Results 11 to 20 of about 9,042 (190)

Conventional type 1 dendritic cells (cDC1) in cancer immunity

Biology Direct, 2023
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses.
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp   +3 more
doaj   +5 more sources

γδ T Cell-Mediated Activation of cDC1 Orchestrates CD4+ Th1 Cell Priming in Malaria [PDF]

Frontiers in Immunology
γδ T cells facilitate the CD4+ T helper 1 (Th1) cell response against Plasmodium infection by activating conventional dendritic cells (cDCs), although the underlying mechanism remains elusive.
Katsuyuki Yui, Shin-Ichi Inoue, Yarob Ibraheem   +2 more
exaly   +8 more sources

Supplementary Figure from cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host cDC1

, 2023
Supplementary Figure from cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host ...
Kenneth M. Murphy, Theresa L. Murphy, Robert D. Schreiber, Tian-Tian Liu, Jing Chen, Sunkyung Kim, Xiao Huang, Renee Wu, Feiya Ou, Ray A. Ohara, Stephen T. Ferris   +10 more
openaire   +2 more sources

IL-6 selectively suppresses cDC1 specification via C/EBPβ [PDF]

Journal of Experimental Medicine, 2023
Cytokines produced in association with tumors can impair antitumor immune responses by reducing the abundance of type 1 conventional dendritic cells (cDC1), but the mechanism remains unclear. Here, we show that tumor-derived IL-6 generally reduces cDC development but selectively impairs cDC1 development in both murine and human systems through the ...
Sunkyung Kim, Jing Chen, Suin Jo, Feiya Ou, Stephen T. Ferris, Tian-Tian Liu, Ray A. Ohara, David A. Anderson, Renee Wu, Michael Y. Chen, William E. Gillanders, William E. Gillanders, Theresa L. Murphy, Kenneth M. Murphy   +13 more
openaire   +4 more sources

An adjuvant-containing cDC1-targeted recombinant fusion vaccine conveys strong protection against murine melanoma growth and metastasis [PDF]

OncoImmunology, 2022
Type 1 conventional dendritic cells (cDC1) efficiently cross-present antigens that prime cytotoxic CD8+ T cells. cDC1 therefore constitute conceivable targets in cancer vaccine development.
Mohammad Arabpour, Sanchari Paul, Hanna Grauers Wiktorin, Mustafa Kaya, Roberta Kiffin, Nils Lycke, Kristoffer Hellstrand, Anna Martner   +7 more
doaj   +3 more sources

CD4 + helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment [PDF]

Nature Communications, 2023
The presence of classical type 1 dendritic cells (cDC1) positively influences prognosis in cancer, but their intricate networking with the various T cell types found in the tumour microenvironment is not fully appreciated. Here the authors show that cDC1
Xin Lei, Indu Khatri, Tom de Wit, Iris de Rink, Marja Nieuwland, Ron Kerkhoven, Hans van Eenennaam, Chong Sun, Abhishek D. Garg, Jannie Borst, Yanling Xiao   +10 more
doaj   +2 more sources

Antigen presentation requirements for effective cDC1-based cancer immunotherapy. [PDF]

J Immunol
Abstract Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with in vitro
Pineda JE, Minowa T, Shen L, Zhou Y, Dyevoich A, Patel B, Schneider SM, Keshari S, Saha A, Riba MN, Wang J, Watowich SS, Gubin MM.   +12 more
europepmc   +5 more sources

Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment

Trends in Immunology, 2022
Interferon regulatory factor 8 (IRF8) has long been associated with conventional dendritic cell type I (cDC1) development. In a recent study, Lança et al. demonstrate that IRF8 is also crucial in cells already committed to the cDC1 lineage. Here, deletion of IRF8 from the XCR1-expressing pre-cDC1 stage onward leads to a loss of commitment and ...
Waller, Kathryn, Scott, Charlotte L.
openaire   +3 more sources

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity

Nature Communications
Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlighting the need ...
Louise Gorline, Fillipe Luiz Rosa do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vetillard, Aboubacar Sidiki K Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, Zeina Abou Nader, Judith Weber, Hannah Theobald, Matthieu Collin, Joseph Calmette, Giorgio Anselmi, Flavia Fico, Florent Ginhoux, Laleh Majlessi, Emmanuel L. Gautier, Loredana Saveanu, Julie Helft, Marc Dalod, Mathilde Dusseaux, James P. Di Santo, Stéphanie Hugues, Pierre Guermonprez   +31 more
doaj   +2 more sources

Identification of heterogeneous subtypes of human dendritic cells from the lymph nodes of patients with gastric cancer [PDF]

Frontiers in Immunology
ObjectiveThe subtypes of heterogeneous conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) in lymph nodes (LN) cannot be distinguished because they share similar surface markers.
Song-Hee Han, In-Jeong Lee, Hue Vy An Tran, Mi Ha Joo, Kwan Woo Kim, JungMo Kim, Seung Ho Kim, Hyun Goo Woo, Hyun Goo Woo, Min Chan Kim, Jong-Young Kwak   +10 more
doaj   +2 more sources