Results 111 to 120 of about 55,224 (274)

Loci specific epigenetic drug sensitivity. [PDF]

, 2020
Therapeutic targeting of epigenetic modulators offers a novel approach to the treatment of multiple diseases. The cellular consequences of chemical compounds that target epigenetic regulators (epi-drugs) are complex.
Pilko, Anna, Wollman, Roy, Zhang, Thanutra   +2 more
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy

Journal for ImmunoTherapy of Cancer
Background Cellular immunotherapy using modified T cells offers new avenues for cancer treatment. T-cell receptor (TCR) engineering of CD8 T cells enables these cells to recognize tumor-associated antigens and tumor-specific neoantigens.
Marieke Griffioen, Noel F C C de Miranda, Sumit Kumar, Jessie S Kroonen, Ilona J de Graaf, Alfred C O Vertegaal, Tassilo L A Wachsmann, Anne K Wouters, Dennis F G Remst, Mirjam H M Heemskerk, Jessica P Roelands, Amina F A S Teunisse   +11 more
doaj   +1 more source

The complex story of intergenomic recombination in ABB allotriploid bananas. [W099] [PDF]

, 2020
Bananas (Musa spp.) are a major staple food for hundreds of millions of people in developing countries. The cultivated varieties are seedless and parthenocarpic clones of which the ancestral origin remains to be clarified.
Breton, Catherine, Carpentier, Sébastien Christian, Cenci, Alberto, Martin, Guillaume, Rouard, Mathieu, Roux, Nicolas, Sardos, Julie, Swennen, Rony   +7 more
core  

Intratumoral Enterobacter hormaechei drives gemcitabine resistance in pancreatic cancer via cddL‐mediated drug inactivation

iMeta, EarlyView.
Gemcitabine resistance poses a critical barrier to improving survival in pancreatic cancer, yet the microbial drivers remain elusive. By integrating 16S rRNA amplicon sequencing with large‐scale culturomics across 114 clinical samples, we identified Enterobacter hormaechei as a key intratumoral pathogen. We demonstrate that E.
Jun‐Feng Peng, Meixia Li, Ting Niu, Judong Li, Wei Niu, Minghui Zheng, Quanjiang Ji, Chuan Li, Chenghao Shao, Kan Ding   +9 more
wiley   +1 more source

Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors

Molecular Therapy: Nucleic Acids, 2016
Direct reprogramming of pancreatic nonendocrine cells into insulin-producing β-cells represents a promising approach for the treatment of insulin-dependent diabetes.
Tomas Koblas, Ivan Leontovyc, Sarka Loukotova, Lucie Kosinova, Frantisek Saudek   +4 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Plasma Deoxycytidine: Increased Levels after X-Irradiation

Experimental Biology and Medicine, 1968
SummaryThe demonstration of dose-dependent increase in plasma deoxycytidine (CdR) in rats after their exposure to relatively low doses of X-rays, suggests that the quantitative determination of this compound as early as 4-hours postirradiation might be of value as a biologic dosimeter or indicator of radiation injury at sublethal doses.
C D, Guir, K F, Swingle, L J, Cole
openaire   +2 more sources

A Nonlinear Quantitative Model for Measuring Concentration Ratios From Raman Intensities

Journal of Raman Spectroscopy, EarlyView.
Estimating concentration from Raman intensity ratios is complicated by cross‐contributions from overlapping peaks, causing measured ratios to deviate from the linear behavior assumed in conventional quantitative models. This nonlinear method fully accounts for cross‐contributions, allowing estimation of concentration over several orders of magnitude ...
Joseph Razzell Hollis
wiley   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source