Results 221 to 230 of about 55,224 (274)

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies. [PDF]

Mol Oncol
Pavlová Š, Svozilová H, Krzyžánková M, Sonnek R, Volakhava A, Smirnova A, Grigoreva T, Jašková Z, Synáčková H, Wahl D, Bilčíková M, Červinek L, Pospíšilová Š, Mamedov I, Plevová K.   +14 more
europepmc   +1 more source

Longitudinal characterization of mature beef bull seminal fluid and blood serum metabolome during a 65-day breeding season. [PDF]

Transl Anim Sci
Williams JD, Crouse MS, La Frano MR, Campos-Chillòn LF, Cunningham-Hollinger HC, Field CE, McFarlane ZD.   +6 more
europepmc   +1 more source

DNA hairpin base-flipping dynamics drives APOBEC3A recognition and selectivity.

Phys Chem Chem Phys
Hix MA, Sahankumari AGP, Bhagwat AS, Walker AR.   +3 more
europepmc   +1 more source

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A new deoxycytidine analog, 5-hydroxy-2′-deoxycytidine

Biochemical Medicine, 1974
Abstract 5-Hydroxy-2′-deoxycytidine was synthesized as a new compound. It inhibits growth of E. coli only after deamination to 5-hydroxy-2′-deoxyuridine. 5-Hydroxy-2′-deoxycytidine is a more effective inhibitor than 5-hydroxy-2′-deoxyuridine, presumably because maintenance of an inhibitory level of the latter occurs over a longer period of time ...
K K, Leung, D W, Visser
openaire   +2 more sources

Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts

European Journal of Cancer, 1993
Deoxycytidine kinase (dCK) and deaminase (dCDA) are both key enzymes in the activation and inactivation, respectively, of several deoxycytidine antimetabolites. We determined the total dCK and dCDA activities using standard assays, in 28 human solid tumours grown as xenografts in nude mice, and four corresponding cell lines.
V W, Ruiz van Haperen, G, Veerman, B J, Braakhuis, J B, Vermorken, E, Boven, A, Leyva, G J, Peters   +6 more
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Deoxycytidine and Radiation Response: Exceedingly High Deoxycytidine Aminohydrolase Activity in Human Liver

Science, 1969
The activity of deoxycytidine aminohydrolase in the liver of various species including man was investigated. An enormously high activity was found in human liver. This fact explains the extraordinarily low level of deoxycytidine in human urine in comparison with that of other tested species.
B, Zícha, L, Buric
exaly   +3 more sources

Regulation of Deoxycytidine Kinase by Deoxycytidine and Deoxycytidine 5′ Triphosphate in Whole Leukemia and Tumor Cells

1998
The clinical importance of the dCTP salvage pathway is given by the fact that deoxycytidine (dCyd) analogs like cytosine arabinoside (ara-C) are activated via the salvage pathway. The non-toxic prodrug ara-C gains its cytotoxic potential by phosphorylation to the 5′-triphosphate ara-CTP. Not only cellular accumulation, but also retention of ara-CTP are
V, Heinemann, L, Schulz, R D, Issels, W, Wilmanns   +3 more
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2'-Deoxycytidine-N3-cyanoborane

Acta Crystallographica Section C Crystal Structure Communications, 1996
The structure of the P2 1 2 1 2 1 form of 2'-deoxycytidineN3-cyanoborane, C 10 H 15 BN 4 O 4 , has been determined. The sugar is in the 2 E puckering mode and the C5'-05' bond has a tg conformation while the relative orientation of the sugar and the base remains anti.
Q. Gao, A. Sood, B. Ramsay Shaw, L. D. Williams   +3 more
openaire   +1 more source

Electron Attachment to Microhydrated Deoxycytidine Monophosphate

The Journal of Physical Chemistry B, 2018
DNA constituents are effectively decomposed via dissociative electron attachment (DEA). However, the DEA contribution to radiation damage in living tissues is a subject of ongoing discussion. We address an essential question, how aqueous environment influences the DEA to DNA.
Jaroslav Kočišek, Barbora Sedmidubská, Suvasthika Indrajith, Michal Fárník, Juraj Fedor   +4 more
openaire   +3 more sources

Regulation of human deoxycytidine kinase expression

Advances in Enzyme Regulation, 1993
The human deoxycytidine kinase gene is a single copy gene and is comprised of seven exons that are spread over more than 34 kb of the genome. The 5'-flanking region is highly G/C rich and does not contain CAAT or TATA boxes. This region, when cloned into a recorder gene construct containing the chloramphenicol acetyltransferase gene, is capable of ...
B S, Mitchell, J J, Song, E E, Johnson, E, Chen, J S, Dayton   +4 more
openaire   +2 more sources