Results 111 to 120 of about 39,457 (305)
Gene expression profiling of human myeloid leukemic MV4-11 cells treated with 5-Aza-2’-deoxycytidine
The pyrimidine analog, 5-aza-2’-deoxycytidine (5-aza-dC) is a DNA methyltransferase inhibitor that triggers DNA demethylation leading to the reactivation of epigenetically silenced tumor suppressor genes.
David Mossman (211006) +3 more
core
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Synthesis and study of n4-aminoacid-modified 2'-deoxycytidine nucleotides.
, 2020 Nucleoside 5'-triphosphates [(d)NTPs] play an essential role in many biological processes. Natural (d)NTPs act as monomers for polymerase-mediated nucleic acid synthesis both in vivo and in vitro.
Koplūnaitė, Martyna,
core
A Nonlinear Quantitative Model for Measuring Concentration Ratios From Raman Intensities
Journal of Raman Spectroscopy, EarlyView.Estimating concentration from Raman intensity ratios is complicated by cross‐contributions from overlapping peaks, causing measured ratios to deviate from the linear behavior assumed in conventional quantitative models. This nonlinear method fully accounts for cross‐contributions, allowing estimation of concentration over several orders of magnitude ...
Joseph Razzell Hollis
wiley +1 more source
Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation
eLifeHost-directed therapy (HDT) is an emerging approach to overcome antimicrobial resistance in pathogenic microorganisms. Specifically, HDT targets host-encoded factors required for pathogen replication and survival without interfering with microbial growth
Volker Winstel +3 more
doaj +1 more source
, 2018 Differential H3K4me3 enrichment profiling after KDM5i, DAC, or ...
Tommy K. Cheung (8612133) +8 more
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre +5 more
wiley +1 more source
Rapid Communications in Mass Spectrometry, EarlyView.ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont +9 more
wiley +1 more source
The Inhibition of Human Deoxycytidine Kinase Mutants by Deoxycytidine Triphosphate
, 2014 Deoxycytidine kinase (dCK) is responsible for catalyzing the phosphorylation of nucleosides to monophosphate forms within the nucleoside salvage pathway by using nucleotide triphosphates ATP or UTP as a phosphoryl donor.
Reese, Loriann Noelle
core
Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping
The Chemical Record, EarlyView.Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato +3 more
wiley +1 more source