Results 71 to 80 of about 564,000 (194)

Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3

Cells, 2019
Typical Rho GTPases, such as Rac1, Cdc42, and RhoA, act as molecular switches regulating various aspects of platelet cytoskeleton reorganization. The loss of these enzymes results in reduced platelet functionality.
Martin Berger, David R. J. Riley, Julia Lutz, Jawad S. Khalil, Ahmed Aburima, Khalid M. Naseem, Francisco Rivero   +6 more
doaj   +1 more source

Biogenesis of Dense-Core Secretory Granules

, 2009
Dense core granules (DCGs) are vesicular organelles derived from outbound traffic through the eukaryotic secretory pathway. As DCGs are formed, the secretory pathway can also give rise to other types of vesicles, such as those bound for endosomes, lysosomes, and the cell surface.
Bowman, Grant R., Cowan, Andrew T., Turkewitz, Aaron P.   +2 more
openaire   +1 more source

Raw data for Cryptosporidium parvum dense granule protein DG9 interacts with DG10 at the parasite-host interface

Raw WB images, electrophoresis gels, primer sequences and numerical data supporting the conclusions in Cryptosporidium parvum dense granule protein DG9 interacts with DG10 at the parasite-host ...
xiao, qianqian
core   +1 more source

Rab3D is critical for secretory granule maturation in PC12 cells. [PDF]

, 2013
Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.
Sharon A. Tooze (391543), Kögel Tanja, Copier, J., Hodneland, E, Gerdes, HH, Gerdes Hans-Hermann, Tooze, S. A., Tooze Sharon A., Copier, J, Rüdiger Rudolf (151449), Tanja Kögel, Romano Regazzi, Rudolf Rüdiger, Copier John, Gerdes, H. H., Tooze, SA, Tanja Kögel (391540), Kögel, T., Hans-Hermann Gerdes, Kögel, T, Hodneland Erlend, John Copier, Tooze, S.A., Rudolf, R., Regazzi Romano, Regazzi, R, Erlend Hodneland, Gerdes, H.H., Erlend Hodneland (391541), Regazzi, R., Sharon A Tooze, Hodneland, E., John Copier (391542), Rudolf, R, Romano Regazzi (210061), Rüdiger Rudolf, Hans-Hermann Gerdes (127873), Rudolf, Rüdiger, Kögel, Tanja, Regazzi, Romano, Hodneland, Erlend, Copier, John, Gerdes, Hans-Hermann, Tooze, Sharon A.   +43 more
core   +1 more source

A flow cytometric assay for the study of dense granule storage and release in human platelets

, 1999
The clinical manifestations of platelet dense (δ) granule defects are easy bruising, as well as epistaxis and bleeding after delivery, tooth extractions and surgical procedures.
Fagerberg, I., Fagerberg, I.,, Lindahl, Tomas,, Ramström, A Sofia,, Ramström, A Sofia, Lindahl, Tomas   +5 more
core   +1 more source

Dense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in vivo

, 2017
Dense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in ...
Jin Yeul Ma (21723838), Byeong-Hoon Lee (3430961), Hyun-Cheol Lee (2953611), Jong-Soo Lee (194708), Tae-Hwan Kim (548668), WA Gayan Chathuranga (22051928), Kiramage Chathuranga (7245233), Thilina UB Herath (22051973), Chul-Su Yang (81811), Prasanna Weeratunga (548670), Eun-Seo Lee (11787026), Jae-Hoon Kim (442860)   +11 more
core  

Wet granulation in laboratory scale high shear mixers: Effect of binder properties [PDF]

, 2011
The effect of binder properties on torque curves, granule growth kinetics, wet mass consistency and dry granule strength has been investigated in this study.
Hemati, Mehrdji, M. Hemati, Oulahna, Driss, T.M. Chitu, D. Oulahna, Chitu, Toma Mihai   +5 more
core   +1 more source

The cellular basis of platelet secretion: Emerging structure/function relationships

Platelets, 2017
Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site ...
Shilpi Yadav, Brian Storrie
doaj   +1 more source

Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

, 2021
BackgroundSerglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.ObjectiveTo understand how SRGN affects platelet granule packaging, cargo release, and extra-platelet ...
Lykins, Joshua,, Storrie, Brian,, Wigna-Kumar, Subershan,, Wood, Jeremy P.,, Whiteheart, Sidney W.,, Joshi, Smita,, Chanzu, Harry,, Pejler, Gunnar,, Pokrovskaya, Irina,   +8 more
core   +1 more source

Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes

Cell Reports
Summary: Stress granules are a conserved response of eukaryotic cells to environmental insults. These cytoplasmic ribonucleoprotein condensates have hitherto been primarily studied by microscopy, which showed previously that they comprise dense ∼200 nm ...
Natalia A. Demeshkina, Adrian R. Ferré-D’Amaré   +1 more
doaj   +1 more source