Results 31 to 40 of about 564,000 (194)

Toxoplasma GRA Peptide-Specific Serologic Fingerprints Discriminate Among Major Strains Causing Toxoplasmosis

Frontiers in Cellular and Infection Microbiology, 2021
The severity of toxoplasmosis depends on a combination of host and parasite factors. Among them, the Toxoplasma strain causing the infection is an important determinant of the disease outcome.
David Arranz-Solís, Cristina G. Carvalheiro, Cristina G. Carvalheiro, Elizabeth R. Zhang, Michael E. Grigg, Jeroen P. J. Saeij   +5 more
doaj   +1 more source

Defensin-rich dense granules of human neutrophils [PDF]

Blood, 1987
Defensins are a newly recognized class of small, cationic polypeptides that have in vitro microbicidal activity toward certain bacteria, fungi, and viruses. Human neutrophil granules were separated into 13 density fractions by using a high-resolution Percoll gradient centrifugation procedure, and the distribution of the three defensin polypeptides in ...
W G, Rice, T, Ganz, J M, Kinkade, M E, Selsted, R I, Lehrer, R T, Parmley   +5 more
openaire   +3 more sources

Role of Slp4 and Rab8 in dense granule release [PDF]

, 2013
Background: Platelets are highly specialized cells that regulate hemostasis and thrombosis in the vasculature. Upon activation, platelets release various granules that impact on platelets, the coagulation system, other blood cells and the vessel wall ...
Hampson, A., Smolenski, Albert P., O\u27Connor, A., O'Connor, A.   +3 more
core   +1 more source

Evaluation of immune protection against Toxoplasma gondii infection in mice induced by a multi-antigenic DNA vaccine containing TgGRA24, TgGRA25 and TgMIC6

Parasite, 2019
Toxoplasma gondii infection is prevalent in humans and animals worldwide. In this study, recombinant eukaryotic expression plasmids (pVAX-GRA24, pVAX-GRA25 and pVAX-MIC6) were constructed, and then injected into Kunming mice intramuscularly, as ...
Xu Xiao-Pei, Liu Wen-Ge, Xu Qian-Ming, Zhu Xing-Quan, Chen Jia   +4 more
doaj   +1 more source

Impact of Regulated Secretion on Antiparasitic CD8 T Cell Responses

Cell Reports, 2014
CD8 T cells play a key role in defense against the intracellular parasite Toxoplasma, but why certain CD8 responses are more potent than others is not well understood.
Harshita Satija Grover, H. Hamlet Chu, Felice D. Kelly, Soo Jung Yang, Michael L. Reese, Nicolas Blanchard, Federico Gonzalez, Shiao Wei Chan, John C. Boothroyd, Nilabh Shastri, Ellen A. Robey   +10 more
doaj   +1 more source

Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability [PDF]

, 2015
Golebiewska EM, Harper MT, Williams CM, et al. Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability. The Journal of biological chemistry.
Von Mollard, Gabriele Fischer, Golebiewska, Ewelina M., Harper, Matthew T., Williams, Christopher M, Fischer von Mollard, Gabriela, Harper, Matthew, Williams, Chris, Harper, Matthew T, Savage, Joshua S, Golebiewska, Ewelina M, Fischer von Mollard, Gabriele ; https://orcid.org/, Poole, Alastair W, Golebiewska, Ewelina, Poole, Alastair, Poole, Alastair W., Savage, Joshua S.; id_orcid, Williams, Christopher M., Goggs, Robert, Savage, JS   +18 more
core   +2 more sources

Scanning transmission X-ray microscopy study of subcellular granules in human platelets at the carbon K- and calcium L2,3-edges

Platelets, 2022
Platelets and their subcellular components (e.g., dense granules) are essential components in hemostasis. Understanding their chemical heterogeneities at the sub-micrometer scale, particularly their activation during hemostasis and production of platelet-
Jeonghee Shin, Sehee Park, Tung X. Trinh, Sook Jin Kwon, Jiwon Bae, Hangil Lee, Eugenia Valsami-Jones, Jian Wang, Jaewoo Song, Tae Hyun Yoon   +9 more
doaj   +1 more source

Neonatal Platelets: Lower G_12/13 Expression Contributes to Reduced Secretion of Dense Granules

Cells, 2022
Despite fully functional primary hemostasis, platelets of healthy neonates exhibit hypoaggregability and secretion defects, which may be adaptations to specific requirements in this developmental stage. The etiologies for reduced signal transduction vary
Axel Schlagenhauf, Sheila Bohler, Mirjam Kunze, Tanja Strini, Harald Haidl, Miriam Erlacher, Barbara Zieger   +6 more
doaj   +1 more source

Identification and characterisation of a dense granule-associated protein in Neospora caninum tachyzoites.

, 1998
Neospora caninum is an apicomplexan parasite which is morphologically and ultrastructurally very similar to Toxoplasma gondii. In order to identify molecules involved in host cell entry and subsequent modification of the parasitophorous vacuole, a ...
A. Hemphill, Gottstein, Bruno, Jenkins, M, Sonda, S, N. Gajendran, S. Sonda, Hemphill, Andrew, Gajendran, N, Fuchs, N, B. Gottstein, M. Jenkins, N. Fuchs, Hentrich, B, B. Hentrich, Gottstein B, Sonda S, Hemphill A, Fuchs N, Gajendran N, Hentrich B, Jenkins M   +20 more
core   +2 more sources

Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures

Acta Neuropathologica Communications, 2020
Chronic epilepsy has been associated with hippocampal abnormalities like neuronal loss, gliosis and granule cell dispersion. The granule cell layer of a normal human hippocampal dentate gyrus is traditionally regarded as a compact neuron-dense layer ...
Achira Roy, Kathleen J. Millen, Raj P. Kapur   +2 more
doaj   +1 more source