Results 111 to 120 of about 591,136 (270)
Frontiers in NutritionBackgroundObesity is associated with cognitive function impairment. We previously found that male, but not female, mice have poorer performance in learning and memory tasks and impaired hippocampal synaptic plasticity after long-term high-fat diet (HFD ...
Shu-Fang Teng +13 more
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Journal of Biomedical Science, 2020 Background Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morphology.
Hsiao-Tang Hu +2 more
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, 2019 Recent advances in electron microscopy have enabled the imaging of single cells in 3D at nanometer length scale resolutions. An uncharted frontier for in silico biology is the ability to simulate cellular processes using these observed geometries ...
Amaro, Rommie E. +7 more
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Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage
Journal of Neuroscience, 2015 The elimination of dendritic spine synapses is a critical step in the refinement of neuronal circuits during development of the cerebral cortex. Several studies have shown that activity-induced shrinkage and retraction of dendritic spines depend on ...
I. S. Stein, J. A. Gray, K. Zito
semanticscholar +1 more source
Sampling issues in quantitative analysis of dendritic spines morphology
BMC Bioinformatics, 2012 Background Quantitative analysis of changes in dendritic spine morphology has become an interesting issue in contemporary neuroscience. However, the diversity in dendritic spine population might seriously influence the result of measurements in which ...
Ruszczycki Błażej +6 more
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Nature Communications, 2015 Neuroimaging has provided compelling data about the brain. Yet the underlying mechanisms of many neuroimaging techniques have not been elucidated. Here we report a voxel-based morphometry (VBM) study of Thy1-YFP mice following auditory fear conditioning ...
O. Keifer +10 more
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Dendritic Spines and Distributed Circuits [PDF]
Neuron, 2011 Dendritic spines receive most excitatory connections in pyramidal cells and many other principal neurons. But why do neurons use spines, when they could accommodate excitatory contacts directly on their dendritic shafts? One suggestion is that spines serve to connect with passing axons, thus increasing the connectivity of the dendrites.
openaire +2 more sources
Network Plasticity as Bayesian Inference
, 2015 General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing.
Habenschuss, Stefan +3 more
core +3 more sources
Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
Scientific Reports, 2017 It is well established that visual deprivation has a profound impact on the responsiveness of neurons in the developing visual cortex. The effect of visual deprivation on synaptic connectivity remains unclear. Using transcranial two-photon microscopy, we
Yanmei Zhou, Baoling Lai, Wen-Biao Gan
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