Results 11 to 20 of about 564,000 (194)

Thiazole orange: a complement to established methods for diagnosing inherited dense granule defects

Platelets
Inherited delta storage pool deficiencies are likely underdiagnosed due to limitations in available diagnostic tools. Achieving accurate diagnosis is thus challenging for clinical laboratories highlighting the need for improved methods.
Myriam Martin, Karin Strandberg, Eva Zetterberg, Eva Norström   +3 more
doaj   +2 more sources

Comparative study of platelet dense granule constituents

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1982
Cat, cattle, dog, horse, human, mink, pig, and rabbit platelets were separated from plasma by gel filtration. The gel-filtered platelets (GFP) were treated with thrombin to induce maximal granule secretion and the potential dense granule constituents ATP, ADP, serotonin (5-HT), Ca2+, and Mg2+ were measured in GFP and in the control and thrombin-treated
K M, Meyers, H, Holmsen, C L, Seachord
openaire   +3 more sources

Platelet dense-granule centralization and the persistence of ADP secretion

American Journal of Physiology-Heart and Circulatory Physiology, 1996
After activation of a human platelet, its adenosine diphosphate (ADP)-containing dense granules are moved toward the platelet's center and release their ADP into the channels of the open canalicular system (OCS). Mathematical modeling is used to investigate a possible role of this centralization in prolonging the duration of ADP secretion compared ...
A L, Fogelson, N T, Wang
openaire   +3 more sources

Timing of dense granule biogenesis in asexual malaria parasites. [PDF]

Microbiology (Reading), 2023
ABSTRACT Malaria is an important infectious disease that continues to claim hundreds of thousands of lives annually. The disease is caused by infection of host erythrocytes by apicomplexan parasites of the genus Plasmodium .
Vallintine T, van Ooij C.
europepmc   +3 more sources

DGPD: a knowledge database of dense granule proteins of the Apicomplexa. [PDF]

Database (Oxford), 2022
Abstract Apicomplexan parasites cause severe diseases in human and livestock. Dense granule proteins (GRAs), specific to the Apicomplexa, participate in the maintenance of intracellular parasitism of host cells. GRAs have better immunogenicity and they can be emerged as important players in vaccine development.
Hu H, Lu Z, Feng H, Chen G, Wang Y, Yang C, Yue Z.   +6 more
europepmc   +4 more sources

First Characterization of the Neospora caninum Dense Granule Protein GRA9. [PDF]

Biomed Res Int, 2017
The obligate intracellular apicomplexan parasiteNeospora caninum (N. caninum)is closely related toToxoplasma gondii (T. gondii). The dense granules, which are present in all apicomplexan parasites, are important secretory organelles.
Leineweber M, Spekker-Bosker K, Ince V, Schares G, Hemphill A, Eller SK, Däubener W.   +6 more
europepmc   +3 more sources

Transfer of a dense granule protein of Plasmodium falciparum to the membrane of ring stages and isolation of dense granules [PDF]

Infection and Immunity, 1992
A 14-kDa protein was localized to the dense granules of Plasmodium falciparum by immunoelectron microscopy with monoclonal antibody 1H1. The protein was present in dense granules in late-stage schizonts and free merozoites. After invasion, the protein was localized exclusively on the membrane of the newly invaded ring.
W, Trager, C, Rozario, H, Shio, J, Williams, M E, Perkins   +4 more
openaire   +2 more sources

The complementary roles of VAMP-2, -3, and -7 in platelet secretion and function

Platelets, 2023
Platelet secretion requires Soluble N-ethylmaleimide Sensitive Attachment Protein Receptors (SNAREs). Vesicle SNAREs/Vesicle-Associated Membrane Proteins (v-SNAREs/VAMPs) on granules and t-SNAREs in plasma membranes mediate granule release. Platelet VAMP
Smita Joshi, Kanakanagavalli Shravani Prakhya, Alexis N. Smith, Harry Chanzu, Ming Zhang, Sidney W. Whiteheart   +5 more
doaj   +1 more source

Task-dependent optimal representations for cerebellar learning

eLife, 2023
The cerebellar granule cell layer has inspired numerous theoretical models of neural representations that support learned behaviors, beginning with the work of Marr and Albus.
Marjorie Xie, Samuel P Muscinelli, Kameron Decker Harris, Ashok Litwin-Kumar   +3 more
doaj   +1 more source

Quantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency [PDF]

Blood, 1992
Abstract An antigen-capture sandwich enzyme-linked immunosorbent assay (ELISA) was developed for a novel protein granulophysin, a constituent of the platelet dense granule (DG) membrane and used to characterize patients with dense granule storage pool deficiency (delta-SPD).
A, Shalev, G, Michaud, S J, Israels, A, McNicol, S, Singhroy, E M, McMillan, J G, White, C J, Witkop, W L, Nichols, A H, Greenberg   +9 more
openaire   +2 more sources