Results 71 to 80 of about 4,483,430 (258)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases

Haematologica, 2009
Background Increased circulating endothelial microparticles, resulting from vascular endothelium dysfunction, and plasmacytoid dendritic cell activation are both encountered in common inflammatory disorders.
Fanny Angelot, Estelle Seillès, Sabeha Biichlé, Yael Berda, Béatrice Gaugler, Joel Plumas, Laurence Chaperot, Françoise Dignat-George, Pierre Tiberghien, Philippe Saas, Francine Garnache-Ottou   +10 more
doaj   +1 more source

Dendritic Cell‐Based Immunotherapy: The Importance of Dendritic Cell Migration

Journal of Immunology Research
Dendritic cells (DCs) are specialized antigen‐presenting cells that are crucial for maintaining self‐tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC‐based immunotherapy faces challenges that include limited availability, immune escape in tumors, immunosuppression in the tumor ...
Min-Seon Song, Ji-Hee Nam, Kyung-Eun Noh, Dae-Seog Lim   +3 more
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion.

, 2006
In contrast to MHC molecules, which present peptides, the CD1 molecules have been discovered to present lipid Ags to T cells. CD1-restricted T lymphocytes have been recently associated with resistance to virus infection.
Martin J. Raftery, Stefan H. E. Kaufmann, Raftery, Martin J, Kaufmann, Stefan H. E., Winau, Florian, Raftery, Martin J., Günther Schönrich, Kaufmann, Stefan HE, Ulrich E. Schaible, Schönrich, Günther, Florian Winau, Schaible, Ulrich E, Schaible, Ulrich E.   +12 more
core   +1 more source

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Frontiers in Immunology, 2019
Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines.
Xi Zen Yap, Xi Zen Yap, Rachel J. Lundie, Gaoqian Feng, Gaoqian Feng, Joanne Pooley, James G. Beeson, James G. Beeson, James G. Beeson, James G. Beeson, Meredith O'Keeffe, Meredith O'Keeffe   +11 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dendritic calcium accumulation associated with direction-selective adaptation in visual motion-sensitive neurons in vivo [PDF]

, 2000
Kurtz R, Dürr V, Egelhaaf M. Dendritic calcium accumulation associated with direction-selective adaptation in visual motion-sensitive neurons in vivo. Journal of Neurophysiology.
Egelhaaf, Martin ; https://orcid.org/, Rafael Kurtz, Martin Egelhaaf, Martin Egelhaaf Dendritic Calcium, Kurtz, Rafael, Dürr, Volker ; https://orcid.org/, Volker Dürr   +6 more
core   +1 more source

Dendritic Cell and Regulatory T Cell numbers in relation to Breast Cancer Progression and Metastasis [PDF]

International Journal of Medical Arts
Background: Breast cancer ranks as the second cause of cancer-related deaths in Egypt. Numerous immunomodulatory pathways underscore the immune system’s involvement in cancer prognosis.
Walaa Ashry, Amal Ayoub, Azza Ghanem, Amany Tawfeik, Effat Hassan   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source