Results 21 to 30 of about 564,000 (194)
PKD is for dense granule secretion [PDF]
Blood, 2011 Platelet secretion of dense granule contents is important for human hemostasis, as is evident from the mucocutaneous bleeding associated with disorders of dense granule biogenesis and secretion.1 Dense granule secretion is also important for growth and stability of platelet thrombi in experimental models of thrombosis.2 Although patients with primary ...
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Participation of a transmembrane proton gradient in 5-hydroxytryptamine transport by platelet dense granules and dense-granule ghosts [PDF]
Biochemical Journal, 1981 Dense granules, the storage organelles for 5-hydroxytryptamine in blood platelets, have been isolated from porcine platelets and are shown to transport 5-hydroxytryptamine in response to a transmembrane proton gradient (delta pH). Transport in the absence of delta pH is minimal, and it is shown that a rapid increase in transport takes place as delta pH
J A, Wilkins, L, Salganicoff
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Absence of platelet phenotype in mice lacking the motor protein myosin Va.
PLoS ONE, 2013 BackgroundThe motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1 in humans and the dilute phenotype in mice, which are both characterised by pigment ...
Matthew T Harper +3 more
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mSphere, 2022 The development of molecular genetics has greatly enhanced the study of the biology and pathology associated with parasites of the phylum Apicomplexa.
Tiago W. P. Mineo +6 more
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Characterization of granule-like structures in non-endocrine cells [PDF]
, 2006 All eukaryotic cells have transport pathways to constitutively secrete proteins. Endocrine, neuroendocrine, and exocrine cells in addition have a regulated secretory pathway that serves the controlled release of hormones, neuropeptides or digestive ...
Stettler, Hansruedi
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Expansion microscopy reveals subdomains in C. elegans germ granules
Life Science Alliance, 2023 Visualising C. elegans germ granules using the super resolution technique expansion microscopy against the backdrop of proteome staining reveals granule ultrastructure.
Kin M Suen +5 more
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Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation
Haematologica, 2018 Platelet degranulation is crucial for hemostasis and may participate in inflammation. Exocytosis in platelets is mediated by SNARE proteins and should be controlled by Munc13 proteins. We found that platelets express Munc13-2 and -4. We assessed platelet
Eduardo I. Cardenas +8 more
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Heliyon, 2023 Acute ischemic stroke (AIS) is the second leading cause of death worldwide. This study aims at assessing platelet morphology, ultrastructure and function changes of platelets in acute ischemic stroke (AIS) patients by the technique of Structured ...
Bingxin Yang +10 more
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The life cycle of platelet granules [version 1; referees: 2 approved]
F1000Research, 2018 Platelet granules are unique among secretory vesicles in both their content and their life cycle. Platelets contain three major granule types—dense granules, α-granules, and lysosomes—although other granule types have been reported.
Anish Sharda, Robert Flaumenhaft
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Evaluation of human platelet granules by structured illumination laser fluorescence microscopy
Platelets, 2023 Many roles of human platelets in health and disease are linked to their ability to transport and secrete a variety of small molecules and proteins carried in dense (δ-) and α-granules.
Fred G. Pluthero, Walter H. A. Kahr
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