Results 51 to 60 of about 783,013 (308)

Dendritic cells during Epstein Barr virus infection

Frontiers in Microbiology, 2014
Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This -herpesvirus infects primarily human B and epithelial cells, but has been reported to be sensed ...
Christian eMunz
doaj   +1 more source

Immunogenicity of targeted lentivectors [PDF]

, 2014
To increase the safety and possibly efficacy of HIV-1 derived lentivectors (LVs) as an anti-cancer vaccine, we recently developed the Nanobody (Nb) display technology to target LVs to antigen presenting cells (APCs).
Adotévi, Bennett, Bevan, Bhardwaj, Bhardwaj, Bhardwaj, Blander, Bonehill, Bonehill, Breckpot, Breckpot, Breckpot, Charleston, Chuah, Collins, Collins, Collins, Collins, Cosset, Diebold, Donckier, Eggermont, Enk, Figdor, Gajewski, Garcia, Groettrup, Inaba, Kast, Lahoutte, Lévy, McCullough, Medzhitov, Melief, Mellman, Mortha, Moser, Moser, Munn, Naldini, Neyns, Noguiez-Hellin, Nussenzweig, Palena, Raes, Reis e Sousa, Reiser, Reiser, Richardson, Romani, Roncarolo, Sakuma, Schroyens, Semesyuk, Song, Storm, Thielemans, Thielemans, Thielemans, Thielemans, Torretta, Turk, Van Kooyk, Wang, Wang, Yamaguchi, Yewdell, Yu   +67 more
core   +3 more sources

Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study

Respiratory Research, 2010
Background Abnormal immune responses are believed to be highly relevant in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dendritic cells provide a critical checkpoint for immunity by their capacity to both induce and suppress immunity.
Yi Eunhee S, Kottom Theodore J, Lamont Jeffrey, Walters Paula R, Vassallo Robert, Limper Andrew H   +5 more
doaj   +1 more source

General features of the retinal connectome determine the computation of motion anticipation [PDF]

, 2015
Motion anticipation allows the visual system to compensate for the slow speed of phototransduction so that a moving object can be accurately located.
Asari, Baylor, Berry, Bischofberger, Blitz, Bollmann, Bonin, Borst, Branco, Branco, Briggman, Bölinger, Cafaro, Calkins, Calkins, Chen, Demb, Dreosti, Esposti, Freed, Gleeson, Gollisch, Goodale, Gouras, Haider, Hao, Hausselt, Haverkamp, Helmstaedter, Hines, Hitchcock, HUBEL, Isaacson, Jakobs, Jarsky, Johnston, Koch, Koizumi, Kolb, Kolb, Kolb, Koontz, Kuzmiski, Lee, Leonardo, Levick, Liu, London, Lukasiewicz, MacNeil, Magee, Malpeli, Manookin, Marshak, Marshak, Masland, Miller, Münch, Nikolaev, Odermatt, Oesch, Olveczky, Owczarzak, Pouille, Quiroga, RALL, Rieke, Roska, Schachter, Schwartz, Schwartz, Sivyer, Smith, Talbot, Tanaka, Taylor, Trenholm, Weber, West, Xu, Yonehara, Zhu   +81 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Immunomodulatory effects of human umbilical cord wharton's Jelly-Derived mesenchymal stem cells on differentiation, maturation and endocytosis of monocyte-derived dendritic cells [PDF]

, 2013
The Wharton's jelly of the umbilical cord is believed to be a source of mesenchymal stem cells (MSCs) which can be therapeutically applied in degenerative diseases.
Bonab, M.M., Hadjati, J., Latifpour, M., Masoud, A., Nicknam, M.H., Nikbin, B., Saeidi, M., Shakiba, Y.   +7 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Chemoresistance of human monocyte-derived dendritic cells is regulated by IL-17A. [PDF]

PLoS ONE, 2013
Dendritic cells initiate adaptive immune responses, leading either to control cancer by effector T cells or to exacerbate cancer by regulatory T cells that inhibit IFN-γ-mediated Th1-type response.
Selma Olsson Åkefeldt, Carine Maisse, Alexandre Belot, Marlène Mazzorana, Giulia Salvatore, Nathalie Bissay, Pierre Jurdic, Maurizio Aricò, Chantal Rabourdin-Combe, Jan-Inge Henter, Christine Delprat   +10 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity

Nature Communications
Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlighting the need ...
Louise Gorline, Fillipe Luiz Rosa do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vetillard, Aboubacar Sidiki K Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, Zeina Abou Nader, Judith Weber, Hannah Theobald, Matthieu Collin, Joseph Calmette, Giorgio Anselmi, Flavia Fico, Florent Ginhoux, Laleh Majlessi, Emmanuel L. Gautier, Loredana Saveanu, Julie Helft, Marc Dalod, Mathilde Dusseaux, James P. Di Santo, Stéphanie Hugues, Pierre Guermonprez   +31 more
doaj   +1 more source