Results 121 to 130 of about 27,818 (210)

DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1

International Journal of Medical Microbiology
Dengue virus (DENV) is one of the major arboviruses that pose a serious threat to global human health. However, there is currently no specific antiviral drug available for the treatment of DENV infection. DDX17, a member of the DExD/H-box helicase family, has been implicated in the replication processes of various viruses. Our research group discovered
Peijun Han, Wei Ye, Hongwei Ma, Yangchao Dong, Xin Lv, He Liu, Linfeng Cheng, Liang Zhang, Sumin Li, Yingfeng Lei, Fanglin Zhang   +10 more
openaire   +3 more sources

Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020

Viruses, 2020
Dengue virus (DENV) serotype-2 was detected in the South Pacific region in 2014 for the first time in 15 years. In 2016–2020, DENV-2 re-emerged in French Polynesia, Vanuatu, Wallis and Futuna, and New Caledonia, co-circulating with and later replacing ...
Catherine Inizan, Olivia O’Connor, George Worwor, Talica Cabemaiwai, Jean-Claude Grignon, Dominique Girault, Marine Minier, Matthieu Prot, Valentine Ballan, George Junior Pakoa, Jean-Paul Grangeon, Philippe Guyant, Christelle Lepers, Daniel Faktaufon, Aalisha Sahukhan, Onofre Edwin Merilles, Ann-Claire Gourinat, Etienne Simon-Lorière, Myrielle Dupont-Rouzeyrol   +18 more
doaj   +1 more source

Identifying the strains of dengue circulating in the western province of Sri Lanka during 2019-2022.

PLOS Global Public Health
A study conducted from July 2019 to May 2022 at several hospitals in the Western Province, Sri Lanka, focused on dengue virus strains during the COVID-19 pandemic. Among 417 febrile patients, 47% were PCR-positive for dengue.
Harshi Abeygoonawardena, Kanchana Dassanayake, Jayani Kariyawasam, Teshan Chathuranga, Tharmini Sundralingam, Hansani Gunasekara, Sathyani Wevita, Gayani Premawansa, Sunil Premawansa, Ananda Wijewickrama, Namal Wijesinghe, Varuna Navaratne, Daniela Weiskopf, Alessandro Sette, Chandanamali Punchihewa, Aruna Dharshan De Silva   +15 more
doaj   +1 more source

Spatiotemporal characterizations of dengue virus in mainland China: insights into the whole genome from 1978 to 2011.

PLoS ONE, 2014
Temporal-Spatial of dengue virus (DENV) analyses have been performed in previous epidemiological studies in mainland China, but few studies have examined the whole genome of the DENV.
Hao Zhang, Yanru Zhang, Rifat Hamoudi, Guiyun Yan, Xiaoguang Chen, Yuanping Zhou   +5 more
doaj   +1 more source

Styrylpyrone Derivative (SPD), a Novel DENV-2 NS3, NS5 and prM Inhibitor; Inhibited RNA Replication, Protein Transcription and Production of DENV-2 Progeny Particles

Sains Malaysiana
In the last few decades, dengue has become much more commonplace worldwide, and it is quickly spreading to other countries. As of right now, supportive care is the only available treatment for dengue infection as there are no approved antivirals. Although a DENV vaccine has recently been used in some countries, its indication is limited due to risk of ...
Noor Zarina Abd Wahab, Nazlina Ibrahim
openaire   +1 more source

A NEW COPPER (II)-IMIDAZOLE DERIVATIVE EFFECTIVELY INHIBITS REPLICATION OF DENV-2 IN VERO CELL

African Journal of Infectious Diseases, 2018
Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important.
Teguh Hari Sucipto, .-, Siti Churrotin, .-, Harsasi Setyawati, .-, Fahimah Martak, .-, Kris Cahyo Mulyatno, .-, Ilham Harlan Amarullah, .-, Tomohiro Kotaki, .-, Masanori Kameoka, .-, Subagyo Yotopranoto, .-, Soegeng Soegijanto, .-   +9 more
openaire   +3 more sources

The Dengue ED3 Dot Assay, a Novel Serological Test for the Detection of Denguevirus Type-Specific Antibodies and Its Application in a Retrospective Seroprevalence Study

Viruses, 2019
There are four distinct antigenic serotypes of dengue viruses (DENV-1-4). Sequential infections with different serotypes lead to cross-reactive but also serotype-specific neutralizing antibody responses.
Heidi Auerswald, Leonard Klepsch, Sebastian Schreiber, Janne Hülsemann, Kati Franzke, Simone Kann, Bunthin Y, Veasna Duong, Philippe Buchy, Michael Schreiber   +9 more
doaj   +1 more source

Emergence of new genotypes and lineages of dengue viruses during the 2012–15 epidemics in southern India

International Journal of Infectious Diseases, 2019
Objectives: To genotypically characterize dengue virus (DENV) isolates among dengue-infected children from 2012–13/2014–15 outbreaks in southern India.
Syed Fazil Ahamed, Vivek Rosario, Carl Britto, Mary Dias, Kaustuv Nayak, Anmol Chandele, Murali-Krishna Kaja, Anita Shet   +7 more
doaj   +1 more source

Computational identification of Vernonia cinerea-derived phytochemicals as potential inhibitors of nonstructural protein 1 (NSP1) in dengue virus serotype-2

Frontiers in Pharmacology
BackgroundDengue virus (DENV) infection, spread by Aedes aegypti mosquitoes, is a significant public health concern in tropical and subtropical regions.
Md. Shohel Hossain, Soharth Hasnat, Soharth Hasnat, Shilpy Akter, Maria Mulla Mim, Anika Tahcin, Majedul Hoque, Durjoy Sutradhar, Mst. Alifa Akter Keya, Namin Rouf Sium, Sophia Hossain, Runa Masuma, Sakhawat Hossen Rakib, Md. Aminul Islam, Tofazzal Islam, Prosun Bhattacharya, M. Nazmul Hoque   +16 more
doaj   +1 more source

Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.

PLoS ONE, 2014
Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant.
Leandra Barcelos Figueiredo, Tetsu Sakamoto, Luiz Felipe Leomil Coelho, Eliseu Soares de Oliveira Rocha, Marcela Menezes Gomes Cota, Gustavo Portela Ferreira, Jaquelline Germano de Oliveira, Erna Geessien Kroon   +7 more
doaj   +1 more source