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Eculizumab in a Patient with Dense-Deposit Disease
New England Journal of Medicine, 2012This letter indicates that in a patient with long-standing dense-deposit disease, a variant of membranoproliferative glomerulonephritis, eculizumab can be useful in the resolution of the nephrotic syndrome.
Erica Daina +2 more
exaly +3 more sources
New England Journal of Medicine, 2014
To the Editor: Dense-deposit disease is a complement-mediated disorder characterized by a proliferative glomerulonephritis, bright capillary-wall C3 staining on immunofluorescence microscopy, and large intramembranous osmiophilic dense deposits that markedly thicken the glomerular capillary walls.1,2 The underlying pathophysiology — fluid-phase ...
Sanjeev Sethi +2 more
exaly +3 more sources
To the Editor: Dense-deposit disease is a complement-mediated disorder characterized by a proliferative glomerulonephritis, bright capillary-wall C3 staining on immunofluorescence microscopy, and large intramembranous osmiophilic dense deposits that markedly thicken the glomerular capillary walls.1,2 The underlying pathophysiology — fluid-phase ...
Sanjeev Sethi +2 more
exaly +3 more sources
Dense deposit disease and the factor H H402 allele
Clinical and Experimental Nephrology, 2008 Herein, we describe the case of an 8-year-old boy who presented with a nephritic nephrotic syndrome. His laboratory investigation was significant for a persistently low serum complement 3 level. A renal biopsy was performed, based on which, he was diagnosed with dense deposit disease/membranoproliferative glomerulonephritis type II (DDD/MPGN II).
Lau, Keith K. +3 more
openaire +4 more sources
Eculizumab for the Treatment of Dense-Deposit Disease
New England Journal of Medicine, 2012Dysregulation of the alternative complement pathway plays a pathogenic role in dense-deposit disease (also known as membranoproliferative glomerulonephritis type II). This letter reports the use of eculizumab in a patient with this disease.
Marina Vivarelli +2 more
exaly +2 more sources
Dense deposit disease associated with multiple myeloma
Clinical Nephrology, 2018 Dense deposit disease (DDD) is a very rare pathological finding associated with activation of the final complement pathway. DDD has been rarely found in association with multiple myeloma (MM). Here we report a patient with MM presenting with renal failure, anemia, and bone pain. The renal biopsy showed DDD.
Ahmed M, Alkhunaizi +3 more
openaire +3 more sources
American Journal of Kidney Diseases, 1989 Twenty-seven patients presenting to the Royal Melbourne Hospital between 1968 and 1988 with mesangiocapillary glomerulonephritis type II with intramembranous dense deposits (dense-deposit disease, DDD) are analyzed.
Robert G Fassett +2 more
exaly +2 more sources
Kidney International, 2009 Dense Deposit Disease (DDD), or membranoproliferative glomerulonephritis type II, is a rare renal disease characterized by dense deposits in the mesangium and along the glomerular basement membranes that can be seen by electron microscopy. Although these
Sanjeev Sethi +2 more
exaly +2 more sources
‘Pauci-immune’ dense deposit disease
Molecular Immunology, 2011 C.M. Nester +5 more
openaire +2 more sources