Results 121 to 130 of about 34,947 (246)

Increasing TET Expression and 5‐Hydroxymethylcytosine Formation by a Carbocyclic 5‐Aza‐2′‐deoxy‐cytidine Antimetabolite

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Maike Däther, Elsa Peev, Annika Fröhlich, Binje Vick, Sogol Fatourechi, Gilles Gasparoni, Matthias Heiss, Corinna C. Pleintinger, Emmanuel Asu Bisong, Hans Hurmiz, Davide Guglielminotti, Yasmin V. Gärtner, Tina Aumer, Karsten Spiekermann, Jörn Walter, Irmela Jeremias, Franziska R. Traube, Thomas Carell   +17 more
wiley   +2 more sources

Simultaneous quantification of cytidine, methylcytidine, and hydroxymethylcytidine by isotope-dilution LC-MS/MS with application to mouse liver samples. [PDF]

J Chromatogr A
Mishra P, Ma J, Xie H, Li F, Tsai RYL, Liang D.   +5 more
europepmc   +1 more source

Technologies for engineering repetitive DNA

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley   +1 more source

Epigenetic drug control of Clec4g/LSECtin expression reduces fibrosis burden in cirrhosis. [PDF]

Hepatol Commun
Ángel-Gomis E, Gómez-Hurtado I, Fernández-Barrena MG, Juanola O, Martínez-López S, Boix P, Ávila MA, Caparrós E, Francés R.   +8 more
europepmc   +1 more source

High‐density mutation tracks are associated with proton‐beam irradiation patterns in Sorghum bicolor

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Induced mutagenesis is a cornerstone of crop functional genomics, yet the extent to which distinct radiation sources reshape the spatial distribution of mutations remains difficult to evaluate in reduced‐representation datasets. Here, we analyze a published genotyping‐by‐sequencing (GBS) panel (192,040 loci) to compare proton‐beam and gamma ...
Ezekiel Ahn, Insuck Baek, Seunghyun Lim, Louis K. Prom, Moon S. Kim, Lyndel W. Meinhardt, Clint Magill   +6 more
wiley   +1 more source

Effect of Renal Impairment on the Pharmacokinetics and Safety of Doxecitine and Doxribtimine: A Single-Dose Phase 1 Study. [PDF]

Clin Pharmacol Drug Dev
Mittur A, VanMeter SA.
europepmc   +1 more source

Structural and Functional Insights Into (S)‐5′‐C‐Guanidinopropyl Uridine‐Modified Oligonucleotides With 2′‐O‐Methyl and 2′‐Fluoro Substitutions for RNAi Therapeutics

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Novel (S)‐5′‐guanidinopropyl uridine analogs bearing 2′‐O‐methyl or 2′‐fluoro substitutions enhance nuclease resistance and mismatch discrimination while preserving A‐form RNA structure and potent RNAi activity. These modifications provide a promising strategy for improving the stability, specificity, and therapeutic potential of siRNA‐based medicines.
Sugahara Masaki, Elsayed M. Mahmoud, Shuichi Sakamoto, Yoshihito Ueno   +3 more
wiley   +1 more source

Cladribine Preserves Normal Central Nervous System Cellular Activity and Promotes Neuroprotection to Oxidative Stress Damage. [PDF]

Int J Mol Sci
Eixarch H, Calvo-Barreiro L, Fissolo N, Boschert U, Hervera A, Comabella M, Montalban X, Espejo C.   +7 more
europepmc   +1 more source

Human Deoxycytidine Kinase

Journal of Biological Chemistry, 1989
S H Huang, J M Tomich, H Wu, A Jong, J Holcenberg   +4 more
openaire   +1 more source

Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA

ChemPhysChem, Volume 27, Issue 15, 14 August 2026.
One‐electron oxidation of purine and pyrimidine bases of isolated and cellular DNA generates related reactive base radical cations that are converted into final decomposition products through deprotonation and hydration. In the case of guanine, the most susceptible nucleobase to one‐electron oxidants, 8‐hydroxy‐7,8‐dihydroguanyl radical, thus formed by
Jean Cadet, Dimitar Angelov, Paolo DI Mascio, J. Richard Wagner   +3 more
wiley   +1 more source