Results 61 to 70 of about 39,457 (305)

DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity

Radiation Oncology, 2012
Background Histone modifications and DNA methylation are two major factors in epigenetic phenomenon. Unlike the histone deacetylase inhibitors, which are known to exert radiosensitizing effects, there have only been a few studies thus far concerning the ...
Kim Hak Jae, Kim Jin Ho, Chie Eui Kyu, Da Young Park, Kim In Ah, Kim Il Han   +5 more
doaj   +1 more source

Mechanism of degradation of 2'-deoxycytidine by formamide: Implications for chemical DNA sequencing procedures

, 1997
We describe the reaction of formamide with 2'-deoxycytidine to give pyrimidine ring opening by nucleophilic addition on the electrophilic C(6) and C(4) positions.
G. COSTANZO, Negri, R., SALADINO R., C. CRESTINI, Mincione, E., DI MAURO, E., NEGRI R., DI MAURO E., COSTANZO G., CRESTINI, CLAUDIA, Saladino, R., CRESTINI C, Costanzo, G., Costanzo, G, R. SALADINO, DI MAURO, Ernesto, Saladino, R, DiMauro, E, Crestini, C, E. MINCIONE, Mincione, E, Negri, R, MINCIONE E.   +22 more
core   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

The Role of BMP7 in the Proliferation of Hu Sheep Dermal Papilla Cells Is Influenced by DNA Methylation

Animals
Previous studies have shown that the BMP7 gene is differentially expressed in Hu sheep lamb skin of different pattern types, and its expression level is significantly correlated with hair follicle indices of different pattern types, but the molecular ...
Xiaoyang Lv, Mingliang He, Shanhe Wang, Wenxin Zheng, Hanlin Zhou, Joram M. Mwacharo, Wei Sun   +6 more
doaj   +1 more source

Photosensitized Oxidation of 5-Methyl-2‘-deoxycytidine by 2-Methyl-1,4-naphthoquinone:  Characterization of 5-(Hydroperoxymethyl)-2‘-deoxycytidine and Stable Methyl Group Oxidation Products^§

, 2016
5-Methylcytosine is a minor nucleobase of eukaryotic DNA which plays a central role in the regulation of gene expression. UV-A irradiation of an aerated aqueous solution of 5-methyl-2‘-deoxycytidine in the presence of menadione (MQ) as a type I ...
Carine Bienvenu (2998068), Jean Cadet (14780), J. Richard Wagner (1432498)   +2 more
core   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

Effect of DNMT inhibitor 5-Aza-2′-deoxycytidine on paw edema induced by incision.

, 2015
5-Aza-2′-deoxycytidine significantly reduced incision-induced hindpaw edema. Values are displayed as the mean ± SEM.
Yuan Sun (15554), Wenwu Li (822149), DeYong Liang (37007), Peyman Sahbaie (32783), J. David Clark (159378), Paige Kingery (822150), Xiaoyou Shi (37004)   +6 more
core   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

A general method for purification of deoxycytidine kinase [PDF]

Biochemical Journal, 1978
Deoxycytidine kinase from a variety of animal tissues binds to Cibacron Blue 3G-A coupled to Sepharose CL-6B. The enzyme can be selectively eluted with ATP to yield single-step purifications of 17-89-fold. The affinity adsorbent is re-usable.
A, Baxter, L M, Currie, J P, Durham
openaire   +2 more sources

Use of a Ureido-Substituted Deoxycytidine Module for DNA Assemblies

, 2016
Ureido-substituted cytosine derivatives are promising for constructing self-assembly structures that can be applied to nanotechnology research. However, conventional cytosine modules achieve assembly in organic solvents.
Shu-ichi Nakano (13222), Naoki Sugimoto (13226), Masayuki Fujii (13225), Hirohito Oka (2334607)   +3 more
core   +1 more source