Results 101 to 110 of about 41,784 (287)
Gene expression profiling of human myeloid leukemic MV4-11 cells treated with 5-Aza-2’-deoxycytidine
The pyrimidine analog, 5-aza-2’-deoxycytidine (5-aza-dC) is a DNA methyltransferase inhibitor that triggers DNA demethylation leading to the reactivation of epigenetically silenced tumor suppressor genes.
David Mossman (211006) +3 more
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Uncatalyzed Guanosine Phosphorylation under Potentially Prebiotic Conditions
Chemistry – A European Journal, EarlyView.Pyrophosphate acts as phosphorylating agent of guanosine under simple wet‐dry cycles without condensing agent and inorganic catalysts to afford cyclic guanosine monophosphate derivatives useful for oligomerization in prebiotic processes. ABSTRACT The phosphorylation of nucleosides and their subsequent polymerization are key issues in the study of the ...
Martina Proietti +5 more
wiley +1 more source
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Synthesis and study of n4-aminoacid-modified 2'-deoxycytidine nucleotides. [PDF]
, 2020 Nucleoside 5'-triphosphates [(d)NTPs] play an essential role in many biological processes. Natural (d)NTPs act as monomers for polymerase-mediated nucleic acid synthesis both in vivo and in vitro.
Koplūnaitė, Martyna,
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Flavour and Fragrance Journal, EarlyView.This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez +2 more
wiley +1 more source
Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation
eLifeHost-directed therapy (HDT) is an emerging approach to overcome antimicrobial resistance in pathogenic microorganisms. Specifically, HDT targets host-encoded factors required for pathogen replication and survival without interfering with microbial growth
Volker Winstel +3 more
doaj +1 more source
, 2017 The 5,6-dihydroxy-5,6-dihydro-5-methyl-2’-deoxycytidine is an oxidation product formed by hydroxyl radical (•OH). The same product has been obtained by menadione photosensitization of 5-methyl-2’-deoxycytidine (m5dCyd). 18O labeling experiments led us to
C Bienvenu, J Cadet, C Lebrun
core +1 more source
Effect of 5-aza-2’-deoxycytidine in metanephric organ culture.
, 2020 Embryonic day 13 metanephroi from normal dams were subjected to organ culture in the absence (CON) or presence of 5-aza-2’-deoxycytidine (Aza) for 3 days. Ureteric buds were visualized by whole mount staining with anti-pancytokeratin antibody.
Mariko Hida (7340018) +1 more
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari +10 more
wiley +1 more source