Results 91 to 100 of about 41,784 (287)

5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16Ink4a expression in lung tissue

, 2017
Zhi-Hui He,1 Yan Chen,2 Ping Chen,2 Sheng-Dong He,2 Hui-Hui Zeng,2 Ji-Ru Ye,2 Da Liu,2 Jun Cao3 1Intensive Care Unit, 2Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, 3Department of Respiratory Medicine ...
He SD, Chen P, He ZH, Cao J, Ye JR, Chen Y, Zeng HH, Liu D   +7 more
core  

Use of a Ureido-Substituted Deoxycytidine Module for DNA Assemblies

, 2016
Ureido-substituted cytosine derivatives are promising for constructing self-assembly structures that can be applied to nanotechnology research. However, conventional cytosine modules achieve assembly in organic solvents.
Shu-ichi Nakano (13222), Naoki Sugimoto (13226), Masayuki Fujii (13225), Hirohito Oka (2334607)   +3 more
core   +1 more source

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

Animal Research and One Health, EarlyView.
The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang, Yu Wang, Dengfeng Bi, Jianguo Zhao, Yanfang Wang   +4 more
wiley   +1 more source

5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias.

, 1984
In this study, the effects of 5-aza-2'-deoxycytidine on differentiation of human leukemic cells in primary suspension culture are reported for the first time.
Spada O. A, Attadia V, Pinto A, Di Fiore P., FUSCO, ALFREDO, Ferrara F   +5 more
core   +3 more sources

Cell cycle regulation of deoxycytidine kinase Evidence for post-transcriptional control [PDF]

, 1993
Deoxycytidine kinase enzyme activity and deoxycitidine kinase mRNA content were determined at different positions of the cell cycle in permanent cell lines.
Hengstschläger, Markus, Markus Hengstschläger, Denk, Claudia, Wawra, Edgar, Edgar Wawra, Claudia Denk   +5 more
core   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy

Journal for ImmunoTherapy of Cancer
Background Cellular immunotherapy using modified T cells offers new avenues for cancer treatment. T-cell receptor (TCR) engineering of CD8 T cells enables these cells to recognize tumor-associated antigens and tumor-specific neoantigens.
Marieke Griffioen, Noel F C C de Miranda, Sumit Kumar, Jessie S Kroonen, Ilona J de Graaf, Alfred C O Vertegaal, Tassilo L A Wachsmann, Anne K Wouters, Dennis F G Remst, Mirjam H M Heemskerk, Jessica P Roelands, Amina F A S Teunisse   +11 more
doaj   +1 more source

Collisionally Activated Dissociation of Protonated 2′-Deoxycytidine, 2′-Deoxyuridine, and their Oxidatively Damaged Derivatives [PDF]

, 2006
We examined the collisionally activated dissociation (CAD) pathways of protonated 2′-deoxycytidine (dC), 5-formyl-2′-deoxycytidine (5-FmdC), 5-hydroxy-2′-deoxycytidine (5-OHdC), 5-hydroxymethyl-2′-deoxycytidine (5-HmdC), and their corresponding stable ...
Huachuan Cao, Yinsheng Wang, Cao, Huachuan, Wang, Yinsheng   +3 more
core   +1 more source

Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study

British Journal of Clinical Pharmacology, EarlyView.
Aim In the GENESECT study, no significant gemcitabine (GEM) metabolism‐related germline genetic polymorphisms (GPs) were identified because approximately 70% of patients received combination therapy with nab‐paclitaxel, which has metabolic pathways different from GEM.
Takashi Yokokawa, Daiki Tsuji, Masahiro Hatori, Kazuyoshi Kawakami, Masahiko Nakao, Takuya Yano, Yuichiro Arakawa, Keisuke Matsuo, Yasukata Ohashi, Masato Ozaka, Naoki Sasahira, Yasuhiko Sakata, Yuki Kogure, Shinya Tamaki, Atsushi Wada, Yusuke Taki, Wataru Suzuki, Kazuo Kobayashi, Hiroshi Ishii, Kunihiko Itoh, Masakazu Yamaguchi, Kenichi Suzuki   +21 more
wiley   +1 more source

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source