
openaire   +2 more sources

Elimination of cDC1 cells by regulatory T cells jeopardizes cancer immunotherapy

OncoImmunology
Recent findings revealed that neoantigen-specific cytotoxic type 1 regulatory T (TR1) CD4 T cells can subvert cancer immunotherapy by killing type 1 conventional dendritic cells (cDC1s) that present tumor antigens bound to MHC class II. This underlines the importance of cDC1s for eliciting anticancer immunity but poses a novel clinical challenge.
Liu, Peng, Zhao, Liwei, Kroemer, Guido, Kepp, Oliver   +3 more
openaire   +3 more sources

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source

Gpr31 and Gpr146 distinguish cDC1 and cDC2.

We measured total transcription in dendritic cell subsets: the cDC type 1 or cDC1, and in the cDC2. We report here discovery of G-protein coupled receptors (Gpr) that fully distinguished BDCA1+ and BDCA3+ DC populations. CDC1 specifically expressed CD31, while cDC2 specifically expressed CD146.
openaire   +2 more sources

Granulocyte-macrophage colony-stimulating factor may contribute to spondyloarthritis development in HLA-B27 transgenic rat by affecting conventional dendritic cells function

Arthritis Research & Therapy
Background Spondyloarthritis (SpA) is a chronic inflammatory disorder with axial and peripheral manifestations. A strong association between HLA-B27 and SpA has been known for more than 50 years.
Amel Ait Ali Said, Chiara Rizzo, Hendrick Mambu Mambueni, Félicie Costantino, Maxime Breban, Simon Glatigny   +5 more
doaj   +1 more source

Conventional type-1 DC density is associated with checkpoint inhibitor response across multiple types of cancer. [PDF]

J Clin Invest
Lopez-Janeiro A, González-Gomariz J, Issa F, Hester J, Porciuncula A, Teijeira A, Luri-Rey C, Ruiz-Guillamon D, Perez-Gracia JL, Perez-Ruiz E, Barragan I, Martín-Algarra S, Sanmamed MF, Ortego I, Rodriguez-Ruiz ME, Alexandru R, Rodriguez I, Arrieta-Aranzueque S, Rimm D, Aung T, Schalper KA, de Andrea CE, Melero I.   +22 more
europepmc   +1 more source

CD4 ^<b>+</b> cell depletion accelerates dendritic cell migration and enhances resident dendritic cell proliferation in tumor-draining lymph nodes. [PDF]

Oncoimmunology
Moriya T, Hashimoto M, Ueda M, Aoyagi T, Kawaguchi A, Takahashi K, Tsukasa K, Doi K, Hemmi H, Kaisho T, Ueha S, Matsushima K, Kusumoto Y, Chtanova T, Tomura M.   +14 more
europepmc   +1 more source

Myeloid dendritic cell subsets characterise muscle in patients with inclusion body myositis and correlate with the IFN-γ pathway and effector T cell markers. [PDF]

Ann Rheum Dis
Kirou RA, Pinal-Fernandez I, Casal-Dominguez M, Pak K, Ikenaga C, Nelke C, Wischnewski S, Preusse C, Del Orso S, Naz F, Islam S, Gutierrez-Cruz G, Lloyd TE, Schirmer L, Ruck T, Stenzel W, Selva-O'Callaghan A, Milisenda JC, Mammen AL.   +18 more
europepmc   +1 more source