Results 51 to 60 of about 252,175 (379)

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]

, 2014
Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed, Liu, Zhiping, Lupfer, Christopher R, Stokes, Kate L, Vogel, Peter   +6 more
core   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Effect of rheumatoid arthritis activity on corneal densitometry, curvature, thickness, and lens densitometry

Journal of the Egyptian Ophthalmological Society
Purpose To evaluate the effect of rheumatoid arthritis (RA) activity on the corneal densitometry, corneal curvature (CC), central corneal thickness (CCT), and lens densitometry and compare these parameters with healthy control patients.
Mohamed S.E. Mahmoud, Ahmed Hamed, Mohamed E. Abdullah, Mohamed T. Moustafa, Doaa ElFadaly   +4 more
doaj   +1 more source

Weak lensing mass reconstructions of the ESO Distant Cluster Survey

, 2005
We present weak lensing mass reconstructions for the 20 high-redshift clusters i n the ESO Distant Cluster Survey. The weak lensing analysis was performed on deep, 3-color optical images taken with VLT/FORS2, using a composite galaxy catalog with ...
A. Aragón-Salamanca, B. Milvang-Jensen, B. Poggianti, Bertin, Bolzonella, Bruzual, C. Halliday, Clowe, Clowe, Clowe, Clowe, Clowe, D. Clowe, D. Zaritsky, Dahle, Eke, Evrard, Fahlman, Fontana, Frenk, G. De Lucia, G. Rudnick, Gioia, Gonzalez, Halliday, Henry, Henry, Henry, Kaiser, Kneib, L. Simard, Luppino, M. Bremer, Navarro, Oukbir, P. Jablonka, P. Schneider, R. Pelló, R. Saglia, Rudnick, Rudnick, S. White, Schlegel, Schneider, Schneider, Seitz, van den Bosch, van Waerbeke, Wechsler, White   +49 more
core   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Calcium signalling links MYC to NUAK1 [PDF]

, 2018
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A,, Knight, J.R., Monteverde, T., Murphy, D.J., Sansom, O.J., Tait-Mulder, J.   +5 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Use of TLC-Densitometric Method for Determination of Valproic Acid in Capsules

Molecules, 2022
Determination of valproic acid in the drug was carried out on the aluminum silica gel 60F254 plates and using acetone–water–chloroform–ethanol–ammonia at a volume ratio of 30:1:8:5:11 as the mobile phase, respectively.
Wioletta Parys, Alina Pyka-Pająk
doaj   +1 more source

Weak Lensing by High-Redshift Clusters of Galaxies - I: Cluster Mass Reconstruction

, 2000
We present the results of a weak lensing survey of six high-redshift (z > 0.5), X-ray selected clusters of galaxies. We have obtained ultra-deep R-band images of each cluster with the Keck Telescope, and have measured a weak lensing signal from each ...
Bartelmann M., D. Clowe, Eke V. R., Ellis R. S., Fischer P., G. A. Luppino, I. M. Gioia, Kaiser N., N. Kaiser, Neumann D. M., Reblinsky K., Schneider P., Seitz C., Smail I.   +13 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source