Results 71 to 80 of about 55,761 (291)
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Multi-Frequency VLBA Polarimetry and the Twin-Jet Quasar 0850+581
Galaxies, 2017 We present the first multi-frequency VLBA study of the quasar 0850+581 which appears to have a two-sided relativistic jet. Apparent velocity in the approaching jet changes from 3.4c to 7c with the separation from the core. The jet-to-counter-jet ratio of
Evgeniya Kravchenko, Yuri Y. Kovalev
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Cost evaluation of different medium solids for air dense medium fluidized bed coal separation
, 2017 Masters dissertation submitted in fulfilment of the requirements for the degree of Master of Science in Engineering to Faculty of Engineering and the Built Environment, University of the Witwatersrand, Johannesburg, South Africa, 2017Dense medium ...
Chagwedera, Kundayi Marshall
core +1 more source
An overview of coarse particle beneficiation of lithium ores
Scientific ReportsThe increasing demand for lithium-ion batteries particularly for electric vehicles underscores the importance of improving the sustainability of lithium mining operations. The depletion of high-grade lithium ore deposits has necessitated the upgrading of
Philipa A. Opoku +3 more
doaj +1 more source
CFD based study of dense medium drum separation processes
, 2017 Dense Medium Drum (DMD) separation is applied particularly in the coal and recycling industries. Characteristic of the process is a separation based on density, driven by the buoyancy and gravitational forces acting on an object moving in a free surface ...
Vanierschot, Maarten +2 more
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source