Results 81 to 90 of about 1,148,937 (245)

Dental follicle stem cells rescue the regenerative capacity of inflamed rat dental pulp through a paracrine pathway

Stem Cell Research & Therapy, 2020
Background Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment method, but its application is ...
Hong Hong, Xiaochuan Chen, Kun Li, Nan Wang, Mengjie Li, Bo Yang, Xiaoqi Yu, Xi Wei   +7 more
doaj   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell Differentiation Into Odontoblast-Like Cells and Endothelial Cells: A Potential Cell Source for Dental Pulp Tissue Engineering

Frontiers in Physiology, 2020
ObjectivesDental pulp regeneration is considered an ideal approach for treating dental pulp disease. Because pulp is composed of various cells, determining the proper seed cells is critical.
Shuang Zhang, Shuang Zhang, Weiwei Zhang, Weiwei Zhang, Yanping Li, Yanping Li, Liping Ren, Haotian Deng, Haotian Deng, Xiaowei Yin, Xiaowei Yin, Xu Gao, Shuang Pan, Shuang Pan, Yumei Niu, Yumei Niu   +15 more
doaj   +1 more source

Mechanical memory in aging: From adaptive sensing to pathological entrenchment

Interdisciplinary Medicine, EarlyView.
Mechanical memory in aging operates through four temporal tiers, from cytoskeletal remodeling to metabolic reprogramming. Aging disrupts this cascade through three distinct decoupling patterns: sensor degradation, conduction blockade, and execution failure, leading to irreversible pathological entrenchment across multiple organ systems.
Mingyang Huang, Xiaoyu Ma, Ruiqi Gao, Qichen Miao, Guoqing Wang, Ziyuan Liu, Kun Wang, Ming Luo   +7 more
wiley   +1 more source

Evaluating the efficacy of human dental pulp stem cells and scaffold combination for bone regeneration in animal models: a systematic review and meta-analysis

Stem Cell Research & Therapy, 2023
Introduction Human adult dental pulp stem cells (hDPSC) and stem cells from human exfoliated deciduous teeth (SHED) hold promise in bone regeneration for their easy accessibility, high proliferation rate, self-renewal and osteogenic differentiation ...
Amin Namjoynik, Md Asiful Islam, Mohammad Islam   +2 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Quantitative collagen and proteoglycan imaging reveal organic layering, gradients and regional texture in young mature dental cementum

VIEW, EarlyView.
Cementum, the mineralized tissue covering all mammalian tooth roots, helps maintain tooth stability, but its internal organization is still poorly understood. In this study, we combine quantitative histologial methods to map the regional distributions of collagen fibers and proteoglycan‐rich matrix layers in porcine cementum.
Jie Zhen, Yuyang Mao, Hamza Elfarraj, Paul Zaslansky   +3 more
wiley   +1 more source

The Application of Pulp Tissue Derived-Exosomes in Pulp Regeneration: A Novel Cell-Homing Approach

International Journal of Nanomedicine, 2022
Yan Chen,1– 5,* Yue Ma,1– 5,* Xueting Yang,1– 5 Jinlong Chen,1– 5 Bo Yang,1– 5 Weidong Tian1– 5 1Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China Hospital of Stomatology, Sichuan University, Chengdu ...
Chen Y, Ma Y, Yang X, Chen J, Yang B, Tian W   +5 more
doaj  

Expression of high mobility group box 1 in inflamed dental pulp and its chemotactic effect on dental pulp cells

, 2014
High mobility group box 1 protein (HMGB1) is a chromatin protein which can be released extracellularly, eliciting a pro-inflammatory response and promoting tissue repair process.
Jiang, Hongwei, Zhang, Xufang, Huang, Yihua, Fan, Chen, Ling, Junqi, Gong, Qimei   +5 more
core   +1 more source

What Outcomes Matter in Vital Pulp Therapy? Current Concepts and Challenges

Australian Dental Journal, EarlyView.
ABSTRACT Vital pulp therapy (VPT) has re‐emerged as a practical and biologically sound alternative for managing deep caries and carious pulp exposures. Although its clinical use is now widespread, the outcomes used to judge the success of VPT remain inconsistent and often difficult to compare across studies.
Philip Yuan‐Ho Chien, Sepanta Hosseinpour, Richard Huynh, Graham Xuanwei Wong, Christine Inge Peters, Ove Andreas Peters   +5 more
wiley   +1 more source

Dental pulp stem cells conditioned medium-functionalized microspheres for endodontic regeneration

Frontiers in Cell and Developmental Biology
IntroductionDental pulp disease represents a prevalent oral pathology with limited success in functional regeneration of the pulp-dentin complex.
Jing Gao, Jing Gao, Yuhan Wang, Yuhan Wang, Tongxing Zhang, Jiafei Qu, Jiafei Qu, Qian Liu, Yao Chen, Yao Chen, Baoshan Xu, Jing Shen, Jing Shen   +12 more
doaj   +1 more source