Results 41 to 50 of about 564,000 (194)

PCTP contributes to human platelet activation by enhancing dense granule secretion [PDF]

, 2021
PCTP (phosphatidylcholine transfer protein) was discovered recently to regulate aggregation of human platelets stimulated with PAR4 activating peptide (PAR4AP).
McKenzie, Steven, Askari, Shayan, Ma, Lin, Abraham, Shaji, Edelstein, Leonard, Kong, Xianguo   +5 more
core   +1 more source

Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma gondii Infected Host Cells

Frontiers in Immunology, 2019
Toxoplasma gondii secretes rhoptry (ROP) and dense granule (GRA) effector proteins to evade host immune clearance mediated by interferon gamma (IFN-γ), immunity-related GTPase (IRG) effectors, and CD8+ T cells.
Leah M. Rommereim, Barbara A. Fox, Kiah L. Butler, Viviana Cantillana, Gregory A. Taylor, Gregory A. Taylor, David J. Bzik   +6 more
doaj   +1 more source

Dense-granule secretion assay.

, 2013
(A) Platelets isolated from mice after 24 hours of 5-HT infusion exhibit increased dense-granule exocytosis, as indicated by increased levels of secreted 5-HT. Dense granule secretion was monitored by measuring the level of fluorescent material which was
Endrit Ziu (266466), Randy S. Haun (450795), Fusun Kilic (266477), Stephanie Byrum (450792), Charles P. Mercado (450791), Marjorie L. Beggs (117429), Vinay R. Raj (450794), Preeti Singh (450793)   +7 more
core   +1 more source

Storage pool diseases illuminate platelet dense granule biogenesis

Platelets, 2017
Platelet dense granules (DGs) are membrane bound compartments that store polyphosphate and small molecules such as ADP, ATP, Ca2+, and serotonin.
Andrea L. Ambrosio, Santiago M. Di Pietro   +1 more
doaj   +1 more source

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

mBio, 2019
Toxoplasma gondii evades host immunity to establish a chronic infection. Here, we assessed the role of parasitophorous vacuole (PV) membrane (PVM)- and intravacuolar network (IVN) membrane-localized dense granule (GRA) proteins in the development of ...
Barbara A. Fox, Rebekah B. Guevara, Leah M. Rommereim, Alejandra Falla, Valeria Bellini, Graciane Pètre, Camille Rak, Viviana Cantillana, Jean-François Dubremetz, Marie-France Cesbron-Delauw, Gregory A. Taylor, Corinne Mercier, David J. Bzik   +12 more
doaj   +1 more source

Sorting machineries: how platelet-dense granules differ from α-granules [PDF]

Bioscience Reports, 2018
Platelets respond to vascular injury via surface receptor stimulation and signaling events to trigger aggregation, procoagulant activation, and granule secretion during hemostasis, thrombosis, and vascular remodeling. Platelets contain three major types of secretory granules including dense granules (or δ-granules, DGs), α-granules (AGs), and lysosomes.
Chen, Yuanying, Yuan, Yefeng, Li, Wei
openaire   +2 more sources

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release [PDF]

Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways.
Laschober, Nicole B.
core   +3 more sources

Bidirectional GABAergic control of AP firing in newly-generated young granule cells of the adult hippocampus [PDF]

, 2015
Gamma-aminobutyric acid (GABA) is the first transmitter which provides synaptic input to newly generated neurons. In the first 2-3 weeks after mitosis, young neurons show an elevated intracellular chloride concentration due to the expression of the NKCC1
Heigele, Stefanie
core   +1 more source

Supplementation with omega‐3 or omega‐6 fatty acids attenuates platelet reactivity in postmenopausal women

Clinical and Translational Science, 2022
Postmenopausal women are at increased risk for a cardiovascular event due to platelet hyperactivity. There is evidence suggesting that ω‐3 polyunsaturated fatty acids (PUFAs) and ω‐6 PUFAs have cardioprotective effects in these women.
Adriana Yamaguchi, Livia Stanger, John Cody Freedman, Amanda Prieur, Rachel Thav, Jennyfer Tena, Theodore R. Holman, Michael Holinstat   +7 more
doaj   +1 more source

First Characterization of the Neospora caninum Dense Granule Protein GRA9

, 2017
The obligate intracellular apicomplexan parasiteis closely related to. The dense granules, which are present in all apicomplexan parasites, are important secretory organelles. Dense granule (GRA) proteins are released into the parasitophorous vacuole (PV)
Däubener, Walter, Schares, Gereon, Spekker-Bosker, Katrin, Ince, Vanessa, Leineweber, Margret, Eller, Silvia K, Hemphill, Andrew   +6 more
core   +1 more source