Results 121 to 130 of about 8,545 (211)
Journal of Pharmaceutical AnalysisThis research investigates the regulatory role of the transcription factor PU.1 in type 1 conventional dendritic cells (cDC1) and its therapeutic potential of modulating the nuclear factor kappaB (NF-κB) cells signaling pathway in non-small cell lung ...
Tingting Wang +5 more
doaj +1 more source
Plasma Cell Selection and Migration in the Establishment of Long‐Lived Antibody Responses
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT As B cells are activated and differentiate into plasma cells, they execute migration programs that allow them to traffic within secondary lymphoid tissues and reach the bone marrow, where they can mature as long‐lived plasma cells. Recent studies have revealed mechanisms underlying not only affinity‐driven but also isotype‐driven plasma cell ...
Wataru Ise +2 more
wiley +1 more source
Elimination of cDC1 cells by regulatory T cells jeopardizes cancer immunotherapy
OncoImmunologyRecent findings revealed that neoantigen-specific cytotoxic type 1 regulatory T (TR1) CD4 T cells can subvert cancer immunotherapy by killing type 1 conventional dendritic cells (cDC1s) that present tumor antigens bound to MHC class II. This underlines the importance of cDC1s for eliciting anticancer immunity but poses a novel clinical challenge.
Liu, Peng +3 more
openaire +3 more sources
, 2018 The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance in dendritic cells (DCs) is unexplored until now. For the first time we report here that Zeb1 controls immunogenic
Sunil K. Raghav (3259440) +7 more
core +1 more source
CD103+ cDC1 Dendritic Cell Vaccine Therapy for Osteosarcoma Lung Metastases
CancersBackground: We generated a CD103+DC vaccine using K7M3 OS cell lysates (cDCV) and investigated its ability to induce regression of primary tumors, established lung metastases, and a systemic immune response. Methods: A bilateral tumor model was used to assess cDCV therapy efficacy and systemic immunity induction.
Yuanzheng Yang +5 more
openaire +2 more sources
IRF8 maintains mononuclear phagocyte and neutrophil function in acute kidney injury
HeliyonImmune cells are key players in acute tissue injury and inflammation, including acute kidney injury (AKI). Their development, differentiation, activation status, and functions are mediated by a variety of transcription factors, such as interferon ...
Na Li +15 more
doaj +1 more source
, 2018 The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance in dendritic cells (DCs) is unexplored until now. For the first time we report here that Zeb1 controls immunogenic
Sunil K. Raghav (3259440) +7 more
core +1 more source
Gpr31 and Gpr146 distinguish cDC1 and cDC2.
We measured total transcription in dendritic cell subsets: the cDC type 1 or cDC1, and in the cDC2. We report here discovery of G-protein coupled receptors (Gpr) that fully distinguished BDCA1+ and BDCA3+ DC populations. CDC1 specifically expressed CD31, while cDC2 specifically expressed CD146.
openaire +2 more sources
, 2018 The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance in dendritic cells (DCs) is unexplored until now. For the first time we report here that Zeb1 controls immunogenic
Sunil K. Raghav (3259440) +7 more
core +1 more source