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5-Azacytidine and decitabine induce C > G transversions in both murine and human cells. [PDF]
LeukemiaBertoli R +7 more
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Exposing the DNA methylation-responsive compartment of the leukaemic genome in T-ALL cell lines support its potential as a novel therapeutic target in T-ALL. [PDF]
Clin EpigeneticsBensberg M +5 more
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Effects of 5-Methyl-2'-Deoxycytidine in G-Quadruplex Forming Aptamers d(G<sub>3</sub>C)<sub>4</sub> and d[GCG<sub>2</sub>(CG<sub>3</sub>)<sub>3</sub>C]: Investigating the Key Role of the Loops. [PDF]
BiomoleculesEsposito V +6 more
europepmc +1 more source
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A new deoxycytidine analog, 5-hydroxy-2′-deoxycytidine
Biochemical Medicine, 1974Abstract 5-Hydroxy-2′-deoxycytidine was synthesized as a new compound. It inhibits growth of E. coli only after deamination to 5-hydroxy-2′-deoxyuridine. 5-Hydroxy-2′-deoxycytidine is a more effective inhibitor than 5-hydroxy-2′-deoxyuridine, presumably because maintenance of an inhibitory level of the latter occurs over a longer period of time ...
K K, Leung, D W, Visser
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Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts
European Journal of Cancer, 1993Deoxycytidine kinase (dCK) and deaminase (dCDA) are both key enzymes in the activation and inactivation, respectively, of several deoxycytidine antimetabolites. We determined the total dCK and dCDA activities using standard assays, in 28 human solid tumours grown as xenografts in nude mice, and four corresponding cell lines.
V W, Ruiz van Haperen +6 more
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1998
The clinical importance of the dCTP salvage pathway is given by the fact that deoxycytidine (dCyd) analogs like cytosine arabinoside (ara-C) are activated via the salvage pathway. The non-toxic prodrug ara-C gains its cytotoxic potential by phosphorylation to the 5′-triphosphate ara-CTP. Not only cellular accumulation, but also retention of ara-CTP are
V, Heinemann +3 more
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The clinical importance of the dCTP salvage pathway is given by the fact that deoxycytidine (dCyd) analogs like cytosine arabinoside (ara-C) are activated via the salvage pathway. The non-toxic prodrug ara-C gains its cytotoxic potential by phosphorylation to the 5′-triphosphate ara-CTP. Not only cellular accumulation, but also retention of ara-CTP are
V, Heinemann +3 more
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Science, 1969
The activity of deoxycytidine aminohydrolase in the liver of various species including man was investigated. An enormously high activity was found in human liver. This fact explains the extraordinarily low level of deoxycytidine in human urine in comparison with that of other tested species.
B, Zícha, L, Buric
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The activity of deoxycytidine aminohydrolase in the liver of various species including man was investigated. An enormously high activity was found in human liver. This fact explains the extraordinarily low level of deoxycytidine in human urine in comparison with that of other tested species.
B, Zícha, L, Buric
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Deoxycytidine Transport and Metabolism in Choroid Plexus
Journal of Neurochemistry, 1983Abstract: In vitro, the transport into and release of [3H]deoxycytidine from the isolated choroid plexus, the anatomical locus of the blood‐cerebrospinal fluid barrier, were studied separately. By use of the ability of nitrobenzylthioinosine (NBTI) to inhibit deoxycytidine efflux from choroid plexus, the transport of 1 μM [3H]deoxycytidine into ...
R Spector
exaly +3 more sources
Biochemical Pharmacology, 2003
Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175], improving the efficacy of the cytostatic therapy.
Gergely, Keszler +5 more
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Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175], improving the efficacy of the cytostatic therapy.
Gergely, Keszler +5 more
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Cancer Letters, 1983
Exposure of cultured L1210 cells to [2-14C]deoxycytidine and analysis or radioactivity incorporated into DNA-pyrimidines revealed that 2.7--5.5-fold more radioactivity is incorporated into DNA-thymine than into cytosine bases. Thus the pathway involving deamination of deoxycytidylate to deoxyuridylate and methylation to thymidylate is highly favored ...
Karle, J M, Hoerauf, R M, Cysyk, R L
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Exposure of cultured L1210 cells to [2-14C]deoxycytidine and analysis or radioactivity incorporated into DNA-pyrimidines revealed that 2.7--5.5-fold more radioactivity is incorporated into DNA-thymine than into cytosine bases. Thus the pathway involving deamination of deoxycytidylate to deoxyuridylate and methylation to thymidylate is highly favored ...
Karle, J M, Hoerauf, R M, Cysyk, R L
openaire +2 more sources