Results 121 to 130 of about 183,701 (268)

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Modelling the control strategies against dengue in Singapore. [PDF]

, 2007
Notified cases of dengue infections in Singapore reached historical highs in 2004 (9459 cases) and 2005 (13,817 cases) and the reason for such an increase is still to be established.
LOPEZ, L. F., Coutinho, FAB, Lopez, LF, Ma, S, Coutinho, F.A.B., Burattini, M.N., Chow, A, Massad, E, COUTINHO, F. A. B., CHEN, M., MA, S., Goh, KT, MASSAD, E., Chen, M, Goh, K.T., CHOW, A., BURATTINI, M. N., GOH, K. T., Lopez, L.F., Burattini, MN   +19 more
core   +1 more source

Dengue epidemic alert thresholds for surveillance and decision-making in Puerto Rico: development and prospective application of an early warning system using routine surveillance data

BMJ Open
Objectives The Puerto Rico Department of Health (PRDH) seeks to identify dengue epidemics as early as possible with high specificity.Design Development and prospective application of an early warning system for dengue epidemics using routine historical ...
Gabriela Paz-Bailey, Zachary J Madewell, Maile B Thayer, Melissa Marzan-Rodriguez, Jomil Torres Aponte, Aidsa Rivera, Dania M Rodriguez, Kristyna Rysava, Laura E Adams, Michael A Johansson   +9 more
doaj   +1 more source

Dengue retinochoroiditis

Annals of Saudi Medicine, 2012
Dengue is a mosquito-borne infection caused by a flavivirus. I describe the ocular findings observed in two patients infected with dengue virus who presented with acute onset of loss of vision preceded by febrile illness, malaise, generalized fatigue headache, and maculopapular rash.
openaire   +3 more sources

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

What is the best way to diagnose Dengue haemorrhagic fever early? Routine application of ultrasound for early detection of Dengue haemorrhagic fever

International Journal of Infectious Diseases, 2020
L. Fernando, H. Wijesinghe, A. Pathmeswaran, D. Silva, M. Kumarihamy, T. Silva, R. Jayasuriya, D. Peiris, N. Jayasinghe, T. Somaratne   +9 more
doaj   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

DENGUE FEVER. [PDF]

The Lancet, 1872
n ...
openaire   +1 more source

Unmasking the Influence of Viral Micro‐RNAs on Host Immunity

Immunology &Cell Biology, EarlyView.
Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton, Bernadette M. Saunders   +1 more
wiley   +1 more source

Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review

Parasites & Vectors, 2014
Constant and extensive use of chemical insecticides has created a selection pressure and favored resistance development in many insect species worldwide.
Ana Paula B Silva, Joselita Maria M Santos, Ademir J Martins   +2 more
doaj   +1 more source