Results 31 to 40 of about 196,737 (184)

Drug repurposing approach against chikungunya virus: an in vitro and in silico study

Frontiers in Cellular and Infection Microbiology, 2023
The chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes mosquitoes. There are no licenced antivirals or vaccines for treatment or prevention. Drug repurposing approach has emerged as a novel concept to find alternative uses of therapeutics to
Bhagyashri Kasabe, Gunwant Ahire, Poonam Patil, Madhura Punekar, Kusuma Sai Davuluri, Mahadeo Kakade, Kalichamy Alagarasu, Deepti Parashar, Sarah Cherian   +8 more
doaj   +1 more source

Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study

Revista da Sociedade Brasileira de Medicina Tropical, 2012
INTRODUCTION: To analyze the liver dysfunction and evolution of signs and symptoms in adult dengue patients during a two-month follow-up period. METHODS: A prospective cohort study was conducted in Campos dos Goytacazes, Rio de Janeiro, Brazil, from ...
Ricardo Tristão-Sá, Claire Fernandes Kubelka, Eliana Zandonade, Sônia Maria Oliveira Zagne, Natally de Souza Maciel Rocha, Luiza Oliveira Zagne, Nathália Félix Araújo, Beatriz Amin, Flávia Fazoli, Luiz José de Souza, Oswaldo Gonçalves Cruz, Rivaldo Venâncio da Cunha, Delso do Nascimento, Íris Bucher Froes, Rita Maria Ribeiro Nogueira   +14 more
doaj   +1 more source

Identification of Novel Candidate CD8⁺ T Cell Epitopes of the SARS-CoV2 with Homology to Other Seasonal Coronaviruses

Viruses, 2021
Cross-reactive T cell immunity to seasonal coronaviruses (HCoVs) may lead to immunopathology or protection during SARS-CoV2 infection. To understand the influence of cross-reactive T cell responses, we used IEDB (Immune epitope database) and NetMHCpan ...
Pradeep Darshana Pushpakumara, Deshan Madhusanka, Saubhagya Dhanasekara, Chandima Jeewandara, Graham S. Ogg, Gathsaurie Neelika Malavige   +5 more
doaj   +1 more source

Isoselenourea‐Catalyzed Enantioselective Pyrazolo‐Heterocycle Synthesis Enabled by Self‐Correcting Amide and Ester Acylation

Angewandte Chemie, EarlyView.
A highly enantioselective isoselenourea catalyzed route to fused pyrazolo‐pyridone and ‐pyranone heterocycles has been developed. Mechanistic and computational studies highlight the significance of an intermediate amide or ester product derived from 1,2‐addition that can be diverted to the desired pathway through isoselenourea acylation.
Martha I. Prindl, Matthew T. Westwood, Alister S. Goodfellow, Aidan P. McKay, David B. Cordes, Michael Bühl, Andrew D. Smith   +6 more
wiley   +2 more sources

The impact of dengue on liver function as evaluated by aminotransferase levels

Brazilian Journal of Infectious Diseases
The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols.
Luiz José de Souza, Rita Maria Ribeiro Nogueira, Leandro Cordeiro Soares, Carlos Eduardo Cordeiro Soares, Bruno Fernandes Ribas, Felipe Pinto Alves, Fabíola Rodrigues Vieira, Felipe Eulálio Baldi Pessanha   +7 more
doaj   +1 more source

Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1,585 cases

Brazilian Journal of Infectious Diseases
INTRODUCTION: Type 3 dengue virus caused an extensive epidemic in the state of Rio de Janeiro in summer 2002. In some of the patients, it was found in an atypical form with increased aminotransferase levels and acute hepatitis.
Luiz José de Souza, José Galvão Alves, Rita Maria Ribeiro Nogueira, Carlos Gicovate Neto, Diogo Assed Bastos, Edno Wallace da Silva Siqueira, João Tadeu Damian Souto Filho, Thiago de Abreu Cezário, Carlos Eduardo Soares, Rodrigo da Costa Carneiro   +9 more
doaj   +1 more source

Integrated vector control of Aedes aegypti mosquitoes around target houses

Parasites & Vectors, 2018
Background The developing fetuses of pregnant women are at high risk of developing serious birth defects following Zika virus infections. We applied an Integrated Vector Control (IVC) approach using source reduction, larviciding, and mass trapping with ...
Roberto Barrera, Manuel Amador, Jorge Munoz, Veronica Acevedo   +3 more
doaj   +1 more source

Hemorrhagic encephalopathy in dengue shock syndrome: a case report

Brazilian Journal of Infectious Diseases
Dengue fever is the most important arboviral infection in the world, with an estimated 100 million cases per year and 2.5 billion people at risk.
Luiz José de Souza, André Luiz de Oliveira Martins, Paulo César Leitão Paravidini, Rita Maria Ribeiro Nogueira, Carlos Gicovate Neto, Diogo Assed Bastos, Edno Wallace da Silva Siqueira, Rodrigo da Costa Carneiro   +7 more
doaj   +1 more source

Predictive value of persistent NS1 antigen positivity beyond 3rd day for dengue haemorrhagic fever in Sri Lankan children

BMC Research Notes, 2019
Objective Dengue haemorrhagic fever (DHF) is a major public health concern responsible for significant morbidity in both adult and paediatric populations in Sri Lanka.
Mihira Manamperi, Bernard Deepal Wanniarachchi Jayamanne, Thilini Somaratne, Natasha Perera, LakKumar Fernando   +4 more
doaj   +1 more source

Comparison of clinical and laboratory characteristics between children and adults with dengue

Brazilian Journal of Infectious Diseases
Over the past several years, the epidemiological profile of dengue has been changing progressively and is currently characterized by an increase in the number of cases in children under 15 years of age.
Luiz José de Souza, Laís Bastos Pessanha, Laura Carvalho Mansur, Luiza Assed de Souza, Mariana Barbosa Tâmega Ribeiro, Monique do Vale da Silveira, João Tadeu Damian Souto Filho   +6 more
doaj   +1 more source