Results 231 to 240 of about 39,457 (305)

Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins

The FEBS Journal, Volume 293, Issue 11, Page 3135-3139, June 2026.
Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et al. could advance the engineering of pentatricopeptide repeat proteins, and how in return pentatricopeptide repeat ...
Farley M. Kwok van der Giezen, Ian Small
wiley   +1 more source

Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters. [PDF]

Nanoscale Adv
Yadavalli HC, Nagda R, Kang J, Cho M, Lou C, Yang SW, Thulstrup PW, Bjerrum MJ, Shah P.   +8 more
europepmc   +1 more source

Comparative evaluation of noncanonical amino acids as site‐specific NMR probes for the complex of E. coli SSB with single‐stranded DNA without isotope labelling

The FEBS Journal, Volume 293, Issue 12, Page 3601-3620, June 2026.
Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil, Haocheng Qianzhu, Elwy H. Abdelkader, Adarshi P. Welegedara, Josemon George, Christoph Nitsche, Thomas Huber, Gottfried Otting   +7 more
wiley   +1 more source

Incorporation and Repair of Epigenetic Intermediates as Potential Chemotherapy Agents. [PDF]

Molecules
Herring JL, Sowers ML, Conrad JW, Hackfeld LC, Chang-Gu B, Dilawari R, Sowers LC.   +6 more
europepmc   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

A phase 1 study of orally administered 5-fluoro-2'-deoxycytidine with tetrahydrouridine in patients with refractory solid tumors. [PDF]

Cancer Chemother Pharmacol
Chen AP, Kummar S, Rubinstein L, Zlott J, Coyne GO, Chung V, Newman EM, Lenz HJ, Kelly K, Villaruz LC, Konaté MM, Ferry-Galow KV, Wang L, Kinders RJ, Parchment RE, Covey JM, Holleran JL, Piekarz RL, Miller SB, Juwara L, Beumer JH, Doroshow JH.   +21 more
europepmc   +1 more source

Single‐Cell RNA‐Seq Combined With Bulk RNA‐Seq Revealed the Involvement of Pancreatic Cancer Tissue‐Resident Macrophages in Tumour Progression and the Immunotherapy Response

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Pancreatic cancer remains a highly lethal malignancy with limited therapeutic efficacy and untapped immunotherapeutic potential, largely constrained by immune cell heterogeneity in the tumour microenvironment. Tumour‐associated macrophages (TAMs), especially tissue‐resident macrophages (TRMs), exert complex regulatory roles in tumour ...
Bin Wu, Chundong Hu, Fengchun Lu
wiley   +1 more source

From molecular networks to translational intervention: current progress in the mechanisms of gemcitabine resistance in bladder cancer. [PDF]

Front Immunol
Jin M, Cai Z, Bu M, Liu J, Zhang X.
europepmc   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source