Results 101 to 110 of about 39,457 (305)

Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors

, 1988
Deoxycytidine metabolism was investigated in light density human tonsillar lymphocytes using 5-3H-deoxycytidine as extracellular precursor. A significant portion of the deoxycytidine (more than 50% of ethanol soluble pool) was found to incorporate into ...
Spasokukotskaja, T.,, Staub, M.,, Spyrou, Giannis,   +2 more
core  

Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation [PDF]

, 1999
5-Methyl-2′-deoxycytidine (5-Me-dC) is formed by the enzymatic methylation of dC, primarily in CpG sequences in DNA, and is involved in the regulation of gene expression.
Ueno, Yoshihito, Murata-Kamiya, Naoko, Karino, Naoko, Kaji, Hiroshi, Kasai, Hiroshi, Matsuda, Akira, Kamiya, Hiroyuki   +6 more
core   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias.

, 1984
In this study, the effects of 5-aza-2'-deoxycytidine on differentiation of human leukemic cells in primary suspension culture are reported for the first time.
Spada O. A, Attadia V, Pinto A, Di Fiore P., FUSCO, ALFREDO, Ferrara F   +5 more
core   +1 more source

Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy

Journal for ImmunoTherapy of Cancer
Background Cellular immunotherapy using modified T cells offers new avenues for cancer treatment. T-cell receptor (TCR) engineering of CD8 T cells enables these cells to recognize tumor-associated antigens and tumor-specific neoantigens.
Marieke Griffioen, Noel F C C de Miranda, Sumit Kumar, Jessie S Kroonen, Ilona J de Graaf, Alfred C O Vertegaal, Tassilo L A Wachsmann, Anne K Wouters, Dennis F G Remst, Mirjam H M Heemskerk, Jessica P Roelands, Amina F A S Teunisse   +11 more
doaj   +1 more source

Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors

Molecular Therapy: Nucleic Acids, 2016
Direct reprogramming of pancreatic nonendocrine cells into insulin-producing β-cells represents a promising approach for the treatment of insulin-dependent diabetes.
Tomas Koblas, Ivan Leontovyc, Sarka Loukotova, Lucie Kosinova, Frantisek Saudek   +4 more
doaj   +1 more source

Collisionally Activated Dissociation of Protonated 2′-Deoxycytidine, 2′-Deoxyuridine, and their Oxidatively Damaged Derivatives

, 2006
We examined the collisionally activated dissociation (CAD) pathways of protonated 2′-deoxycytidine (dC), 5-formyl-2′-deoxycytidine (5-FmdC), 5-hydroxy-2′-deoxycytidine (5-OHdC), 5-hydroxymethyl-2′-deoxycytidine (5-HmdC), and their corresponding stable ...
Huachuan Cao, Yinsheng Wang, Cao, Huachuan, Wang, Yinsheng   +3 more
core   +1 more source

Tumor‐Mimic Artificial Cell Integrated With In Situ Synthetic Biology for Testing of Antitumor Drug Sensitivity

Exploration, EarlyView.
A biomimetic artificial cell model platform integrating in situ synthetic biology is developed, which can show antitumor drug response to simulated cells derived from cell membranes of different tumor cells. It has excellent performance in indicating the curative effect of drugs at the cellular level and provides a novel approach for enhancing the ...
Chaoyang Guan, Runchi Zhang, Zhihui Zhou, Pei Sun, Yichun Mao, Changqing Mao, Yonggeng Ma, Guifang Chen, Qiuhong Man, Chang Feng   +9 more
wiley   +1 more source

Restoration of DKK1 expression in MM cell lines by 5-aza-2-deoxycytidine treatment.

, 2012
(A) DKK-1 promoter methylation analyzed by bisulfite genomic sequencing of 10 clones, on DNA isolated from 5-aza-2-deoxycytidine treated (5-aza-CdR) and untreated (PBS) MM cell lines UM-1 and OPM-1. Frequency of methylation was calculated by dividing the
Richard W. J. Groen (182567), Kinga A. Kocemba (182559), Marie José Kersten (182580), Steven T. Pals (182598), Harmen van Andel (182572), Marcel Spaargaren (182591), Karène Mahtouk (182586)   +6 more
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source