Results 61 to 70 of about 564,000 (194)
Rab27b regulates number and secretion of platelet dense granules [PDF]
Proceedings of the National Academy of Sciences, 2007 The Rab27 GTPase subfamily consists of two closely related homologs, Rab27a and Rab27b. Rab27a has been shown previously to regulate organelle movement and regulated exocytosis in a wide variety of secretory cells. However, the role of the more restrictedly expressed Rab27b remains unclear. Here we describe the creation of
Tolmachova, T +4 more
openaire +3 more sources
Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures [PDF]
, 2012 Denervation-induced changes in excitatory synaptic strength were studied following entorhinal deafferentation of hippocampal granule cells in mature (≥3 weeks old) mouse organotypic entorhino-hippocampal slice cultures.
Roeper, Jochen +23 more
core +1 more source
The role of CaMKⅡδ in platelet activation mediated by thrombin and TRAP
Zhongguo shuxue zazhi[Objective] To investigate the role of calcium/calmodulin-dependent protein kinase Ⅱ delta (CaMKⅡδ) in platelet activation mediated by thrombin and thrombin receptor activator peptide (TRAP). [Methods] The CaMKⅡδ-specific inhibitor Hesperadin was used to
ZHAO Yafei +4 more
doaj +1 more source
Molecular Mechanisms Underlying Differential Regulation of Platelet Dense Granule Secretion by Protein Kinase C delta [PDF]
, 2010 Protein Kinase C delta (PKCδ) is expressed in platelets and activated downstream of protease-activated receptors (PAR)s and glycoprotein VI (GPVI) receptors.
Chari, Ramya
core +1 more source
Quantal Regulation and Exocytosis of Platelet Dense-Body Granules [PDF]
Biophysical Journal, 2011 This study reports how quantal size, or the quantity of chemical messengers within a storage granule, is regulated in platelet dense-body granules via dynamic adaption of granule size according to changing levels of granule contents. Mechanistic studies using carbon-fiber microelectrode fast-scan cyclic voltammetry and amperometry methods correlated ...
Ge, Shencheng +2 more
openaire +2 more sources
Nature Communications, 2020 Using a genome-wide CRISPR screen, the authors here identify Toxoplasma genes that counteract the anti-parasitic activity of interferon gamma in murine macrophages.
Yifan Wang +8 more
doaj +1 more source
Cerebellar Granule Cells: Dense, Rich and Evolving Representations [PDF]
Current Biology, 2017 For half a century it was assumed that granule cells use ultra-sparse encoding, but now in vivo calcium-imaging studies have shown that large ensembles of granule cells provide dense signals, which themselves evolve and adapt during training.
Badura, Aleksandra, De Zeeuw, Chris I
openaire +2 more sources
Cellular Distribution of NMDA Glutamate Receptor Subunit mRNAs in the Human Cerebellum
Neurobiology of Disease, 1997 We have used a quantitativein situhybridization method with human ribonucleotide probes to examine the regional and cellular distribution ofN-methyl-d-aspartate receptor (NMDAR) subunit mRNAs in the human cerebellum.
Clemens R. Scherzer +8 more
doaj +1 more source
Haematologica, 2020 In X-linked thrombocytopenia with thalassemia (XLTT; OMIM 314050), caused by the mutation p.R216Q in exon 4 of the GATA1 gene, male hemizygous patients display macrothrombocytopenia, bleeding diathesis and a b-thalassemia trait.
Daniel Bergemalm +8 more
doaj +1 more source
, 2016 Dense granule disorder is one of the most common platelet abnormalities, resulting from dense granule deficiency or secretion defect. This study was aimed to evaluate the clinical usefulness of the flow cytometric combination of mepacrine uptake/release ...
Frotscher, Birgit +15 more
core +1 more source