Results 71 to 80 of about 230,109 (316)

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine

Frontiers in Cellular and Infection Microbiology, 2020
In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus ...
R. Shukla, V. Ramasamy, Rajgokul K. Shanmugam, R. Ahuja, N. Khanna   +4 more
semanticscholar   +1 more source

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

Advanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka, Lenka Vaňková, Josef Sýkora, Věra Křížková, Jan Schwarz, Petr Bouř   +5 more
wiley   +1 more source

INHIBITORY ACTIVITY OF COBALT(II)–MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2

Indonesian Journal of Tropical and Infectious Disease, 2017
Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. Antidengue treatments are urgently required to control the emergence of dengue.
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati Setyawati, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Shuhai Ueda, Tomohiro Kotaki, Sri Sumarsih, Puspa Wardhani, Sri Subekti Bendryman, Aryati Aryati, Soegeng Soegijanto, Masanori Kameoka   +12 more
doaj   +1 more source

Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis

Gates Open Research, 2020
Background: Ae. aegypti mosquitoes stably transfected with the intracellular bacterium Wolbachia pipientis ( wMel strain) have been deployed for biocontrol of dengue and related arboviral diseases in multiple countries.
C. Indriani, W. Tantowijoyo, Edwige Rancès, B. Andari, Equatori Prabowo, Dedik Yusdi, M. R. Ansari, D. S. Wardana, E. Supriyati, Indah Nurhayati, Inggrid Ernesia, S. Setyawan, Iva Fitriana, E. Arguni, Yudiria Amelia, R. Ahmad, N. Jewell, S. Dufault, P. Ryan, Benjamin R. Green, Thomas F. McAdam, S. O'Neill, S. Tanamas, C. Simmons, K. Anders, A. Utarini   +25 more
semanticscholar   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study

Virology Journal
Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri, Rajnandini Ghanghav, Gunwant Ahire, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar   +6 more
doaj   +1 more source

FEVER AS INDICATOR TO SECONDARY INFECTION IN DENGUE VIRAL INFECTION

Indonesian Journal of Tropical and Infectious Disease, 2018
Dengue Virus Infections are distributed in tropical and sub-tropical regions and transmitted by the mosquitoes such as Aedes aegypti and Aedes albopictus.
Soegeng Soegijanto, Sufiandika Nuryandari, Siti Churrotin, Teguh Hari Sucipto   +3 more
doaj   +1 more source

Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus

PLoS Neglected Tropical Diseases, 2012
Background Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain.
O. Brady, P. Gething, S. Bhatt, J. Messina, J. Brownstein, A. Hoen, C. Moyes, A. Farlow, T. Scott, Simon Iain Hay   +9 more
semanticscholar   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

A case report of dengue haemorrhagic fever complicated with psoas haematoma requiring blood transfusion

BMC Infectious Diseases, 2019
Background Dengue fever is a common infection with increasing numbers of patients affected. Muscle haematomas are a rare complication of dengue fever. In most cases haematomas resolve spontaneously. Case presentation We report a case of spontaneous psoas
Anne Thushara Matthias, Sanduni Apsara, Apsara Epa   +2 more
doaj   +1 more source