Results 11 to 20 of about 6,757 (189)

Conventional type 1 dendritic cells (cDC1) in cancer immunity

Biology Direct, 2023
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses.
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp   +3 more
doaj   +4 more sources

cDC1 dysregulation in cancer: An opportunity for intervention [PDF]

Journal of Experimental Medicine, 2020
Conventional dendritic cells driven by the transcription factor Batf3 (cDC1 cells) are critical for the activation and maintenance of tumor-specific CD8+ T cells. In this issue of JEM, Lin et al. (https://doi.org/10.1084/jem.20190673) demonstrate systemic dysfunction of cDC1 cells in pancreatic cancer, which offers potential treatment strategies to ...
Thomas F. Gajewski, Kyle R. Cron
openaire   +2 more sources

Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T‐cell protective responses to breast cancer

Clinical & Translational Immunology, 2021
Objectives To better understand how immune responses may be harnessed against breast cancer, we investigated which immune cell types and signalling pathways are required for spontaneous control of a mouse model of mammary adenocarcinoma.
Raphaël Mattiuz, Carine Brousse, Marc Ambrosini, Jean‐Charles Cancel, Gilles Bessou, Julie Mussard, Amélien Sanlaville, Christophe Caux, Nathalie Bendriss‐Vermare, Jenny Valladeau‐Guilemond, Marc Dalod, Karine Crozat   +11 more
doaj   +1 more source

The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells

Nature Communications, 2023
Type 1 conventional dendritic cells (cDC1) are the most efficient cross-presenting cells that induce protective cytotoxic T cell response. However, the regulation of their homeostasis and function is incompletely understood.
Yan Wang, Quan Zhang, Tingting He, Yechen Wang, Tianqi Lu, Zengge Wang, Yiyi Wang, Shen Lin, Kang Yang, Xinming Wang, Jun Xie, Ying Zhou, Yazhen Hong, Wen-Hsien Liu, Kairui Mao, Shih-Chin Cheng, Xin Chen, Qiyuan Li, Nengming Xiao   +18 more
doaj   +1 more source

STAT3 signaling modulates the immune response induced after antigen targeting to conventional type 1 dendritic cells through the DEC205 receptor

Frontiers in Immunology, 2022
Conventional dendritic cells (cDC) are a group of antigen-presenting cells specialized in priming T cell responses. In mice, splenic cDC are divided into conventional type 1 DC (cDC1) and conventional type 2 (cDC2).
Fernando Bandeira Sulczewski, Larissa Alves Martino, Davi Salles, Márcio Massao Yamamoto, Daniela Santoro Rosa, Daniela Santoro Rosa, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin   +7 more
doaj   +1 more source

Priority lane to cDC1 open for IRF8+ progenitors [PDF]

Blood, 2019
In this issue of Blood , Kurotaki et al demonstrate that IRF8 expression delineates a subset of lymphoid-primed multipotent progenitors (LMPPs) biased toward the generation of conventional type 1 dendritic cells (cDC1s) by epigenetically priming the precursors for the expression of dendritic cell (DC) lineage genes ...
Martin Guilliams, Charlotte L. Scott
openaire   +2 more sources

Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors

Bio-Protocol, 2020
Ectopic expression of transcription factor combinations has been recently demonstrated to reprogram differentiated somatic cells towards the dendritic cell (DC) lineage without reversion to a multipotent state.
Fábio Rosa, Cristiana Pires, Olga Zimmermannova, Carlos- Pereira   +3 more
doaj   +1 more source

cDC1 are required for the initiation of collagen-induced arthritis

Journal of Translational Autoimmunity, 2020
Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains unknown. Several cell types have been described to potentiate/aggravate the arthritic process however the initiating event in synovial inflammation is still elusive. Dendritic cells (DCs) are essential for the initiation of primary immune responses and thus we hypothesized ...
Ramos, Maria Ines, Garcia, Samuel, Helder, Boy, Aarrass, Saida, Reedquist, Kris A., Jacobsen, Sten E., Tak, Paul, Lebre, Maria Cristina   +7 more
openaire   +4 more sources

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

Frontiers in Immunology, 2022
Dendritic cell (DC) fine-tunes inflammatory versus tolerogenic responses to protect from immune-pathology. However, the role of co-regulators in maintaining this balance is unexplored.
Atimukta Jha, Atimukta Jha, Abdul Ahad, Abdul Ahad, Gyan Prakash Mishra, Gyan Prakash Mishra, Kaushik Sen, Shuchi Smita, Shuchi Smita, Aliva Prity Minz, Viplov Kumar Biswas, Viplov Kumar Biswas, Archana Tripathy, Shantibhushan Senapati, Shantibhushan Senapati, Bhawna Gupta, Hans Acha-Orbea, Sunil Kumar Raghav, Sunil Kumar Raghav   +18 more
doaj   +1 more source

Data from cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host cDC1

, 2023
<div>Abstract<p>As a cell-based cancer vaccine, dendritic cells (DC), derived from peripheral blood monocytes or bone marrow (BM) treated with GM-CSF (GMDC), were initially thought to induce antitumor immunity by presenting tumor antigens directly to host T cells.
Kenneth M. Murphy, Theresa L. Murphy, Robert D. Schreiber, Tian-Tian Liu, Jing Chen, Sunkyung Kim, Xiao Huang, Renee Wu, Feiya Ou, Ray A. Ohara, Stephen T. Ferris   +10 more
openaire   +1 more source