Results 131 to 140 of about 34,947 (246)

Quantifying Epigenetic Changes Induced by Chemical Exposure Using the epi-TK Assay. [PDF]

Bio Protoc
Kuroki S, Yamada H, Odagiri M, Sugiyama KI, Yasui M, Sassa A.   +5 more
europepmc   +1 more source

Synthesis of DNA Building Blocks With Aminonaphthalimides and Cyanovinylenes as Uncharged Fluorophores: Fluorescent Readout From Turn‐On to Red‐Shift

European Journal of Organic Chemistry, Volume 29, Issue 29, 7 August 2026.
DNA architectures with aminonaphthalimides and cyanovinylenes as base surrogates form interstrand and intrastrand dimers showed that can be used as nucleic acid‐sensitive probes by their fluorescence turn‐on and red‐shift as readouts. The fluorescence turn‐on was tested by probing N6‐methyl‐2’‐deoxyadenosine (m6A) in DNA.
Jan Kunzmann, Anna‐Lena Ruopp, Hans‐Achim Wagenknecht   +2 more
wiley   +1 more source

Response of <i>Escherichia coli</i> chemotaxis pathway to pyrimidine deoxyribonucleosides. [PDF]

Microbiol Spectr
Shah M, Xu W, Sourjik V.
europepmc   +1 more source

Downregulation of Cyclin Kinase Inhibitors p16INK4a and p27 in Conjunctival Melanomas. [PDF]

Invest Ophthalmol Vis Sci
Sarrasin E, Lalys E, Nardou K, Celik E, Quinodoz M, Schalenbourg A, Riggi N, Rivolta C, Berger A, Moulin A.   +9 more
europepmc   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Mechanistic insight into complement C3 regulation during chronic HBV infection: effect on viral persistence and host immune response. [PDF]

J Biomed Sci
Baidya A, Dey D, Mallik S, Halder S, Khatun N, Jha R, Nandi S, Chakraborty BC, Dutta A, Banerjee S, Chowdhury A, Ahammed SKM, Datta S.   +12 more
europepmc   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Development of a Real-Time Fluorescence-Based Deamination Assay and Identification of Inhibitors of Human Cytidine Deaminase. [PDF]

ACS Chem Biol
Moorthy R, Grillo MJ, Baur JW, Schmidt SA, Passow KT, Demir Ö, Tang J, Olson ME, Amaro RE, Harki DA.   +9 more
europepmc   +1 more source

A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2180-2191, August 2026.
Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm, Martin Pfeiffer, Johannes Zöhrer, Bernd Nidetzky   +3 more
wiley   +1 more source

DNA hypermethylation of nonspecific cytotoxic cell receptor protein 1 and poor prognosis of pancreatic cancer. [PDF]

Oncol Lett
Nakamura M, Hagiwara T, Yamada K, Igari T, Fukumura Y, Saiura A, Takemura N, Kokudo N, Kawamura YI.   +8 more
europepmc   +1 more source