Results 101 to 110 of about 230,109 (316)

RNAi-Induced Gene Silencing against Chikungunya and COVID-19: What Have We Learned So Far, and What Is the Way Forward?

Viruses
RNA interference (RNAi) is a process in which small RNA molecules (such as small interfering RNAs or siRNAs) bind to specific messenger RNAs (mRNAs), leading to its degradation and inhibition of protein synthesis.
Kingshuk Panda, Kalichamy Alagarasu, Rajarshee Tagore, Mandar Paingankar, Satyendra Kumar, Manish Kumar Jeengar, Sarah Cherian, Deepti Parashar   +7 more
doaj   +1 more source

Multiple introductions of dengue virus strains contribute to dengue outbreaks in East Kalimantan, Indonesia, in 2015–2016

Virology Journal, 2019
Background Dengue fever is a febrile disease caused by dengue virus (DENV), which affects people throughout the tropical and subtropical regions of the world, including Indonesia.
R. Tedjo Sasmono, Lily Pertiwi Kalalo, Suryani Trismiasih, Dionisius Denis, Benediktus Yohan, Rahma F. Hayati, Sotianingsih Haryanto   +6 more
doaj   +1 more source

Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia

Gates Open Research, 2019
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and ...
P. Ryan, Andrew P Turley, G. Wilson, T. Hurst, Kate Retzki, Jack Brown-Kenyon, Lauren Hodgson, Nichola Kenny, Helen Cook, B. Montgomery, C. Paton, S. Ritchie, A. Hoffmann, N. Jewell, S. Tanamas, K. Anders, C. Simmons, S. O'Neill   +17 more
semanticscholar   +1 more source

Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Mid‐trimester pregnancy loss (MTL), defined as a pregnancy loss occurring between 14 + 0 and 21 + 6 weeks of gestation, causes significant physical and emotional distress to women and presents clinical challenges to healthcare professionals. It is acknowledged that in low‐resource settings, this guideline might be applicable to births up to 28 
Caroline E. Fox, Rosinder Kaur, Kugajeevan Vigneswaran, Rachel Small, Jenny Carter, Keelin O'Donoghue, Alexander E. P. Heazell, Anna L. David, Nigel Simpson, Angharad Care, Lisa Starrs, Andrew Shennan, Catalina María Valencia González, Priya Soma‐Pillay, Leah Fitzsimmons, Adam J. Devall, Arri Coomarasamy, Mid‐trimester Pregnancy Loss Guideline Consensus Panel, Owen Arthurs, Ruth Bender‐Atik, Phil Bennett, Kirstien Boelaert, Elizabeth Bonney, Leanna Brace, Naomi Carlisle, Davide Casagrandi, Manju Chandiramani, Carolyn Chiswick, Alexandra Emms, Stella Fielder, James Goadsby, Laura Goodfellow, Jim Gray, Jemma Johns, Emma Kirk, Will Lester, Sophie Mackay, Maria Memtsa, Katie Morris, Sunbal Mukhtar, Naimah Raza, Rita Sarquis, Neil Sebire, Lucy Smith, Lucy Spencer, Amos Tetteh, Natalie Woodhead   +46 more
wiley   +1 more source

Explorations on the antiviral potential of zinc and magnesium salts against chikungunya virus: implications for therapeutics

Frontiers in Cellular and Infection Microbiology
BackgroundChikungunya virus (CHIKV), which causes chikungunya fever, is an arbovirus of public health concern with no approved antiviral therapies. A significant proportion of patients develop chronic arthritis after an infection.
Kusuma Sai Davuluri, Shridhar Shukla, Mahadeo Kakade, Sarah Cherian, Sarah Cherian, Kalichamy Alagarasu, Kalichamy Alagarasu, Deepti Parashar, Deepti Parashar   +8 more
doaj   +1 more source

Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

Science, 2019
Zika dynamics in South America The infection dynamics of Zika virus (ZIKV) are difficult to characterize. Many ZIKV infections are asymptomatic, and the clinical presentation of ZIKV is nonspecific. Rodriguez-Barraquer et al.
I. Rodríguez-Barraquer, F. Costa, E. Nascimento, N. Nery, Priscila M. S. Castanha, G. Sacramento, J. Cruz, M. Carvalho, Daiana De Olivera, José E. Hagan, Haritha Adhikarla, Elsio A. Wunder, Danilo F. Coêlho, Sasha R. Azar, S. Rossi, N. Vasilakis, S. Weaver, G. Ribeiro, Á. Balmaseda, E. Harris, M. Nogueira, M. Reis, E. Marques, D. Cummings, A. Ko   +24 more
semanticscholar   +1 more source

GISDD: A comprehensive global integrated sequence and genotyping database platform for dengue virus, facilitating a stratified coordinated surveillance strategy

iMetaOmics, EarlyView.
GISDD, the Global Integrated Sequence and Genotyping Database for Dengue Virus (DENV), provides an integrated online analysis platform encompassing tools such as GISDDrlearn, GISDDprimer, and GISDDref, enabling swift identification and tracing of well‐established DENV genotypes, subgenotypes, and clades, thereby facilitating a stratified global ...
Xiang Guo, Pingying Teng, Ziyao Li, Liqiang Li, Xiaohua Liu, Xiaoqing Zhang, Yuji Wang, Minling Hu, Wenwen Ren, Shu Zeng, Haiyang Chen, Liu Ge, Shihan Liu, Zhiqiang Peng, Jiufeng Sun, Xin Zhang, Lei Luo, Jie Peng, Benyun Shi, Rangke Wu, Jiming Liu, Fuchun Zhang, Xiao‐Guang Chen, Tong Chen, Xiaohong Zhou   +24 more
wiley   +1 more source

Development of MVA-d34 Tetravalent Dengue Vaccine: Design and Immunogenicity [PDF]

, 2023
R. R. Mintaev, Д. В. Глазкова, Olga V. Orlova, Georgiy M. Ignatyev, A. S. Oksanich, German A. Shipulin, E. V. Bogoslovskaya   +6 more
openalex   +1 more source

Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses

Gates Open Research, 2018
Background: A number of new technologies are under development for the control of mosquito transmitted viruses, such as dengue, chikungunya and Zika that all require the release of modified mosquitoes into the environment.
S. O'Neill, P. Ryan, Andrew P Turley, G. Wilson, Kate Retzki, I. Iturbe-Ormaetxe, Yi Dong, Nichola Kenny, C. Paton, S. Ritchie, Jack Brown-Kenyon, Darren Stanford, Natalie Wittmeier, K. Anders, C. Simmons   +14 more
semanticscholar   +1 more source

Determining the efficacy of guppies and pyriproxyfen (Sumilarv® 2MR) combined with community engagement on dengue vectors in Cambodia: study protocol for a randomized controlled trial

Trials, 2017
Background Evidence on the effectiveness of low-cost, sustainable, biological vector-control tools for the Aedes mosquitoes is limited. Therefore, the purpose of this trial is to estimate the impact of guppy fish (guppies), in combination with the use of
John Hustedt, Dyna Doum, Vanney Keo, Sokha Ly, BunLeng Sam, Vibol Chan, Neal Alexander, John Bradley, Didot Budi Prasetyo, Agus Rachmat, Shafique Muhammad, Sergio Lopes, Rithea Leang, Jeffrey Hii   +13 more
doaj   +1 more source