Results 121 to 130 of about 84,432 (239)

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).
Emanuela Pesce   +25 more
wiley   +1 more source

Endothelial‐Mesenchymal Transition in Tumor Microenvironment Promotes Neuroendocrine Differentiation of Prostate Cancer

open access: yesCancer Science, EarlyView.
Endothelial‐mesenchymal transition (EndoMT) contributes to neuroendocrine differentiation (NED) in prostate cancer. Using in vitro co‐culture models, we show that EndoMTed endothelial cells promote NED in prostate cancer cells via GM‐CSF signaling. These findings reveal a previously unrecognized paracrine mechanism by which the tumor microenvironment ...
Takumi Kageyama   +11 more
wiley   +1 more source

Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly

open access: yesCancer Science, EarlyView.
Our findings demonstrate that AurA facilitates cell cycle reentry by promoting primary cilia disassembly. Utilizing an inducible degron system, we showed that AurA depletion delays the G0/G1 transition, a defect rescued by forced deciliation. These results underscore AurA's role beyond mitosis and reinforce its potential as a therapeutic target in ...
Atsushi Kohso   +6 more
wiley   +1 more source

Osteoporosis in Men, Risk Factors and Total Body Bone Densitometry Results [PDF]

open access: bronze, 1994
S. Moore   +7 more
openalex   +1 more source

PIK3C2A‐Related Clinical Phenotype and Cellular Charaterization Linked to Functional SHH Primary Cilia Defect

open access: yesClinical Genetics, EarlyView.
Trio exome sequencing allowed the identification of two novel compound heterozygous variants in PIK3C2A, defining the fifth family presenting a PIK3C2A‐related syndrome characterized by pulverulent cataracts and deafness. Functional testing revealed impaired PI metabolism and primary dysfunction phenotype.
Adella Karam   +9 more
wiley   +1 more source

Quantitative determination of ergothioneine in plasma and tissues by TLC-densitometry.

open access: bronze, 1980
Ikue Kaneko   +7 more
openalex   +2 more sources

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