Results 1 to 10 of about 1,692 (111)

Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage. [PDF]

J Am Chem Soc, 2023
Single-strand breaks (SSBs) induced via electron attachment were previously observed in dry DNA under ultrahigh vacuum (UHV), while hydrated electrons were found not able to induce this DNA damage in an aqueous solution.
Chomicz-Mańka L, Czaja A, Falkiewicz K, Zdrowowicz M, Biernacki K, Demkowicz S, Izadi F, Arthur-Baidoo E, Denifl S, Zhu Z, Tufekci BA, Harris R, Bowen KH, Rak J.   +13 more
europepmc   +3 more sources

Functionalized electrodes embedded in nanopores: read-out enhancement? [PDF]

Chem Asian J, 2023
Nanogaps functionalized with tiny diamonds can enhance the read‐out of nanopores and detect mutations. Abstract In this review, functionalized nanogaps embedded in nanopores are discussed in view of their high biosensitivity in detecting biomolecules, their length, type, and sequence.
Fyta M.
europepmc   +2 more sources

Unlocking the secrets of ABEs: the molecular mechanism behind their specificity. [PDF]

Biochem Soc Trans, 2023
CRISPR-Cas, the bacterial immune systems, have transformed the field of genome editing by providing efficient, easily programmable, and accessible tools for targeted genome editing.
Chen X, McAndrew MJ, Lapinaite A.
europepmc   +3 more sources

Reactivity of the 2-Methylfuran Phase I Metabolite 3-Acetylacrolein Toward DNA. [PDF]

J Agric Food Chem
2-Methylfuran (2-MF) is a well-known industrial chemical and also formed via thermal treatment of food. One main source of 2-MF in the human diet is coffee.
Schäfer V, Stegmüller S, Becker H, Richling E.   +3 more
europepmc   +3 more sources

Study of the method of spinal cord neuron culture in Sprague–Dawley rats

Ibrain, Volume 9, Issue 3, Page 270-280, Fall 2023., 2023
In this study, the separation and purification methods of spinal cord neuron (SPN) culture, that is, the cytarabine (Ara‐C) inhibition method, the differential velocity adherent method, and natural growth medium for neurons, were compared. The neuron‐specific medium can be grown naturally and cultivated to obtain SPNs of higher purity.
Yi‐Fei Sun, Quan‐Yuan Chang, Narima Eerqing, Chang‐Yan Hu   +3 more
wiley   +1 more source

APOBEC3G protects the genome of human cultured cells and mice from radiation‐induced damage

The FEBS Journal, Volume 290, Issue 7, Page 1822-1839, April 2023., 2023
A3G protects mice from IR‐induced damage and promotes accurate DNA double‐strand breaks repair in cultured cells. Transgenic mice expressing A3G successfully survived lethal irradiation, whereas wild‐type controls quickly succumbed to radiation syndrome.
Yelena Britan‐Rosich, Jing Ma, Eran Kotler, Faizan Hassan, Alexander Botvinnik, Yoav Smith, Ofra Moshel, Abed Nasereddin, Gunjan Sharma, Eli Pikarsky, Susan Ross, Moshe Kotler   +11 more
wiley   +1 more source

A compendium of single extracellular vesicle flow cytometry

Journal of Extracellular Vesicles, Volume 12, Issue 2, February 2023., 2023
Abstract Flow cytometry (FCM) offers a multiparametric technology capable of characterizing single extracellular vesicles (EVs). However, most flow cytometers are designed to detect cells, which are larger than EVs. Whereas cells exceed the background noise, signals originating from EVs partly overlap with the background noise, thereby making EVs more ...
Joshua A. Welsh, Ger J. A. Arkesteijn, Michel Bremer, Michael Cimorelli, Françoise Dignat‐George, Bernd Giebel, André Görgens, An Hendrix, Martine Kuiper, Romaric Lacroix, Joanne Lannigan, Ton G. van Leeuwen, Estefanía Lozano‐Andrés, Shoaib Rao, Stéphane Robert, Leonie de Rond, Vera A. Tang, Tobias Tertel, Xiaomei Yan, Marca H. M. Wauben, John P. Nolan, Jennifer C. Jones, Rienk Nieuwland, Edwin van der Pol   +23 more
wiley   +1 more source

Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 [PDF]

, 2020
Cyanobacteria are key organisms in the global ecosystem, useful models for studying metabolic and physiological processes conserved in photosynthetic organisms, and potential renewable platforms for production of chemicals.
Lea-Smith, David, McCormick, Alistair J., Mills, Lauren   +2 more
core   +3 more sources

Z‐nucleic acids: Uncovering the functions from past to present

European Journal of Immunology, Volume 52, Issue 11, Page 1700-1711, November 2022., 2022
This article summarizes the research on Z‐nucleic acid historically and highlights the milestones in this field, including the discovery, characterization of the Z‐nucleic acids and their biological functions mediated by interacting with Z‐nucleic acid binding proteins such as ZBP1, ADAR1, and so on.
Qiannan Tang
wiley   +1 more source

Spectroscopic and in vitro Investigations of Fe2+/α‐Ketoglutarate‐Dependent Enzymes Involved in Nucleic Acid Repair and Modification

ChemBioChem, Volume 23, Issue 11, June 3, 2022., 2022
A bioinorganic perspective on the AlkB as well as the TET enzyme families, Fe2+/α‐ketoglutarate‐dependent dioxygenases involved in nucleic acid repair and processing, and epigenetic gene regulation is presented in this review. Important spectroscopic techniques which can be useful for in vitro examination of the structure and formation of those ...
David Schmidl, Niko S. W. Lindlar né Jonasson, Annika Menke, Sabine Schneider, Lena J. Daumann   +4 more
wiley   +1 more source