Results 81 to 90 of about 564,000 (194)

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395

Platelets, 2018
The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation.
Annachiara Mitrugno, Rachel A. Rigg, Nicole B. Laschober, Anh T. P. Ngo, Jiaqing Pang, Craig D. Williams, Joseph E. Aslan, Owen J. T. McCarty   +7 more
doaj   +1 more source

Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects [PDF]

, 2013
We analyzed candidate platelet function disorder genes in 13 index cases with a history of excessive bleeding in association with a significant reduction in dense granule secretion and impaired aggregation to a panel of platelet agonists.
Morgan, N. V.; id_orcid, Bem, D., Collins, P. W., Makris, Michael, Watson, Steve P., Dawood, B., Lordkipanidze, M., Lordkipanidzé, Marie, Dawood, Ban, Daly, M. E., Motwani, J., Makris, M, Daly, Martina E., Macfarlane, K., Watson, S, Horner, K, Wilde, Jonathan T., Talks, K., Leo, Vincenzo C., Makris, M., Leo, V. C., Bem, D, Wilde, J. T., Collins, Peter William, Talks, K, Bem, Danai, Wilde, J, Motwani, Jayashree, Stockley, J, Horner, Kevin, Stockley, J., Lowe, Gillian C., Simpson, M. A., Stockley, Jacqueline, Leo, V, Talks, Katherine, Simpson, M, Macfarlane, K, Motwani, J, Lowe, G. C., Lordkipanidze, M, Morgan, Neil V., Watson, S. P.; id_orcid, Daly, M, Simpson, Michael A., Collins, Peter W., Horner, K., Morgan, N, Lowe, G, Dawood, B, Macfarlane, Kirsty   +50 more
core   +1 more source

Platelet life without TMEM163: no dense granules [PDF]

Blood, 2021
Elmina, Mammadova-Bach, Attila, Braun
openaire   +2 more sources

Dose-response relationship between agonist concentration and secretion of dense and alpha-granule-derived bioactive agents.

, 2014
The release of dense and alpha-granule components by human platelets in response to various concentrations of thrombin and collagen was assessed and compared by measuring serotonin (A), ATP (B), platelet factor 4 (PF4) (C), TGF-β1 (D), and angiopoietin-1
Stéphane Loyau (134545), Angèle Gros (613738), Amena Butt (613739), Véronique Ollivier (613736), Benoît Ho-Tin-Noé (613740), Varouna Syvannarath (613737), Martine Jandrot-Perrus (372735)   +6 more
core   +1 more source

Cytoplasmic circular dsDNA is a key constituent of stress granules

eLife
Stress granules are large cytoplasmic bodies formed in response to environmental insults by eukaryotic cells. Stress granule formation is key for post-stress recovery, and many diseases and infections are characterized by dysregulation of these ...
Natalia A Demeshkina, Adrian R Ferré-D'Amaré   +1 more
doaj   +1 more source

Localization of the small monomeric GTPases Rab3D and Rab3A in the AtT- 20 rat pituitary cell line

European Journal of Histochemistry, 2009
We investigated the cellular localization of the small GTPases Rab3D and Rab3A in AtT-20 cells treated with the drug Brefeldin A. Brefeldin A induces the redistribution of the Golgi complex into the endoplasmic reticulum and tubulation of endosomes ...
G Tabellini, G Baldini, G Baldini, R Bortul, R Bareggi, P Narducci, AM Martelli   +6 more
doaj   +1 more source

Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation

, 2017
Key PointsCompartments labeled by the vital dense granule dye mepacrine are distinct from acidic structures in platelets but not in megakaryocytes. Distinct hypoacidic mepacrine-labeled structures first appear during megakaryocyte differentiation to ...
Hayley A. Hanby, Mortimer Poncz, Danuta Jarocha, Mitchell J. Weiss, Ji-Yoon Noh, Michael S. Marks, Jialing Bao   +6 more
core   +1 more source

Local field potential modeling predicts dense activation in cerebellar granule cells clusters under LTP and LTD control. [PDF]

, 2011
Local field-potentials (LFPs) are generated by neuronal ensembles and contain information about the activity of single neurons. Here, the LFPs of the cerebellar granular layer and their changes during long-term synaptic plasticity (LTP and LTD) were ...
Diwakar Shyam, G. Naldi, SOLINAS, SERGIO MAURO GAVINO, Diwakar S, Solinas S, Naldi G, Sergio Solinas, D'Angelo E., P. Lombardo, Egidio D'Angelo, Solinas Sergio, S. Solinas, LOMBARDO, PAOLA, Naldi Giovanni, Shyam Diwakar, S. Diwakar, E. D'Angelo, Paola Lombardo, Lombardo Paola, Lombardo P, D'Angelo Egidio, Giovanni Naldi, D'ANGELO, EGIDIO UGO   +22 more
core   +2 more sources

Calcineurin controls the expression of numerous genes in cerebellar granule cells [PDF]

, 2003
The Ca(2+)/calmodulin-dependent phosphatase calcineurin plays a crucial role in gene expression in different cell types such as T-lymphocytes, cardiac myocytes, and smooth muscle cells.
Fresu, Luigia, Ashby, Dominique S, Freeman, Tom C, Genazzani, Armando A, Kramer, Dana   +4 more
core  

Cryptosporidium secreted proteins form a complex layered interface with the host cell.

PLoS Pathogens
Cryptosporidium parvum, one of the leading causes of diarrheal death in children, remodels its infection site through secreted effector proteins. Several of them accumulate at the host-parasite interface, forming a complex structure whose function and ...
Annet Puthenpurackal, Sandra Moreno Sanchez, Tifany Schaer, Léna Falconnet, Chengyue Niu, Oscar Vadas, Amandine Guérin   +6 more
doaj   +1 more source