Results 61 to 70 of about 9,042 (190)

Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Frontiers in Immunology, 2018
Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8+ T cells, which is crucial for orchestrating efficient immune responses against viruses or tumors.
Raphaël Mattiuz, Christian Wohn, Sonia Ghilas, Marc Ambrosini, Yannick O. Alexandre, Cindy Sanchez, Anissa Fries, Thien-Phong Vu Manh, Bernard Malissen, Bernard Malissen, Marc Dalod, Karine Crozat   +11 more
doaj   +1 more source

Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung

Allergology International, 2021
Background: Follicular helper T (Tfh) cells represent a unique subset of helper CD4+ T cells in lymphoid follicles. Recently, Tfh cells were shown to play an important role in asthma through B cell differentiation.
Shogo Sakurai, Kazuki Furuhashi, Ryo Horiguchi, Fumiya Nihashi, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda   +12 more
doaj   +1 more source

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source

18F‐FGln PET/CT Imaging of Glutamine Uptake Has Potential for Predicting Immunotherapy Response in Hepatocellular Carcinoma

Advanced Science, EarlyView.
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu, Jindian Li, Xiaoyu Pan, Xiaoping Xu, Xuan Huang, Simin He, Jianping Zhang, Fei Liu, Shaoli Song   +8 more
wiley   +1 more source

Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity [PDF]

Frontiers in Immunology, 2019
Dendritic cells (DCs) efficiently process and present antigens to T cells, and by integrating environmental signals, link innate and adaptive immunity. DCs also control the balance between tolerance and immunity, and are required for T-cell mediated anti-tumor immunity.
Rajkumar Noubade, Sonia Majri-Morrison, Kristin V. Tarbell   +2 more
openaire   +3 more sources

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

cDC1 Subtype‐Specific In Vivo Targeting of Liposomes

Advanced Science
ABSTRACT Targeted modulation of immune cells holds great promise for improving therapeutic efficacy and minimizing systemic side effects; however, current strategies with nanocarriers often rely on untargeted or labor‐intensive approaches. To bridge this gap, combining clinically approved nanocarrier systems like liposomes with highly
Maximilian Schaaf, Michael Fichter, Lin Jian, Felicia Schön, Carina Jung, Paul Schneider, Kai Speth, Ana Mateos‐Maroto, Volker Mailänder, Kaloian Koynov, Svenja Morsbach, Katharina Landfester   +11 more
openaire   +3 more sources

Image_1_Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses.jpeg

, 2023
Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity.
Maarten K. Nijen Twilhaar (11197329), Ilse Jongerius (246324), Admar Verschoor (251200), Katarzyna Olesek (5722949), Cees van Kooten (795358), Alsya J. Affandi (11197326), Joanna Grabowska (5722952), Mieke C. Brouwer (12755072), Gert Storm (21109), Valentine Léopold (17415510), Cornelis van ‘t Veer (694059), Yvette van Kooyk (7462034), Joke M. M. den Haan (7500083)   +12 more
core   +1 more source

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication [PDF]

, 2022
Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different ...
Durai, Vivek, et al.,, Colonna, Marco, Bagadia, Prachi, Gargaro, Marco, Murphy, Kenneth M, Murphy, Theresa L, Theisen, Derek J, Briseño, Carlos G, Kim, Sunkyung, Murphy, Theresa L., Chenling A. Xu, Nicola Giacchè, Pellicciari, Roberto, zu Hörste, Gerd Meyer, Boon, Louis, Murphy, Kenneth M., Scalisi, Giulia, Giulia Mencarelli, Ricciuti, Doriana, Orabona, Ciriana, Derek J. Theisen, Calvitti, Mario, Louis Boon, Roberto Pellicciari, Eleonora Padiglioni, Manni, Giorgia, Bessede, Alban, Marco Colonna, Mencarelli, Giulia, Colliva, Carolina, Puccetti, Paolo, Ciriana Orabona, Briseño, Carlos G., Giacchè, Nicola, Fallarino, Francesca, Giorgia Manni, Prachi Bagadia, Carlos G. Briseño, Della Fazia, Maria A., Theresa L. Murphy, Marco Gargaro, Carolina Colliva, Giuseppe Servillo, Maria A. Della Fazia, Xu, Chenling A., Teresa Zelante, Dietmar Fuchs, Kenneth M. Murphy, Marilena Castelli, Alban Bessede, Castelli, Marilena, Giulia Scalisi, Servillo, Giuseppe, Francesca Fallarino, Paolo Puccetti, Padiglioni, Eleonora, Vivek Durai, Fuchs, Dietmar, Mario Calvitti, Zelante, Teresa, Gerd Meyer zu Hörste, Doriana Ricciuti, Sunkyung Kim, Theisen, Derek J.   +64 more
core   +1 more source