Results 91 to 100 of about 591,136 (270)
PLoS Biology, 2023 Dendritic spines, the tiny and actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain that control synaptic activity and plasticity.
Hsiao-Tang Hu +6 more
doaj +1 more source
A Upf3b-mutant mouse model with behavioral and neurogenesis defects. [PDF]
, 2018 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts.
Cook-Andersen, H +14 more
core +1 more source
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
Nature Communications, 2016 Imbalanced protein homeostasis, such as excessive protein synthesis and protein aggregation, is a pathogenic hallmark of a range of neurological disorders. Here, using expression of mutant proteins, a knockdown approach and disease mutation knockin mice,
Yu-Tzu Shih, Y. Hsueh
semanticscholar +1 more source
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
Neurobiology of Disease, 2009 Senile plaque-associated changes in neuronal connectivity such as altered neurite trajectory, dystrophic swellings, and synapse and dendritic spine loss are thought to contribute to cognitive dysfunction in Alzheimer's disease and mouse models ...
Tara L. Spires-Jones +7 more
doaj +1 more source
Geometric principles of second messenger dynamics in dendritic spines. [PDF]
, 2019 Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state.
Bartol, Thomas M +4 more
core +1 more source
Nerve Conduction Through Dendrites via Proton Hopping [PDF]
, 2017 Background: In our previous studies of nerve conduction conducted by proton hopping, we have considered the axon, soma, synapse and the nodes of Ranvier.
Kier, Lemont B.
core +2 more sources
Control of Dendritic Spine Morphological and Functional Plasticity by Small GTPases
Journal of Neural Transplantation and Plasticity, 2016 Structural plasticity of excitatory synapses is a vital component of neuronal development, synaptic plasticity, and behaviour. Abnormal development or regulation of excitatory synapses has also been strongly implicated in many neurodevelopmental ...
Kevin M. Woolfrey, D. Srivastava
semanticscholar +1 more source
Microtubules in Dendritic Spine Development [PDF]
The Journal of Neuroscience, 2008 It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation.
Jiaping, Gu +2 more
openaire +2 more sources
Biological Research, 2023 Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain.
Qiaoyun Wu +10 more
doaj +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources