Results 21 to 30 of about 27,818 (210)

Emergence of a New Strain of DENV-2 in South America: Introduction of the Cosmopolitan Genotype through the Brazilian-Peruvian Border [PDF]

Tropical Medicine and Infectious Disease, 2023
Dengue virus 2 (DENV-2) seriously contributes to dengue-related mortality. It includes five nonsylvatic genotypes, with cosmopolitan being the most widespread with a significant contribution to the total number of DENV-2 cases globally. In South America,
Murilo Tavares Amorim, Leonardo H. Almeida Hernández, Felipe Gomes Naveca, Ivy Tsuya Essashika Prazeres, Ana Lucia Monteiro Wanzeller, Eliana Vieira Pinto da Silva, Livia M. Neves Casseb, Fábio Silva da Silva, Sandro Patroca da Silva, Bruno Tardelli Diniz Nunes, Ana Cecília Ribeiro Cruz   +10 more
doaj   +2 more sources

In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2). [PDF]

Molecules, 2021
Dengue virus (DENV), a member of the family Flaviviridae, is a threat for global health as it infects more than 100 million people yearly. Approved antiviral therapies or vaccines for the treatment or prevention of DENV infections are not available. In the present study, natural compounds were screened for their antiviral activity against DENV by in ...
Panda K, Alagarasu K, Patil P, Agrawal M, More A, Kumar NV, Mainkar PS, Parashar D, Cherian S.   +8 more
europepmc   +5 more sources

[Phosphoproteomic analysis of human umbilical venous endothelial cells with DENV-2 infection]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2023
To analyze the differentially phosphorylated proteins in DENV-2-infected human umbilical venous endothelial cells (HUVECs) and explore the possible pathogenic mechanism of DENV-2 infection.The total proteins were extracted from DENV-2-infected HUVECs and blank control HUVEC using SDT lysis method.
Hu P, Cheng Y, Wang Y, Gou X, Liu H, Zuo L, Wu N.   +6 more
europepmc   +3 more sources

A bivalent form of nanoparticle-based dengue vaccine stimulated responses that potently eliminate both DENV-2 particles and DENV-2-infected cells

Vaccine, 2023
Dengue is the most prevalent mosquito-borne viral disease and continues to be a global public health concern. Although a licensed dengue vaccine is available, its efficacy and safety profile are not satisfactory. Hence, there remains a need for a safe and effective dengue vaccine. We are currently developing a bivalent dengue vaccine candidate.
Mathurin, Seesen, Tuksin, Jearanaiwitayakul, Jitra, Limthongkul, Panuwat, Midoeng, Panya, Sunintaboon, Sukathida, Ubol   +5 more
openaire   +2 more sources

Dengue virus serotype 2 (DENV-2) outbreak, French Polynesia, 2019 [PDF]

Eurosurveillance, 2019
In 1996–97, the last dengue virus serotype 2 (DENV-2) outbreak occurred in French Polynesia. In February 2019, DENV-2 infection was detected in a traveller from New Caledonia. In March, autochthonous DENV-2 infection was diagnosed in two residents. A DENV-2 outbreak was declared on 10 April with 106 cases as at 24 June.
Aubry, Maite, Mapotoeke, Mihiau, Teissier, Anita, Paoaafaite, Tuterarii, Dumas-Chastang, Elsa, Giard, Marine, Cao-Lormeau, Van-Mai   +6 more
openaire   +2 more sources

Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King

Tropical Biomedicine, 2021
The NS2B/NS3 protease is crucial for the pathogenesis of the DENV. Therefore, the inhibition of this protease is considered to be the key strategy for the development of new antiviral drugs. In the present study, malabaricones C (3) and E (4), acylphenols from the fruits of Myristica cinnamomea King, have been respectively identified as moderate (27.33
Sivasothy, Y., Liew, SY, Othman, MA, Wahab, Abdul S.M, Hariono, Maywan, Nawi, Mohd, Wahab, Abdul A, Awang, K   +7 more
openaire   +2 more sources

DENV 2 Infection v1

, 2023
En este protocolo se describen las condiciones para el mantenimiento de las líneas celulares C6/36 HT y BHK-21, además del procedimiento de infección y plaqueo del DENV 2
Edwin Stiven Quiguanás, Delia Piedad Recalde-Reyes   +1 more
openaire   +1 more source

Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes

Virology, 2012
The envelope (E) protein is composed of three domains (ED1, ED2 and ED3) with ED3 targeted by the most potent neutralizing antibodies. DENV-2 strains can be divided into six genotypes. Comparison of ED3 of representative strains of the six genotypes revealed that there are nine variable residues that are specific to a given genotype.
Pitcher, Trevor J., Gromowski, Gregory D., Beasley, David W.C., Barrett, Alan D.T.   +3 more
openaire   +2 more sources

RNA Isolation of Dengue Virus Type 2 with Different Precipitation Solvents : Methanol, Chloroform, and 2-Isopropanol.

Jurnal Kimia Riset, 2018
Dengue virus distributed in tropical and subtropical regions in the world. DENV viruses are transmitted between humans primarily by Aedes aegypti and Aedes albopictus mosquitoes and are endemic in most areas in which the vectors occur.
Yovilianda Maulitiva Untoro, Teguh Hari Sucipto, Harsasi Setyawati, Siti Churrotin, Ilham Harlan Amarullah, Puspa Wardhani, Aryati Aryati, Shuhai Ueda, Soegeng Soegijanto   +8 more
doaj   +1 more source

INHIBITORY ACTIVITY OF COBALT(II)–MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2

Indonesian Journal of Tropical and Infectious Disease, 2017
Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. Antidengue treatments are urgently required to control the emergence of dengue.
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati Setyawati, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Shuhai Ueda, Tomohiro Kotaki, Sri Sumarsih, Puspa Wardhani, Sri Subekti Bendryman, Aryati Aryati, Soegeng Soegijanto, Masanori Kameoka   +12 more
doaj   +1 more source