Results 71 to 80 of about 384,257 (331)

An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8+ T cells and antibody when expressed from modified vaccinia Ankara [PDF]

, 2014
Dengue is a global public health concern and this is aggravated by a lack of vaccines or antiviral therapies. Despite the well-known role of CD8(+) T cells in the immunopathogenesis of Dengue virus (DENV), only recent studies have highlighted the ...
Coelho, Fabiana M., da Fonseca, Flávio G., Flesch, Inge E. A., Pinho, Tânia M. G., Quinan, Bárbara R., Tscharke, David C.   +5 more
core   +1 more source

Comparison of clinical and laboratory characteristics between children and adults with dengue

Brazilian Journal of Infectious Diseases
Over the past several years, the epidemiological profile of dengue has been changing progressively and is currently characterized by an increase in the number of cases in children under 15 years of age.
Luiz José de Souza, Laís Bastos Pessanha, Laura Carvalho Mansur, Luiza Assed de Souza, Mariana Barbosa Tâmega Ribeiro, Monique do Vale da Silveira, João Tadeu Damian Souto Filho   +6 more
doaj   +1 more source

Integrated vector control of Aedes aegypti mosquitoes around target houses

Parasites & Vectors, 2018
Background The developing fetuses of pregnant women are at high risk of developing serious birth defects following Zika virus infections. We applied an Integrated Vector Control (IVC) approach using source reduction, larviciding, and mass trapping with ...
Roberto Barrera, Manuel Amador, Jorge Munoz, Veronica Acevedo   +3 more
doaj   +1 more source

Predictive value of persistent NS1 antigen positivity beyond 3rd day for dengue haemorrhagic fever in Sri Lankan children

BMC Research Notes, 2019
Objective Dengue haemorrhagic fever (DHF) is a major public health concern responsible for significant morbidity in both adult and paediatric populations in Sri Lanka.
Mihira Manamperi, Bernard Deepal Wanniarachchi Jayamanne, Thilini Somaratne, Natasha Perera, LakKumar Fernando   +4 more
doaj   +1 more source

Detecting the impact of temperature on transmission of Zika, dengue, and chikungunya using mechanistic models

PLoS Neglected Tropical Diseases, 2017
Recent epidemics of Zika, dengue, and chikungunya have heightened the need to understand the seasonal and geographic range of transmission by Aedes aegypti and Ae. albopictus mosquitoes.
E. Mordecai, Jeremy M. Cohen, M. Evans, Prithvi Gudapati, L. Johnson, C. Lippi, Kerri L. Miazgowicz, C. Murdock, Jason Rohr, S. Ryan, V. Savage, Marta S. Shocket, Anna M. Stewart Ibarra, M. Thomas, Daniel P. Weikel   +14 more
semanticscholar   +1 more source

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine

Frontiers in Cellular and Infection Microbiology, 2020
In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus ...
R. Shukla, V. Ramasamy, Rajgokul K. Shanmugam, R. Ahuja, N. Khanna   +4 more
semanticscholar   +1 more source

A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2

Viruses, 2022
The rising incidence of dengue virus (DENV) infections in the tropical and sub-tropical regions of the world emphasizes the need to identify effective therapeutic drugs against the disease.
Madhura Punekar, Bhagyashri Kasabe, Poonam Patil, Mahadeo B. Kakade, Deepti Parashar, Kalichamy Alagarasu, Sarah Cherian   +6 more
doaj   +1 more source

Dengue and the heart

Cardiovascular Journal of Africa, 2021
Dengue is a neglected viral arthropod-borne tropical disease transmitted by the bite of infected Aedes spp. mosquitoes. It is responsible for a significant global burden of disease and corresponding socio-economic implications. There are four different virus serotypes, all of which are found predominantly in countries with tropical climates.
Araiza Garaygordobil, Diego, García Martínez, Carlos Eduardo, Burgos, Lucrecia María, Saldarriaga Giraldo, Clara I., Liblik, Kiera, Mendoza, Iván J., Martínez Sellés Oliveria Soares, Manuel, Scatularo, Cristhian Emmanuel, Farina, Juan María, Baranchuk, Adrian, Neglected Tropical Diseases and other Infectious Diseases affecting the Heart (the NET‐Heart) project   +10 more
openaire   +6 more sources

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Association of dengue virus‐specific polyfunctional T‐cell responses with clinical disease severity in acute dengue infection

Immunity, Inflammation and Disease, 2019
Introduction Although the role of dengue virus (DENV)‐specific T cells in the pathogenesis of acute dengue infection is emerging, the functionality of virus‐specific T cells associated with milder clinical disease has not been well studied.
Dulharie T. Wijeratne, Samitha Fernando, Laksiri Gomes, Chandima Jeewandara, Geethal Jayarathna, Yashoda Perera, Samurdhi Wickramanayake, Ananda Wijewickrama, Graham S. Ogg, Gathsaurie N. Malavige   +9 more
doaj   +1 more source