Results 71 to 80 of about 17,547 (221)

Mechanical memory in aging: From adaptive sensing to pathological entrenchment

Interdisciplinary Medicine, EarlyView.
Mechanical memory in aging operates through four temporal tiers, from cytoskeletal remodeling to metabolic reprogramming. Aging disrupts this cascade through three distinct decoupling patterns: sensor degradation, conduction blockade, and execution failure, leading to irreversible pathological entrenchment across multiple organ systems.
Mingyang Huang, Xiaoyu Ma, Ruiqi Gao, Qichen Miao, Guoqing Wang, Ziyuan Liu, Kun Wang, Ming Luo   +7 more
wiley   +1 more source

Comparative evaluation of the isolation and quantification of stem cells derived from dental pulp and periodontal ligament of a permanent tooth and to assess their viability and proliferation on a platelet-rich fibrin scaffold

Journal of Indian Society of Periodontology, 2017
Background: The present study aims to comparatively evaluate the isolation and quantification of stem cells derived from dental pulp and periodontal ligament of a permanent tooth and to assess their viability and proliferation on a platelet-rich fibrin ...
Rohit Khurana, Praveen Bhasker Kudva, Syed Yawer Husain   +2 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

What Outcomes Matter in Vital Pulp Therapy? Current Concepts and Challenges

Australian Dental Journal, EarlyView.
ABSTRACT Vital pulp therapy (VPT) has re‐emerged as a practical and biologically sound alternative for managing deep caries and carious pulp exposures. Although its clinical use is now widespread, the outcomes used to judge the success of VPT remain inconsistent and often difficult to compare across studies.
Philip Yuan‐Ho Chien, Sepanta Hosseinpour, Richard Huynh, Graham Xuanwei Wong, Christine Inge Peters, Ove Andreas Peters   +5 more
wiley   +1 more source

Biocompatibility With Osteogenic Potential of Premixed Bioceramic Cements for Use in Apical Surgery

Australian Endodontic Journal, EarlyView.
ABSTRACT This study investigated the biocompatibility and osteogenic potential of premixed bioceramic cements (PBCs)—CeraPutty, EndoCEM MTA Premixed, Well‐Root PT, and One‐Fil PT Injectable—as alternatives to mineral trioxide aggregate for retrograde filling in endodontic microsurgery.
Yesol Kim, Jae‐Hoon Kim, Unni Krishnan, Hyeon‐Cheol Kim, Minju Song, Sang Won Kwak   +5 more
wiley   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

CGRP-mediated neuro-vascular-pulp cell crosstalk is essential for dental pulp repair

Frontiers in Cell and Developmental Biology
IntroductionThe repair of dental pulp injury is the cornerstone of vital pulp therapy. Traditional research has predominantly focused on the roles of immune cells, vascular endothelial cells, and dental pulp stem cells, often overlooking the active ...
Zixin Wu, Junyang Chen, Yiming Zhao, Zhenjuan Zhou, Rui Lin, Wei Liu, Wei Liu   +6 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

Angiogenic regulation of dental pulp stem cells

Frontiers in Dental Medicine
Tissue regeneration relies on the ingrowth of blood vessels from the host for the survival and functionalization of regenerated tissues. Any holdup in this process can threaten the viability of the transplanted progenitor cells, which in turn can hinder effective tissue regeneration.
Dissanayaka, Waruna Lakmal, Nowwarote, Nunthawan, Srisuwan, Tanida, Hiran-Us, Sirawut, Kornsuthisopon, Chatvadee, Zhu, Xiaofei, Osathanon, Thanaphum   +6 more
openaire   +2 more sources