Results 91 to 100 of about 94,485 (200)
Sampling issues in quantitative analysis of dendritic spines morphology
BMC Bioinformatics, 2012 Background Quantitative analysis of changes in dendritic spine morphology has become an interesting issue in contemporary neuroscience. However, the diversity in dendritic spine population might seriously influence the result of measurements in which ...
Ruszczycki Błażej +6 more
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Dendritic Spines and Distributed Circuits [PDF]
Neuron, 2011 Dendritic spines receive most excitatory connections in pyramidal cells and many other principal neurons. But why do neurons use spines, when they could accommodate excitatory contacts directly on their dendritic shafts? One suggestion is that spines serve to connect with passing axons, thus increasing the connectivity of the dendrites.
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Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
Scientific Reports, 2017 It is well established that visual deprivation has a profound impact on the responsiveness of neurons in the developing visual cortex. The effect of visual deprivation on synaptic connectivity remains unclear. Using transcranial two-photon microscopy, we
Yanmei Zhou, Baoling Lai, Wen-Biao Gan
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Neural Plasticity, 2012 Activation of TrkB receptors by brain-derived neurotrophic factor (BDNF) followed by MAPK/ERK signaling increases dendritic spine density and the proportion of mature spines in hippocampal CA1 pyramidal neurons. Considering the opposing actions of p75NTR
Christopher A. Chapleau +1 more
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C. elegans neurons have functional dendritic spines
eLife, 2019 Dendritic spines are specialized postsynaptic structures that transduce presynaptic signals, are regulated by neural activity and correlated with learning and memory. Most studies of spine function have focused on the mammalian nervous system.
Andrea Cuentas-Condori +5 more
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, 2019 Recent advances in electron microscopy have enabled the imaging of single cells in 3D at nanometer length scale resolutions. An uncharted frontier for in silico biology is the ability to simulate cellular processes using these observed geometries ...
Amaro, Rommie E. +7 more
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Actin cytoskeleton in dendritic spine
Folia Pharmacologica Japonica, 2007 樹状突起スパインは脳内の主要な興奮性シナプス後部であり，その形態および構成タンパク質の可塑的変化は学習記憶などの高次機能に重要である．スパイン内の構造体としては，シナプス後部肥厚（PSD）とアクチン細胞骨格があり，スパインの形態変化は主にアクチン細胞骨格により制御されている．スパイン内ではその頭部と頸部でアクチン線維の構造が異なることに加えて，頭部の中でもシナプス直下のPSD近傍と細胞質の中心領域でアクチン結合タンパク質の分布が異なる．したがって，スパインは3種類の性質の異なるアクチン細胞骨格によって構成されていると考えられる．アクチンを脱重合させると，多くのスパイン構成タンパク質の局在が不安定化し，スパイン形態もフィロポディア様に変化する．従って，アクチン細胞骨格がスパイン形態の形成 ...
Kenji, Hanamura, Tomoaki, Shirao
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EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
eLife, 2019 Vascular endothelial growth factor (VEGF) is an angiogenic factor that play important roles in the nervous system, although it is still unclear which receptors transduce those signals in neurons.
Eva Harde +8 more
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Network Plasticity as Bayesian Inference
, 2015 General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing.
Habenschuss, Stefan +3 more
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