Results 191 to 200 of about 16,635 (234)

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

A Decade of C3 Glomerulopathy-A Nationwide Cohort Study. [PDF]

Kidney Int Rep
Overwijk RH, Kolbinger FR, Eijgelsheim M, Dekkers OM, Kronbichler A, Bajema IM.   +5 more
europepmc   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

C3 Glomerulopathy: recent advances and an update on management. [PDF]

J Bras Nefrol
Palma LMP, Barbosa MINH, Sethi S.
europepmc   +1 more source

Delineation of ventricular tachycardia isthmus using magnetic resonance imaging in a patient with idiopathic triglyceride deposit cardiomyovasculopathy. [PDF]

HeartRhythm Case Rep
Chishaki S, Amemiya K, Kamakura T, Ikeda Y, Sakata Y, Kusano K.   +5 more
europepmc   +1 more source

Prognostic factors for outcomes following needling and shockwave therapy in rotator cuff calcific tendinitis: A systematic review. [PDF]

Shoulder Elbow
Ade-Conde AM, Alkhatib L, Hantouly A, Ade-Conde OS, Olaonipekun E, Dagher D, Khan M.   +6 more
europepmc   +1 more source

Transmission Electron Microscopy Corneal Ultrastructure Study in Hematocornea of Corneal Transplant Graft. [PDF]

Diagnostics (Basel)
Curcă PF, Macovei L, Mușat O, Zemba M, Dinu V, Gherghiceanu M, Tătaru CI, Tătaru CP.   +7 more
europepmc   +1 more source

The Therapeutic Challenge in a Rare Case of Immunoglobulin A Type of Epidermolysis Bullosa Acquisita.

Indian J Dermatol
Gowda SK, Behera B, Sethy M, Ayyanar P.
europepmc   +1 more source

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Eculizumab in a Patient with Dense-Deposit Disease

New England Journal of Medicine, 2012
This letter indicates that in a patient with long-standing dense-deposit disease, a variant of membranoproliferative glomerulonephritis, eculizumab can be useful in the resolution of the nephrotic syndrome.
Marina Noris, Erica Daina, Giuseppe Remuzzi   +2 more
exaly   +3 more sources