Results 81 to 90 of about 41,784 (287)
The Role of Different TET Proteins in Cytosine Demethylation Revealed by Mathematical Modeling
EpigenomesIn living cells, some reactions can be conducted by more than one enzyme and sometimes it is difficult to establish which enzyme is responsible. Such is the case with proteins from the TET family, capable of converting 5-methyl-2’-deoxycytidine (5-mdC ...
Karolina Kurasz +4 more
doaj +1 more source
Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency [PDF]
, 2017 Objective: Thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial pyrimidine salvage pathway, is essential for mitochondrial DNA (mtDNA) maintenance.
Garone C. +8 more
core +1 more source
Gender effects on cytidine analogue metabolism and myelodysplastic syndrome treatment outcomes [PDF]
, 2012 In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine ...
Joseph Covey +13 more
core
, 1997 We describe the reaction of formamide with 2'-deoxycytidine to give pyrimidine ring opening by nucleophilic addition on the electrophilic C(6) and C(4) positions.
G. COSTANZO +22 more
core +1 more source
EClinicalMedicineSummary: Background: DNA polymerase gamma (POLG)-related disorders are a group of rare neurodegenerative mitochondrial diseases caused by pathogenic variants in POLG, the gene encoding POLG.
Heather Pekeles +8 more
doaj +1 more source
International Journal of Ophthalmology, 2014 AIM:To investigate the effect of 5-Aza-2’-deoxycytidine (5-Aza-CdR), a DNA methyltransferase (DNMT) inhibitor, on the growth and survival of the Chinese retinoblastoma (RB) cell line HXO-RB44.METHODS:The DNA methylation status of the Ras association ...
Ru Liu +6 more
doaj +1 more source
, 2016 5-Methylcytosine is a minor nucleobase of eukaryotic DNA which plays a central role in the regulation of gene expression. UV-A irradiation of an aerated aqueous solution of 5-methyl-2‘-deoxycytidine in the presence of menadione (MQ) as a type I ...
Carine Bienvenu (2998068) +2 more
core +1 more source
Effect of DNMT inhibitor 5-Aza-2′-deoxycytidine on paw edema induced by incision.
, 2015 5-Aza-2′-deoxycytidine significantly reduced incision-induced hindpaw edema. Values are displayed as the mean ± SEM.
Yuan Sun (15554) +6 more
core +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
PLoS ONE, 2013 Vitamin B12, a co-factor in methyl-group transfer, is important in maintaining DNA (deoxycytidine) methylation.
Eoin P Quinlivan +8 more
doaj +1 more source