Results 81 to 90 of about 39,457 (305)

Photo-sensitized formation of the cis-(5R, 6R) diastereomer of 5,6-dihydroxy-5,6-dihydro-5-methyl-2’-deoxycytidine

, 2017
The 5,6-dihydroxy-5,6-dihydro-5-methyl-2’-deoxycytidine is an oxidation product formed by hydroxyl radical (•OH). The same product has been obtained by menadione photosensitization of 5-methyl-2’-deoxycytidine (m5dCyd). 18O labeling experiments led us to
C Bienvenu, J Cadet, C Lebrun
core   +1 more source

The Role of Different TET Proteins in Cytosine Demethylation Revealed by Mathematical Modeling

Epigenomes
In living cells, some reactions can be conducted by more than one enzyme and sometimes it is difficult to establish which enzyme is responsible. Such is the case with proteins from the TET family, capable of converting 5-methyl-2’-deoxycytidine (5-mdC ...
Karolina Kurasz, Joanna Rzeszowska-Wolny, Ryszard Oliński, Marek Foksiński, Krzysztof Fujarewicz   +4 more
doaj   +1 more source

Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen

Clinical Case Reports, 2017
Key Clinical Message Pyoderma gangrenosum (PG) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat ...
Mostafa F. M. Saleh, Yogen Saunthararajah   +1 more
doaj   +1 more source

Effect of 5-aza-2’-deoxycytidine in metanephric organ culture.

, 2020
Embryonic day 13 metanephroi from normal dams were subjected to organ culture in the absence (CON) or presence of 5-aza-2’-deoxycytidine (Aza) for 3 days. Ureteric buds were visualized by whole mount staining with anti-pancytokeratin antibody.
Mariko Hida (7340018), Midori Awazu (7340015)   +1 more
core   +1 more source

5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16Ink4a expression in lung tissue

, 2017
Zhi-Hui He,1 Yan Chen,2 Ping Chen,2 Sheng-Dong He,2 Hui-Hui Zeng,2 Ji-Ru Ye,2 Da Liu,2 Jun Cao3 1Intensive Care Unit, 2Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, 3Department of Respiratory Medicine ...
He SD, Chen P, He ZH, Cao J, Ye JR, Chen Y, Zeng HH, Liu D   +7 more
core  

Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine [PDF]

, 2001
Oligodeoxynucleotides (ODNs) containing 5-formyl-2′-deoxycytidine (fC) were synthesized by the phosphoramidite method and subsequent oxidation with sodium periodate.
Ueno, Yoshihito, Karino, Naoko, Matsuda, Akira   +2 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Safety and efficacy of deoxycytidine/deoxythymidine combination therapy in POLG-related disorders: 6-month interim results of an open-label, single arm, phase 2 trialResearch in context

EClinicalMedicine
Summary: Background: DNA polymerase gamma (POLG)-related disorders are a group of rare neurodegenerative mitochondrial diseases caused by pathogenic variants in POLG, the gene encoding POLG.
Heather Pekeles, Saoussen Berrahmoune, Christelle Dassi, Anthony C.T. Cheung, Tommy Gagnon, Paula J. Waters, Ralf Eberhard, Daniela Buhas, Kenneth A. Myers   +8 more
doaj   +1 more source

Gender effects on cytidine analogue metabolism and myelodysplastic syndrome treatment outcomes

, 2012
In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine ...
Joseph Covey, Zhenbo Hu, Jaroslaw Maciejewski, Tomas Radivoyevitch, Reda Mahfouz, Yogen Saunthararajah, Quteba Ebrahem, Kory Engelke, Ramon Tiu, Yonghua Ling, Mikkael Sekeres, Ania Jankowska, Kenneth Chan, Pramod Terse   +13 more
core  

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source