Results 81 to 90 of about 306,371 (286)

Analysis of Gene Expression in Aedes aegypti Suggests Changes in Early Genetic Control of Mosquito Development

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
ABSTRACT Aedes aegypti, a critical vector for tropical diseases, poses significant challenges for studying its embryogenesis due to difficulties in removing its rigid chorion and achieving effective fixation for in situ hybridization. Here, we present novel methodologies for fixation, dechorionation, DAPI staining, and in situ hybridization, enabling ...
Renata Coutinho‐dos‐Santos, Danielle Santos, Lupis Ribeiro, Jonathan J. Mucherino‐Muñoz, Marcelle Uhl, Carlos Logullo, A. Mendonça‐Amarante, M. Fantappie, Rodrigo Nunes‐da‐Fonseca   +8 more
wiley   +1 more source

Dengue and Calcium

International Journal of Critical Illness and Injury Science, 2014
Dengue is potentially fatal unless managed appropriately. No specific treatment is available and the mainstay of treatment is fluid management with careful monitoring, organ support, and correction of metabolic derangement. Evidence with regards to the role of calcium homeostasis in dengue is limited.
Senaka Rajapakse, Mitrakrishnan Chrishan Shivanthan   +1 more
openaire   +4 more sources

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Global, Regional, National, and Local Burden of COVID‐19 With Inequality Analysis Across 920 Locations, 2020–2021

Med Research, EarlyView.
This study presents the first standardized assessment of the direct health burden of COVID‐19 across 920 locations worldwide during 2020 and 2021, covering five geographic levels: global, international regional, national, subnational, and local. Six key health measures, including incidence, prevalence, mortality, disability‐adjusted life years (DALYs),
Dan Shan, Wenyi Jin, Fei Li, You Zeng, Ruiling Xie, Chengliang Yang, Qingjia Zeng, Yi Chen, Haowei Wang, Christine Linehan, Claire Chenwen Zhong, Qiaoyu Shao, Xiaozhu Liu, Wen Chen, Tongrui Shang, Dong Wang, Yuanyuan Wan, Ningning Wu, Minzhi Lv, Zhihui Li, Yue Qiu, Wei Wang, Xian Shao, Ruhai Bai, Lili Zheng, Baozhen Huang, Weize Xu, Changchang Li, Zimeng Wu, Guangyao Cai, Yuanyuan Chen, Ying Wang, Shuang Hu, Liang Zhang, Lerong Chen, Jianhua Huang, Scott J. Tebbutt, Ting Luo, Queran Lin, Salman Rawaf, Azeem Majeed, for the GBD 2021 Global‐to‐Local COVID‐19 Burden Monitoring Taskforce   +41 more
wiley   +1 more source

Diagnostics for optimised dengue surveillance: a qualitative focus group study to investigate user experience and requirements in Thailand

BMJ Open
Objectives Effective, real-time surveillance of dengue may provide early warning of outbreaks and support targeted disease-control intervention but requires widespread accurate diagnosis and timely case reporting.
Raheelah Ahmad, Alison Holmes, Pantelis Georgiou, Paul Arkell, Sanhapon Ketklao, Adisak Songjaeng, Dumrong Mairiang, Jesus Rodriguez-Manzano, Prida Malasit, Panisadee Avirutnan, Saranath Lawpoolsri   +10 more
doaj   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Modeling and Optimal Control Applied to a Vector Borne Disease

, 2012
A model with six mutually-exclusive compartments related to Dengue disease is presented. In this model there are three vector control tools: insecticides (larvicide and adulticide) and mechanical control.
Monteiro, M. Teresa T., Rodrigues, Helena Sofia, Torres, Delfim F. M.   +2 more
core  

On the Dynamics of Dengue Virus type 2 with Residence Times and Vertical Transmission

, 2016
A two-patch mathematical model of Dengue virus type 2 (DENV-2) that accounts for vectors' vertical transmission and between patches human dispersal is introduced. Dispersal is modeled via a Lagrangian approach.
Bichara, Derdei, Castillo-Chavez, Carlos, Holechek, Susan A., Murillo, Anarina L., Velazquez-Castro, Jorge   +4 more
core   +2 more sources

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease
Background Pattern recognition receptors (PRRs) are the receptors of the innate immune system that play a vital role in initiating innate immune response.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
doaj   +1 more source