Results 211 to 220 of about 39,457 (305)

Cancer‐Associated Fibroblasts: Central Players in the Plastic Pancreatic Cancer Microenvironment and Therapeutic Targeting

Organ Medicine, Volume 3, Issue 2, Page 76-86, June 2026.
Cancer‐associated fibroblasts (CAFs) are key regulators of the pancreatic tumor microenvironment. Through metabolic reprogramming, CAFs support tumor growth by providing nutrients and remodeling extracellular matrix. CAF heterogeneity, including myCAF, iCAF, and apCAF subsets, contributes to immune modulation and therapeutic resistance.
Ziyi Qin, Jinyang Ma, Rui Ju, Lei Guo
wiley   +1 more source

Effective Reduction in Nuclear DNA Contamination Allows Sensitive Mitochondrial DNA Methylation Determination by LC-MS/MS. [PDF]

Int J Mol Sci
Liang L, González Molina LA, Jellema PG, van Faassen M, Otten LTA, Mennega KP, Hof IH, Dijck-Brouwer DAJ, Dolga AM, Rots MG, Niezen-Koning KE.   +10 more
europepmc   +1 more source

Genome Editing in Root and Tuber Crop Development in Sub‐Saharan Africa

Plant-Environment Interactions, Volume 7, Issue 3, June 2026.
ABSTRACT Precision genome editing, particularly using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9), is advancing crop improvement by enabling targeted and efficient genetic modifications. Root and tuber crops such as potato, cassava, sweet potato, and yam are vital for global food and nutritional
Himanshu Saini, Rohit Kumar, Manjeet, Srinu Banothu, Suram Likhita Reddy, Rajesh Gudihalli Munivenkatappa, Sri Sai Siddartha Naik, Roop Kumar, Rahul Pradhan   +8 more
wiley   +1 more source

KPC-2 Orchestrates Systemic Metabolic Rewiring to Facilitate Antibiotic Adaptation in <i>Klebsiella pneumoniae</i>. [PDF]

Microorganisms
Xie P, Sun J, Wu X, Liu C, Li L, Wu T, Luo Y, Zhou C, Wang F, Hu Y, Sun L, Wang C.   +11 more
europepmc   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights. [PDF]

ACS Infect Dis
Král' M, Das A, Kotačka T, Blahošová A, Liščáková V, Hodek J, Konvalinka J, Demo G, Kožíšek M.   +8 more
europepmc   +1 more source

Tautomerism‐Governed Two‐Proton‐Coupled Electron Transfer in the Oxidation of a Molnupiravir by Electrogenerated Superoxide Radical Anion in N,N‐Dimethylformamide

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
Tautomerization‐assisted oxidation of molnupiravir by superoxide (O2•−) in aprotic DMF. The thermodynamically favored oxime tautomer of the N4‐hydroxycytosine moiety forms a prereactive complex (PRC) with O2•− through hydrogen‐bonding interactions.
Tatsushi Nakayama, Kaisei Hara
wiley   +1 more source

Solution-Phase Synthesis of Boranophosphate and Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides via the H-Boranophosphonate Method. [PDF]

J Org Chem
Takahashi Y, Kato I, Sato K, Wada T.
europepmc   +1 more source

Dynamic Switchable and Transient DNA Condensates Driven by Aptamer‐Ligand or Ion‐Nucleobase Bridged Complexes

Small, Volume 22, Issue 31, 2 June 2026.
Switchable or transient formation and dissociation of the phase‐separated DNA microdroplets generated by metal ions or aptamer‐ligand complexes crosslinking Y‐shaped DNA frameworks and dynamically separated by counter ligands eliminating the bridging metal ions or biocatalysts degrading the aptamer‐ligand complexes, are introduced.
Yichen Han, Yang Sung Sohn, Rachel Nechushtai, Fan Xia, Fujian Huang, Yunlong Qin, Itamar Willner   +6 more
wiley   +1 more source

ZNF844 Suppresses Invasion and Metastasis in Nasopharyngeal Carcinoma by Inhibiting the PI3K-AKT Signaling Pathway. [PDF]

Cancer Sci
Xu J, Chen C, Zhang B, Liao S, Mo Y, Zhang R, Kong X, Jiang W.   +7 more
europepmc   +1 more source