Results 11 to 20 of about 27,818 (210)

A Dengue Virus Type 2 (DENV-2) NS4B-Interacting Host Factor, SERP1, Reduces DENV-2 Production by Suppressing Viral RNA Replication [PDF]

Viruses, 2019
Host cells infected with dengue virus (DENV) often trigger endoplasmic reticulum (ER) stress, a key process that allows viral reproduction, without killing the host cells until the late stage of the virus life-cycle.
Jia-Ni Tian, Chi-Chen Yang, Chiu-Kai Chuang, Ming-Han Tsai, Ren-Huang Wu, Chiung-Tong Chen, Andrew Yueh   +6 more
doaj   +3 more sources

Multiple introductions and country-wide spread of DENV-2 genotype II (Cosmopolitan) in Brazil. [PDF]

Virus Evol, 2023
Abstract Dengue virus serotype 2, genotype Cosmopolitan (DENV-2-GII), is one of the most widespread DENV strains globally. In the USA, DENV-2 epidemics have been dominated by DENV-2 genotype Asian-American (DENV-2-GIII), and the first cases of DENV-2-GII were only described in 2019, in Peru, and in 2021 in Brazil.
Gräf T, Ferreira CDN, de Lima GB, de Lima RE, Machado LC, Campos TL, Schemberger MO, Faoro H, Paiva MHS, Bezerra MF, Nascimento V, Souza V, Nascimento F, Mejía M, Silva D, de Oliveira YS, Gonçalves L, Ramos TCA, de Castro DB, Arcanjo AR, Dantas HAP, Presibella MM, Fernandes SB, Gregianini TS, Paz E Silva KM, Sacchi CT, Cruz ACR, Duarte Dos Santos CN, Bispo de Filippis AM, Bello G, Wallau GL, Salvato RS, Naveca F.   +32 more
europepmc   +3 more sources

Multiple arboviral infections during a DENV-2 outbreak in Solomon Islands. [PDF]

Trop Med Health, 2020
Abstract Background Solomon Islands, a country made up of tropical islands, has suffered cyclic dengue fever (DF) outbreaks in the past three decades. An outbreak of dengue-like illness (DLI) that occurred in April 2016 prompted this study, which aimed to determine the population’s immunity status and identify the arboviruses circulating in the country.
Darcy AW, Kanda S, Dalipanda T, Joshua C, Shimono T, Lamaningao P, Mishima N, Nishiyama T.   +7 more
europepmc   +5 more sources

Vector Competence for DENV-2 Among Aedes albopictus (Diptera: Culicidae) Populations in China. [PDF]

Front Cell Infect Microbiol, 2021
Aedes albopictus is a vector of over 20 arboviruses that has spread throughout the world, mainly in the second half of the twentieth century. Approximately 50–100 million people are infected with dengue virus (DENV) transmitted by Aedes mosquitoes each year, leading to heavy economic burdens for both governments and individuals, among countless other ...
Wei Y, Wang J, Wei YH, Song Z, Hu K, Chen Y, Zhou G, Zhong D, Zheng X.   +8 more
europepmc   +7 more sources

A lethal DENV-2 wild-type mouse model for mutagenesis investigations. [PDF]

BMC Biol
BACKGROUND: Effective mouse models for testing antiviral medications should be both cost-effective and require minimal labor. Immunodeficient mouse models, such as AG129, are commonly used in dengue virus (DENV) research; however, their high import and maintenance costs make them relatively expensive. Moreover, the absence of IFN-γ signaling limits the
Qin Z, Xie X, Ye H, Wu H, Li Z, Li J, He X, Liang Z, Liu X, Zhu L, Wu Q, Xiao W, Wu K, Wan C, Zhang B, Sun Z, Yu J, Shen C, Yu L, Zhao W.   +19 more
europepmc   +2 more sources

Infecting mosquitoes alters DENV-2 characteristics and enhances hemorrhage-induction potential in Stat1-/- mice. [PDF]

PLoS Negl Trop Dis, 2021
Dengue is one of the most prevalent arthropod-borne viral diseases in humans. There is still no effective vaccine or treatment to date. Previous studies showed that mosquito-derived factors present in saliva or salivary gland extract (SGE) contribute to the pathogenesis of dengue.
Cheang KW, Chen WY, Wu-Hsieh BA, Shiao SH.   +3 more
europepmc   +5 more sources

Role of c-ABL in DENV-2 Infection and Actin Remodeling in Vero Cells. [PDF]

Int J Mol Sci
Dengue is one the most significant mosquito-borne viral diseases globally, with its prevalence extending across tropical and subtropical regions, exerting a considerable financial strain on health systems. Despite decades of research leading to the development of a vaccine implemented in endemic countries, its usage remains restricted to a fraction of ...
Carreño-Flórez GP, Cuartas-López AM, Boudreau RL, Vicente-Manzanares M, Gallego-Gómez JC.   +4 more
europepmc   +3 more sources

Suppression of TGF-β/Smad2 signaling by GW788388 enhances DENV-2 clearance in macrophages. [PDF]

J Med Virol, 2022
AbstractDengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor‐β1 (TGF‐β1) in the patient's serum.
Teixeira GS, Andrade AA, Torres LR, Couto-Lima D, Moreira OC, Abreu R, Waghabi MC, de Souza EM.   +7 more
europepmc   +3 more sources

Eugenol isolated from supercritical fluid extract of Ocimum sanctum: a potent inhibitor of DENV-2. [PDF]

AMB Express, 2023
AbstractDengue is one of the fairly prevalent viral infections at the world level transmitted through mosquitoes (Aedes aegypti and Aedes albopictus). Due to various environmental factors, dengue cases surged rapidly at the global level in recent decades, with 193245 cases in 2021 and an increment of 110473 cases in 2022. There is no antidote available
Kaushik S, Kaushik S, Dar L, Yadav JP.
europepmc   +4 more sources

DENV-2 Outbreak Associated With Cosmopolitan Genotype Emergence in Western Brazilian Amazon. [PDF]

Bioinform Biol Insights
Background: Dengue virus (DENV) causes an important disease and directly affects public health, being the arbovirus that presents the highest number of infections and deaths in the Western Brazilian Amazon. This virus is divided into 4 serotypes that have already circulated in the region.
Ribeiro JR, Roca TP, Cartonilho GDS, Passos-Silva AM, Moreira HM, Teixeira KS, da Silva ALF, Lugtenburg CAB, Dos Santos AO, Villalobos Salcedo JM, do Nascimento VA, de Souza VC, Roque RA, Krieger MA, Naveca FG, Rampazzo RCP, Vieira DS.   +16 more
europepmc   +4 more sources