Phosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and maturation in Toxoplasma gondii. [PDF]
PLoS PathogensPhosphoinositide metabolism defines the foundation of a major signaling pathway that is conserved throughout the eukaryotic kingdom. Although the 4-OH phosphorylated phosphoinositides phosphatidylinositol-4-phosphate (PtdIns4P) and phosphatidylinositol-4,
Angela Arabiotorre +3 more
doaj +2 more sources
Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion [PDF]
Life, 2021 The host cell invasion process of apicomplexan parasites like Toxoplasma gondii is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family.
Daniel N. A. Tagoe +5 more
doaj +2 more sources
3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets [PDF]
Research and Practice in Thrombosis and Haemostasis, 2020 Background State‐of‐the‐art 3‐dimensional (3D) electron microscopy approaches provide a new standard for the visualization of human platelet ultrastructure.
Irina D. Pokrovskaya +8 more
doaj +2 more sources
Study of dense granule proteins in Eimeria spp. identifies a limited repertoire with potential as vaccine candidates [PDF]
Frontiers in ImmunologyEimeria species are obligate intracellular parasites that usually replicate in intestinal cells and can cause the disease coccidiosis. Coccidiosis of livestock and poultry incurs significant production losses and compromises animal welfare, with the ...
Gonzalo Sanchez-Arsuaga +3 more
doaj +2 more sources
Platelet dense granule defect: experience in the French population [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Platelet dense granule defect (DGD) is a frequent inherited disorder that is underdiagnosed due to its complexity and poor standardization of diagnostic tools.
Delphine Borgel +19 more
doaj +2 more sources
Molecular interactions of Toxoplasma gondii dense granule 23 (GRA23) with host proteins PEX3 and TRAP1 [PDF]
Frontiers in Veterinary ScienceBackgroundToxoplasma gondii, an obligate intracellular protozoan, utilizes dense granule proteins to modulate host cell processes. Dense granule protein 23 (GRA23) facilitates molecular trafficking between the parasitophorous vacuole and host cell cyto ...
Xuewei Fan +9 more
doaj +2 more sources
Frontiers in Cardiovascular Medicine, 2022 BackgroundVaccine-induced thrombotic thrombocytopenia (VITT) post SARS-CoV-2 vaccination is characterized by thrombocytopenia and severe thrombosis. Platelet function during patient recovery in the medium-/long-term has not been investigated fully. Here,
Shane P. Comer +34 more
doaj +1 more source
Deep learning-based multi-model approach on electron microscopy image of renal biopsy classification
BMC Nephrology, 2023 Background Electron microscopy is important in the diagnosis of renal disease. For immune-mediated renal disease diagnosis, whether the electron-dense granule is present in the electron microscope image is of vital importance.
Jingyuan Zhang, Aihua Zhang
doaj +1 more source
Microbiology Spectrum, 2021 The formation of dense, well-settling methanogenic granules is essential for the operation of high-rate, up-flow anaerobic bioreactors used for wastewater treatment.
Simon Mills +4 more
doaj +1 more source
The strategies of NLRP3 inflammasome to combat Toxoplasma gondii
Frontiers in Immunology, 2022 Infection with the protozoan parasite Toxoplasma gondii (T. gondii) results in the activation of nucleotide-binding domain leucine-rich repeat containing receptors (NLRs), which in turn leads to inflammasome assembly and the subsequent activation of ...
Chanjin Yoon +4 more
doaj +1 more source