OPTN interacts with NRF2 to facilitate the AKT/DRP1‐mediated regulation of mitochondrial fission in the cytoplasm of SCAPs, promoting tooth root mineralisation. Additionally, OPTN maintains NRF2's nuclear translocation, enhancing the transcriptional regulation of downstream BCL2, ultimately leading to the inhibition apoptosis in SCAPs and regulate ...
Haojie Liu+9 more
wiley +1 more source
Telomere Attrition Occurs during Ex Vivo Expansion of Human Dental Pulp Stem Cells [PDF]
We provide a detailed characteristic of stem cells isolated and expanded from the human dental pulp. Dental pulp stem cells express mesenchymal cell markers STRO-1, vimentin, CD29, CD44, CD73, CD90, CD166, and stem cell markers Sox2, nestin, and ...
Benjamin Visek+9 more
core +3 more sources
Dental pulp stem cells express proteins involved in the local invasiveness of odontogenic myxoma
Little is known about the histogenesis of the odontogenic myxoma (OM). Dental pulp stem cells could be candidate precursors of OM because both OM and the dental pulp share the same embryological origin: the dental papilla. For the purpose of comparing OM
Sueli Patricia Harumi Miyagi+3 more
doaj +1 more source
Electroporation for Transfection and Differentiation of Dental Pulp Stem Cells
Target gene delivery is needed to induce cellular differentiation or a specific therapeutic effect. Electroporation is a relatively safe and simple technique to deliver nucleic acids to the cell that acts by rendering cells transiently permeable using short periods of high voltage. In stem cell research, human dental pulp stem cells (hDPSCS) are highly
Bakr M. Rabie, Ahmed Rizk
openaire +3 more sources
Organoids in Haematologic Research: Advances and Future Directions
This review focuses on the advancements in organoid technology and its transformative role in haematological research, particularly in the modelling of haematopoietic tissues, blood diseases and drug development. It also offers an outlook on the future prospects of organoids in personalised medicine and the study of disease mechanisms.
Liangzheng Chang+4 more
wiley +1 more source
Mystery Inside the Tooth: The Dental Pulp Stem Cells
Stem cells are distinguished by their ability to differentiate into different types of cells in the body and to self-replicate. During the recent years, stem cells have been used extensively in the field of medicine for the repair and regeneration of defective tissues and organs.
Gopalakrishnan T+3 more
openaire +4 more sources
Sirt3 Rescues Porphyromonas gingivalis‐Impaired Cementogenesis via SOD2 Deacetylation
Sirt3 deacetylated SOD2 via K68 to orchestrate P.g.‐impaired cementogenesis. Reestablishment of the Sirt3/SOD2 axis by honokiol reduced SOD2 acetylation and facilitated cementogenesis. ABSTRACT The keystone pathogen Porphyromonas gingivalis (P.g.) is responsible for cementum resorption in periodontitis; however, the mechanism involved in it remains ...
Xin Huang+6 more
wiley +1 more source
Graphene-based nanomaterials for tissue engineering in the dental field [PDF]
The world of dentistry is approaching graphene-based nanomaterials as substitutes for tissue engineering. Apart from its exceptional mechanical strength, electrical conductivity and thermal stability, graphene and its derivatives can be functionalized ...
Antoniac, I+9 more
core +1 more source
A modified efficient method for dental pulp stem cell isolation
Background: Dental pulp stem cells can be used in regenerative endodontic therapy. The aim of this study was to introduce an efficient method for dental pulp stem cells isolation.
Maryam Raoof+6 more
doaj
Optical signal recording of cellular activity in optogenetic stimulation of human pulp dental cells using a twin-core fiber-based Mach-Zehnder interferometer biosensor [PDF]
This paper introduces an innovative two-core fiber (TCF) optic sensor employing a Mach-Zehnder interferometer (MZI) to monitor the optogenetic response of light-sensitive human dental pulp stem cells (hDPSCs). The in-fiber MZI, formed using a segment of TCF optic, detects refractive index (RI) changes in the surrounding medium.
arxiv