Results 71 to 80 of about 328,224 (312)
Presentation and Management of Addison's Disease in a 10‐Year‐Old Boy: A Case Report
iLABMED, EarlyView.ABSTRACT Addison's disease, or primary adrenal insufficiency, is a rare endocrine disorder characterized by impaired adrenal hormone production. We report a case of a 10‐year‐old boy with congenital adrenal hyperplasia and secondary Addison's disease on long‐term corticosteroid therapy who presented with recurrent non‐bilious vomiting, low‐grade fever,
Srinivasan Sivannan +4 more
wiley +1 more source
Curcuminoids amplify host innate antiviral immunity via the CRYAB‐RBM26 axis in viral infection
iMeta, EarlyView.DMC/CUR antagonize viral hijacking of host nucleic acid resources and finely regulate the induction and effector phases of the type I interferon (IFN‐I) pathway through the CRYAB‐RBM26 axis. This molecular axis serves as a key downstream regulator for DMC/CUR activation of the IFN‐I pathway.
Tingting Chen +18 more
wiley +1 more source
Time-scale analysis non-local diffusion systems, applied to disease models
, 2020 The objective of the present paper is to use the well known Ross-Macdonald models as a prototype, incorporating spatial movements, identifying different times scales and proving a singular perturbation result using a system of local and non-local ...
Oliva, Sergio +2 more
core
Detection of Insecticide Resistance in Aedes Aegypti to Organophosphate in Pulogadung, East Jakarta [PDF]
, 2015 Dengue Hemorrhagic Fever (DHF) is a major public health problem in Indonesia. Jakarta is a capital city with the highest number of dengue patients. Among sporadic endemic areas in Jakarta, Pulogadung, a district of East Jakarta, is one of endemic areas ...
Donanti, E. (Elita) +4 more
core
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.ABSTRACT Aedes aegypti, a critical vector for tropical diseases, poses significant challenges for studying its embryogenesis due to difficulties in removing its rigid chorion and achieving effective fixation for in situ hybridization. Here, we present novel methodologies for fixation, dechorionation, DAPI staining, and in situ hybridization, enabling ...
Renata Coutinho‐dos‐Santos +8 more
wiley +1 more source
Key Amino Acid Substitution for Infection-Enhancing Activity-Free Designer Dengue Vaccines
iScience, 2019 Summary: Dengue is a globally important disease caused by four serotypes of dengue virus. Dengue vaccine development has been hampered by antigenic cross-reactivity among serotypes, which potentially causes antibody-dependent enhancement of infection and
Atsushi Yamanaka, Eiji Konishi
doaj +1 more source
Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley +1 more source
Enhancement of Epidemiological Models for Dengue Fever Based on Twitter Data
, 2017 Epidemiological early warning systems for dengue fever rely on up-to-date epidemiological data to forecast future incidence. However, epidemiological data typically requires time to be available, due to the application of time-consuming laboratorial ...
Albinati, Julio +4 more
core +1 more source
Tropical Medicine and Infectious DiseaseBackground: Dengue, transmitted by Aedes spp. mosquitoes, poses significant public health challenges in Burkina Faso. This study investigated outbreak thresholds, utilizing historical data since 2018 to explore the climatic impacts on dengue transmission
John Otokoye Otshudiema +8 more
doaj +1 more source