Results 31 to 40 of about 8,545 (211)

Priority lane to cDC1 open for IRF8+ progenitors [PDF]

Blood, 2019
In this issue of Blood , Kurotaki et al demonstrate that IRF8 expression delineates a subset of lymphoid-primed multipotent progenitors (LMPPs) biased toward the generation of conventional type 1 dendritic cells (cDC1s) by epigenetically priming the precursors for the expression of dendritic cell (DC) lineage genes ...
Martin Guilliams, Charlotte L. Scott
openaire   +2 more sources

cDC1 are required for the initiation of collagen-induced arthritis

Journal of Translational Autoimmunity, 2020
Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains unknown. Several cell types have been described to potentiate/aggravate the arthritic process however the initiating event in synovial inflammation is still elusive. Dendritic cells (DCs) are essential for the initiation of primary immune responses and thus we hypothesized ...
Ramos, Maria Ines, Garcia, Samuel, Helder, Boy, Aarrass, Saida, Reedquist, Kris A., Jacobsen, Sten E., Tak, Paul, Lebre, Maria Cristina   +7 more
openaire   +4 more sources

Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors

Bio-Protocol, 2020
Ectopic expression of transcription factor combinations has been recently demonstrated to reprogram differentiated somatic cells towards the dendritic cell (DC) lineage without reversion to a multipotent state.
Fábio Rosa, Cristiana Pires, Olga Zimmermannova, Carlos- Pereira   +3 more
doaj   +1 more source

Data from cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host cDC1

, 2023
<div>Abstract<p>As a cell-based cancer vaccine, dendritic cells (DC), derived from peripheral blood monocytes or bone marrow (BM) treated with GM-CSF (GMDC), were initially thought to induce antitumor immunity by presenting tumor antigens directly to host T cells.
Kenneth M. Murphy, Theresa L. Murphy, Robert D. Schreiber, Tian-Tian Liu, Jing Chen, Sunkyung Kim, Xiao Huang, Renee Wu, Feiya Ou, Ray A. Ohara, Stephen T. Ferris   +10 more
openaire   +1 more source

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

Frontiers in Immunology, 2022
Dendritic cell (DC) fine-tunes inflammatory versus tolerogenic responses to protect from immune-pathology. However, the role of co-regulators in maintaining this balance is unexplored.
Atimukta Jha, Atimukta Jha, Abdul Ahad, Abdul Ahad, Gyan Prakash Mishra, Gyan Prakash Mishra, Kaushik Sen, Shuchi Smita, Shuchi Smita, Aliva Prity Minz, Viplov Kumar Biswas, Viplov Kumar Biswas, Archana Tripathy, Shantibhushan Senapati, Shantibhushan Senapati, Bhawna Gupta, Hans Acha-Orbea, Sunil Kumar Raghav, Sunil Kumar Raghav   +18 more
doaj   +1 more source

An adjuvant-containing cDC1-targeted recombinant fusion vaccine conveys strong protection against murine melanoma growth and metastasis

OncoImmunology, 2022
Type 1 conventional dendritic cells (cDC1) efficiently cross-present antigens that prime cytotoxic CD8+ T cells. cDC1 therefore constitute conceivable targets in cancer vaccine development.
Mohammad Arabpour, Sanchari Paul, Hanna Grauers Wiktorin, Mustafa Kaya, Roberta Kiffin, Nils Lycke, Kristoffer Hellstrand, Anna Martner   +7 more
doaj   +1 more source

Are Conventional Type 1 Dendritic Cells Critical for Protective Antitumor Immunity and How?

Frontiers in Immunology, 2019
Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate their expansion, functional polarization and effector activity in non-lymphoid tissues or in their draining lymph nodes.
Jean-Charles Cancel, Karine Crozat, Marc Dalod, Raphaël Mattiuz   +3 more
doaj   +1 more source

Human cDC1s display constitutive activation of the UPR sensor IRE1

European Journal of Immunology, 2022
AbstractThe intracellular mechanisms safeguarding DC function are of biomedical interest in several immune‐related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation of the unfolded protein response (UPR) sensor IRE1.
Paulina García‐González, Dominique Fernández, Diane Gutiérrez, Mauro Parra‐Cordero, Fabiola Osorio   +4 more
openaire   +3 more sources

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Cross‐dressed cDC1s instruct T cells in allorecognition [PDF]

Immunology & Cell Biology, 2020
A new model has been proposed by Li et al. for the role of DC subsets in the semidirect pathway of allorecognition.
openaire   +2 more sources