Results 111 to 120 of about 9,042 (190)

PU.1 regulation of type 1 dendritic cell function via NF-κB pathway in inhibition of non-small cell lung cancer progression

Journal of Pharmaceutical Analysis
This research investigates the regulatory role of the transcription factor PU.1 in type 1 conventional dendritic cells (cDC1) and its therapeutic potential of modulating the nuclear factor kappaB (NF-κB) cells signaling pathway in non-small cell lung ...
Tingting Wang, Yishuo Li, Qiongyu Duan, Chunlei Wang, Yixian Wang, Tianyu Hu   +5 more
doaj   +1 more source

Self-antigen disrupts cDC1 mediated antitumor responses

ABSTRACT Conventional dendritic cells navigate complex tissues and sample peripheral antigens, balancing immune suppression and activation to achieve tissue homeostasis. However, it remains unclear how an individual dendritic cells reconciles co-incident signals from immunological opposing antigens within the tissue ...
Victoria P Schuster, Kasidy Brown, Valentina Laverde, Naomi Berkowitz, Alyssa M Granados, Naoki Oshimori, John M Leech, Antonin Weckel, Tiffany C Scharschmidt, Megan K Ruhland   +9 more
openaire   +2 more sources

cDC1 cross-priming [PDF]

Nature Immunology, 2018
openaire   +2 more sources

Regulatory maturation of cDC1 accelerates effector CD8 T cell contraction after severe influenza A virus infection 2267170

Introduction XCR1+ dendritic cells (cDC1) initiate CD8 T cell responses against Influenza A virus (IAV) infection. In the resolution phase, sustained cytokine production by CD8 T cells prolong lung damage, however, whether cDC1 ...
Michael Schultz, Xinran Wang, Aaron Silva-Sanchez, Emon Hossain, Troy Randall   +4 more
core   +1 more source

IRF8 maintains mononuclear phagocyte and neutrophil function in acute kidney injury

Heliyon
Immune cells are key players in acute tissue injury and inflammation, including acute kidney injury (AKI). Their development, differentiation, activation status, and functions are mediated by a variety of transcription factors, such as interferon ...
Na Li, Stefanie Steiger, Ming Zhong, Meihua Lu, Yan Lei, Chun Tang, Jiasi Chen, Yao Guo, Jinhong Li, Dengyang Zhang, Jingyi Li, Enyi Zhu, Zhihua Zheng, Julia Lichtnekert, Yun Chen, Xiaohua Wang   +15 more
doaj   +1 more source

CD103+ cDC1 Dendritic Cell Vaccine Therapy for Osteosarcoma Lung Metastases

Cancers
Background: We generated a CD103+DC vaccine using K7M3 OS cell lysates (cDCV) and investigated its ability to induce regression of primary tumors, established lung metastases, and a systemic immune response. Methods: A bilateral tumor model was used to assess cDCV therapy efficacy and systemic immunity induction.
Yuanzheng Yang, Yifan Zhou, Jian Wang, You Zhou, Stephanie S. Watowich, Eugenie S. Kleinerman   +5 more
openaire   +2 more sources

Gpr31 and Gpr146 distinguish cDC1 and cDC2.

We measured total transcription in dendritic cell subsets: the cDC type 1 or cDC1, and in the cDC2. We report here discovery of G-protein coupled receptors (Gpr) that fully distinguished BDCA1+ and BDCA3+ DC populations. CDC1 specifically expressed CD31, while cDC2 specifically expressed CD146.
openaire   +2 more sources

46 Anti-tumour immune responses in melanoma brain metastases require cDC1 population and the extracranial tumour

Introduction Brain metastases (BrM) are associated with poor prognosis, partially due to the specialized immune-microenvironment in the brain. Our previous study demonstrated that intracranial tumours alone are poorly immunogenic, but
Sukhveer Kaur Mann, Karen Hogg, Alca Revalova, Mihaela Lorger, Dario Guglietta, Jennifer Williams, William Brackenbury, Andrew MacDonald, Tsuneyasu Kaisho, Fiona James, Christopher Fife   +10 more
core   +1 more source

Elimination of cDC1 cells by regulatory T cells jeopardizes cancer immunotherapy

OncoImmunology
Recent findings revealed that neoantigen-specific cytotoxic type 1 regulatory T (TR1) CD4 T cells can subvert cancer immunotherapy by killing type 1 conventional dendritic cells (cDC1s) that present tumor antigens bound to MHC class II. This underlines the importance of cDC1s for eliciting anticancer immunity but poses a novel clinical challenge.
Liu, Peng, Zhao, Liwei, Kroemer, Guido, Kepp, Oliver   +3 more
openaire   +3 more sources

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source