Results 111 to 120 of about 43,902 (289)

Routine use of denosumab for prevention of skeletal-related events in patients with bone metastases from prostate carcinoma in Bulgaria: a prospective observational study

Biotechnology & Biotechnological Equipment
Bulgarian real-world data on denosumab use for the prevention of skeletal-related events (SREs) associated with bone metastases (BM) from prostate cancer (PC) are lacking.
Antoaneta Tomova, Valentina Ianakieva, Katja Bjorklof, Adrian Olszewski, Miglena Petrova   +4 more
doaj   +1 more source

The effect of denosumab on pedicle screw fixation: a prospective 2-year longitudinal study using finite element analysis

Journal of Orthopaedic Surgery and Research, 2021
Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis.
Soji Tani, Koji Ishikawa, Yoshifumi Kudo, Koki Tsuchiya, Akira Matsuoka, Hiroshi Maruyama, Haruka Emori, Ryo Yamamura, Chikara Hayakawa, Masaya Sekimizu, Yusuke Oshita, Tomoyuki Ozawa, Toshiyuki Shirahata, Takashi Nagai, Tomoaki Toyone, Katsunori Inagaki   +15 more
doaj   +1 more source

Osteoporosis drug treatment: duration and management after discontinuation. A position statement from the SVGO/ASCO. [PDF]

, 2017
Antiosteoporotic drugs are recommended in patients with fragility fractures and in patients considered to be at high fracture risk on the basis of clinical risk factors and/or low bone mineral density.
Aubry-Rozier, B., Birkhäuser, M., Bischoff-Ferrari, H.A., Ferrari, S., Frey, D., Kressig, R.W., Lamy, O., Lippuner, K., Meier, C., Stute, P., Suhm, N., Uebelhart, B.   +11 more
core   +4 more sources

Dental Implants in Medically Compromised Patients Undergoing or After Receiving Anti‐Resorptive or Radiotherapy: Retrospective Clinical and Radiographic Data

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objective and Aim A retrospective study to evaluate the clinical and radiological outcomes of dental implants placed in compromised patients who have undergone antiresorptive therapy (AR) or head and neck radiotherapy (IR). Material and Methods Dental implant placement was evaluated in compromised patients undergoing or after receiving AR/IR ...
Christian Mertens, Fabian Staudinger, Maximilian Smielowski, Thomas Rückschloss, Gregor Schnug, Jürgen Hoffmann, Oliver Ristow   +6 more
wiley   +1 more source

Novel genetic models of osteoporosis by overexpression of human rankl in transgenic mice [PDF]

, 2014
Receptor activator of NF-KB ligand (RANKL) plays a key role in osteoclast-induced bone resorption across a range of degenerative bone diseases, and its specific inhibition has been recently approved as a treatment for women with postmenopausal ...
Bonnet, Nicolas, Dacquin, Romain, Douni, Eleni, Ferrari, Serge, Han, Chun-Ya, Jurdic, Pierre, Kostenuik, Paul, Niti, Alexandra, Rinotas, Vagelis, Stolina, Marina   +9 more
core   +2 more sources

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Denosumab in men receiving androgen-deprivation therapy for prostate cancer. [PDF]

, 2009
Androgen-deprivation therapy is well-established for treating prostate cancer but is associated with bone loss and an increased risk of fracture. We investigated the effects of denosumab, a fully human monoclonal antibody against receptor activator of ...
Denosumab, HALT Prostate Cancer Study Group, Egerdie, B, Feldman, R, Goessl, C, Heracek, J, Hernández Toriz, N, Ke, C, Kupic, A, Leder, BZ, Saad, F, Smith, MR, Szwedowski, M, Tammela, TL   +12 more
core   +1 more source

Major revision version 13.0 of the European AIDS Clinical Society guidelines 2025

HIV Medicine, EarlyView.
Abstract Background The European AIDS Clinical Society (EACS) guidelines were revised for the 21st time in 2025, with updates covering all aspects of HIV care. Key Points of the Guidelines Update The structure of the guidelines has been reorganized into two parts: Part I focuses on the management and prevention of HIV and related infections, and Part ...
Juan Ambrosioni, Laura I. Levi, Jasmini Alagaratnam, Abiu Sempere, Andrea Mastrangelo, Paolo Paioni, Cristina Mussini, Catia Marzolini, Susanne Dam Nielsen, Charles Béguelin, Steven Welch, Anna Koval, Luis Mendao, Alasdair Bamford, Alexandra Calmy, Giovanni Guaraldi, Cristiana Oprea, Esteban Martínez, Jürgen K. Rockstroh, The EACS Governing Board   +19 more
wiley   +1 more source

Effects of 3-year denosumab treatment on hip structure in Japanese postmenopausal women and men with osteoporosis

Bone Reports, 2017
Denosumab, a human monoclonal antibody against RANK ligand, is shown to have strong anti-fracture effects in Japanese osteoporosis patients. However, there have been no data showing actions on Japanese bone architecture.
Teruki Sone, Naohiro Kon, Kenneth W. Gaither, Naoki Okubo, Taisuke Osakabe, Yutaka Nakayama, Masao Fukunaga, Masako Ito, Toshitaka Nakamura   +8 more
doaj   +1 more source

Physicians’ Preferences for Bone Metastases Drug Therapy in the United States [PDF]

, 2015
ObjectiveSeveral characteristics of bone-targeted agents are considered when making treatment decisions. This study evaluated physicians’ therapy preferences for preventing skeletal-related events (SREs) in patients with bone metastases secondary to ...
Arellano, Jorge, Hauber, A. Brett, Mohamed, Ateesha F., Gonzalez, Juan Marcos, Collins, Helen, Hechmati, Guy, Gatta, Francesca, Qian, Yi   +7 more
core   +1 more source