Results 201 to 210 of about 16,635 (234)
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New England Journal of Medicine, 2014
To the Editor: Dense-deposit disease is a complement-mediated disorder characterized by a proliferative glomerulonephritis, bright capillary-wall C3 staining on immunofluorescence microscopy, and large intramembranous osmiophilic dense deposits that markedly thicken the glomerular capillary walls.1,2 The underlying pathophysiology — fluid-phase ...
Sanjeev Sethi +2 more
exaly +6 more sources
To the Editor: Dense-deposit disease is a complement-mediated disorder characterized by a proliferative glomerulonephritis, bright capillary-wall C3 staining on immunofluorescence microscopy, and large intramembranous osmiophilic dense deposits that markedly thicken the glomerular capillary walls.1,2 The underlying pathophysiology — fluid-phase ...
Sanjeev Sethi +2 more
exaly +6 more sources
Eculizumab for the Treatment of Dense-Deposit Disease
New England Journal of Medicine, 2012Dysregulation of the alternative complement pathway plays a pathogenic role in dense-deposit disease (also known as membranoproliferative glomerulonephritis type II). This letter reports the use of eculizumab in a patient with this disease.
Andrea Pasini +2 more
exaly +2 more sources
Dense deposit disease: new insights
Current Opinion in Nephrology and Hypertension, 2007Dense deposit disease is a rare but devastating disease primarily affecting children. This review focuses on new information regarding the pathophysiology of dense deposit disease, its appearance histopathologically, its relationship to other diseases including macular degeneration and acquired partial lipodystrophy and potential new therapies.The ...
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Spontaneous clinical improvement in dense deposit disease
Pediatric Nephrology, 2000The clinical course and 3-year follow-up of a female patient aged 11 years who presented with nephrotic syndrome and renal failure is described. The renal biopsy revealed type II membranoproliferative glomerulonephritis or dense deposit disease. She was treated with penicillin prophylaxis, frusemide and captopril, and was not given immunosuppression ...
S D, Marks, L, Rees
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APMIS, 1993
A membranoproliferative glomerulonephritis (MPGN) was diagnosed in 10 Yorkshire piglets, aged between 33 and 73 days, that had been submitted for routine autopsy. Matings of animals related to these piglets subsequently produced 15 offspring that had a membranoproliferative glomerulonephritis when examined at between 5 and 48 days of age. The principal
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A membranoproliferative glomerulonephritis (MPGN) was diagnosed in 10 Yorkshire piglets, aged between 33 and 73 days, that had been submitted for routine autopsy. Matings of animals related to these piglets subsequently produced 15 offspring that had a membranoproliferative glomerulonephritis when examined at between 5 and 48 days of age. The principal
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Dense deposit disease associated with multiple myeloma
Clinical Nephrology, 2018Dense deposit disease (DDD) is a very rare pathological finding associated with activation of the final complement pathway. DDD has been rarely found in association with multiple myeloma (MM). Here we report a patient with MM presenting with renal failure, anemia, and bone pain. The renal biopsy showed DDD.
Ahmed M, Alkhunaizi +3 more
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Recurrent dense deposit disease in renal allograft
Urology, 1978This report documents the recurrence of dense deposit disease in a renal allograft thirty-three days post-transplantation and stresses the usefulness of immunofluorescence in early detection.
A F, Jukkola +3 more
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Dense Deposit Disease: What Makes the Deposits Dense
Journal of the American Society of Nephrology, 2023Lilian M. Palma +2 more
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Granular dense deposit disease.
Laboratory investigation; a journal of technical methods and pathology, 1979During a retrospective study of dense deposit disease, we observed in three patients, unusual granular electron-dense deposits in the glomerular basement membrane in a laminar pattern. However, the distribution of these electron-dense deposits was similar to the distribution of the homogeneous, extremely electron-dense deposits of dense deposit disease.
J T, King +3 more
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Dense deposit disease and the factor H H402 allele
Clinical and Experimental Nephrology, 2008Herein, we describe the case of an 8-year-old boy who presented with a nephritic nephrotic syndrome. His laboratory investigation was significant for a persistently low serum complement 3 level. A renal biopsy was performed, based on which, he was diagnosed with dense deposit disease/membranoproliferative glomerulonephritis type II (DDD/MPGN II).
Lau, Keith K. +3 more
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